公开(公告)号：US20230250424A1

公开(公告)日：2023-08-10

申请号：US16761151

申请日：2018-10-19

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Sang Hoon JUNG ,  Young-Joo KIM ,  Dae-geun SONG ,  Young Nyun PARK ,  Jeong Eun YOO ,  Hyung Jin RHEE ,  Youngsic JEON

IPC: C12N15/113 ,  A61P35/00 ,  A61P1/16

CPC classification number: C12N15/113 ,  A61P1/16 ,  A61P35/00 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/127 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2310/3181

Abstract: In the present specification, on the basis of the correlation between prospero homeobox protein 1 (PROX1) and telomerase reverse transcriptase (TERT), a composition for regulating expression of TERT, a method for screening a TERT expression regulator, a composition for diagnosing a TERT expression status, a diagnostic kit, a method for providing information for diagnosis, or a method for providing information for cancer diagnosis are disclosed. Specifically, in one aspect, the PROX1 of the present disclosure may bind to a TERT promoter, in particular a mutant TERT promoter in which base substitution occurs at the -124 or -146 bp position to regulate the expression of TERT, and the expression of TERT in non-hepatitis B virus-associated liver cancer can be inhibited specifically among liver cancers.

公开(公告)号：US20140120188A1

公开(公告)日：2014-05-01

申请号：US13661205

申请日：2012-10-26

Applicant: Korea Institute of Science and Technology

Inventor： Hyun Ok YANG ,  Hak Cheol KWON ,  Joon Ki KIM ,  Jin Wook CHA ,  Young-Joo KIM ,  Jungyeob HAM

IPC: A61K36/489 ,  A61P25/32

CPC classification number: A61K36/489 ,  A23L33/105 ,  A23V2002/00 ,  A61K2236/30 ,  A23V2200/334 ,  A23V2250/21

Abstract: A method of preventing or alleviating alcohol hangover, which comprises administering one or more selected from the group consisting of Sophora flavescens extracts, dried products of the extracts, and concentrates of the extracts to a subject in need of preventing or alleviating alcohol hangover is provided.

Abstract translation: 提供了一种预防或减轻酒精宿醉的方法，其包括向需要预防或减轻酒精宿醉的受试者施用一种或多种选自苦参提取物，提取物的干燥产物和提取物的浓缩物的一种或多种。

公开(公告)号：US20140087008A1

公开(公告)日：2014-03-27

申请号：US14038378

申请日：2013-09-26

Applicant: COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR) ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok YANG ,  Sung-Kwon CHUNG ,  Hak Cheol KWON ,  Jin Wook CHA ,  Vinesh Jaichand MAHARAJ ,  Rudzani NTHAMBELENI ,  Dashnie NAIDOO ,  Young-Joo KIM ,  Jungyeob HAM ,  Jeremiah SENABE ,  Gerda FOUCHE ,  Eric KHOROMBI ,  Joon Ki KIM

IPC: A61K36/185 ,  A23L2/52 ,  A23L1/30

CPC classification number: A61K36/185 ,  A23L2/52 ,  A23L33/105 ,  A61K2236/39

Abstract: The present invention relates to a pharmaceutical composition for preventing and/or treating dementia comprising extracts of Monsonia sp.; a food composition for preventing and/or improving dementia comprising extracts of Monsonia sp.; and a method of preparing an extract of Monsonia sp. with excellent inhibitory effect on the formation of β-amyloid. The plant extract can inhibit the formation of β-amyloid which has been known as a factor causing the dementia, especially Alzheimer's disease, thereby being used for preventing, improving and/or treating the dementia.

Abstract translation: 本发明涉及一种用于预防和/或治疗痴呆症的药物组合物，其包含麻黄属植物提取物。 一种用于预防和/或改善痴呆症的食物组合物，其包含孟山药的提取物。 和一种制备麻黄提取物的方法 对淀粉样蛋白的形成具有优异的抑制作用。 植物提取物可以抑制已知作为引起痴呆的因素，特别是阿尔茨海默氏病的β-淀粉样蛋白的形成，从而用于预防，改善和/或治疗痴呆。