公开(公告)号：US20230114565A1

公开(公告)日：2023-04-13

申请号：US17962026

申请日：2022-10-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Hak Cheol KWON ,  Jaeyoung KWON ,  Seong-Hwan KIM ,  Jin Wook CHA ,  Soon Kwang LEE ,  Won Kyu KIM ,  Yujin KWON ,  Suyeon CHO ,  Taek Joo LEE ,  Jung Hwa KANG ,  Wan Hee LEE ,  Hyunki KIM

IPC: A61K36/73 ,  A61K36/268 ,  A61P35/00 ,  A61P1/00

Abstract: Provided are compositions for preventing or treating cancer, the compositions including Rubus longisepalus var. tozawai (Nakai) T.B.Lee extracts, or a fraction thereof as an active ingredient.
According to an aspect, a Rubus longisepalus var. tozawai (Nakai) T.B.Lee extract has an excellent anticancer efficacy against various cancers including diffuse-type gastric cancer, and thus, a cancer treatment agent having an excellent effect may be developed by using the extract as an active ingredient.

公开(公告)号：US20230109869A1

公开(公告)日：2023-04-13

申请号：US17962092

申请日：2022-10-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Hak Cheol KWON ,  Jaeyoung KWON ,  Seong-Hwan KIM ,  Jung Hwan LEE ,  Jin Wook CHA ,  Ho Seong HWANG ,  Won Kyu KIM ,  Yujin KWON ,  Suyeon CHO ,  Taek Joo LEE ,  Jung Hwa KANG ,  Wan Hee LEE ,  Hyunki KIM

IPC: A61K36/268 ,  A61K36/73 ,  A61P35/00 ,  A61P1/00 ,  A23L33/105 ,  A23L33/00 ,  A23K10/30

Abstract: Provided are compositions for preventing or treating cancer including Asarum maculatum Nakai extracts, or a fraction thereof. According to an aspect, an Asarum maculatum Nakai extract has an excellent anticancer efficacy against various cancers including diffuse-type gastric cancer, and a cancer treatment agent having an excellent effect may be developed by using the extract as an active ingredient.

公开(公告)号：US20170056461A1

公开(公告)日：2017-03-02

申请号：US15242762

申请日：2016-08-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Wook LEE ,  Ju Young LEE ,  Jin Soo PARK ,  Jin Wook CHA ,  Hak Cheol KWON ,  Su-Nam KIM ,  Byung Hun UM

IPC: A61K36/28 ,  A23L33/105

CPC classification number: A61K36/28

Abstract: The present disclosure relates to a composition which comprises Centipede minima as an active ingredient. The composition of the present disclosure exhibits an effect of protecting neuronal cells from oxidative stress and inhibiting apoptosis of neuronal cells. In addition, the composition can increase expression of antioxidant enzymes which inhibit cellular apoptosis caused by increased oxidative stress in cells. Accordingly, the composition of the present disclosure can exhibit an effect of preventing, improving or treating secondary diseases that may be caused by apoptosis of neuronal cells due to oxidative stress and can be used as a pharmaceutical or food composition.

Abstract translation: 本公开涉及包含蜈蚣作为活性成分的组合物。 本公开的组合物显示出保护神经元细胞免受氧化应激和抑制神经元细胞凋亡的作用。 此外，该组合物可以增加抑制细胞中氧化应激增加引起的细胞凋亡的抗氧化酶的表达。 因此，本公开的组合物可以表现出预防，改善或治疗由于氧化应激可能由神经元细胞的凋亡引起的继发性疾病的作用，并且可以用作药物或食物组合物。

公开(公告)号：US20140120188A1

公开(公告)日：2014-05-01

申请号：US13661205

申请日：2012-10-26

Applicant: Korea Institute of Science and Technology

Inventor： Hyun Ok YANG ,  Hak Cheol KWON ,  Joon Ki KIM ,  Jin Wook CHA ,  Young-Joo KIM ,  Jungyeob HAM

IPC: A61K36/489 ,  A61P25/32

CPC classification number: A61K36/489 ,  A23L33/105 ,  A23V2002/00 ,  A61K2236/30 ,  A23V2200/334 ,  A23V2250/21

Abstract: A method of preventing or alleviating alcohol hangover, which comprises administering one or more selected from the group consisting of Sophora flavescens extracts, dried products of the extracts, and concentrates of the extracts to a subject in need of preventing or alleviating alcohol hangover is provided.

Abstract translation: 提供了一种预防或减轻酒精宿醉的方法，其包括向需要预防或减轻酒精宿醉的受试者施用一种或多种选自苦参提取物，提取物的干燥产物和提取物的浓缩物的一种或多种。

公开(公告)号：US20140087008A1

公开(公告)日：2014-03-27

申请号：US14038378

申请日：2013-09-26

Applicant: COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR) ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok YANG ,  Sung-Kwon CHUNG ,  Hak Cheol KWON ,  Jin Wook CHA ,  Vinesh Jaichand MAHARAJ ,  Rudzani NTHAMBELENI ,  Dashnie NAIDOO ,  Young-Joo KIM ,  Jungyeob HAM ,  Jeremiah SENABE ,  Gerda FOUCHE ,  Eric KHOROMBI ,  Joon Ki KIM

IPC: A61K36/185 ,  A23L2/52 ,  A23L1/30

CPC classification number: A61K36/185 ,  A23L2/52 ,  A23L33/105 ,  A61K2236/39

Abstract: The present invention relates to a pharmaceutical composition for preventing and/or treating dementia comprising extracts of Monsonia sp.; a food composition for preventing and/or improving dementia comprising extracts of Monsonia sp.; and a method of preparing an extract of Monsonia sp. with excellent inhibitory effect on the formation of β-amyloid. The plant extract can inhibit the formation of β-amyloid which has been known as a factor causing the dementia, especially Alzheimer's disease, thereby being used for preventing, improving and/or treating the dementia.

Abstract translation: 本发明涉及一种用于预防和/或治疗痴呆症的药物组合物，其包含麻黄属植物提取物。 一种用于预防和/或改善痴呆症的食物组合物，其包含孟山药的提取物。 和一种制备麻黄提取物的方法 对淀粉样蛋白的形成具有优异的抑制作用。 植物提取物可以抑制已知作为引起痴呆的因素，特别是阿尔茨海默氏病的β-淀粉样蛋白的形成，从而用于预防，改善和/或治疗痴呆。