公开(公告)号：US20210393723A1

公开(公告)日：2021-12-23

申请号：US17354380

申请日：2021-06-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyungsu KANG ,  Jae Young KWON ,  Hak Cheol KWON ,  Jin Chul KIM ,  Jin Soo PARK ,  Ho Seong HWANG ,  Seemi Tasnim ALAM

IPC: A61K36/28 ,  A61K41/00 ,  A61P31/04 ,  A61P31/10 ,  A01N65/12 ,  A61L2/00 ,  A61L2/26 ,  A61L2/08 ,  A61L2/10 ,  A23L3/3472 ,  A23L3/28 ,  A23B4/20 ,  A23B4/015 ,  A23B7/154 ,  A23B7/015 ,  C02F1/32 ,  C02F1/50

Abstract: Provided are methods of reducing and killing bacteria and fungi, and photodynamic treatment methods and sterilization methods using the methods of reducing and killing bacteria and fungi. The method of reducing and killing bacteria and fungi includes bringing a composition including a Ligularia fischeri extract or a fraction thereof as an active ingredient into contact with cells or tissues of a subject and irradiating cells or tissues of a subject in contact with the composition with an absorbable wavelength of excitation light.

公开(公告)号：US20140120188A1

公开(公告)日：2014-05-01

申请号：US13661205

申请日：2012-10-26

Applicant: Korea Institute of Science and Technology

Inventor： Hyun Ok YANG ,  Hak Cheol KWON ,  Joon Ki KIM ,  Jin Wook CHA ,  Young-Joo KIM ,  Jungyeob HAM

IPC: A61K36/489 ,  A61P25/32

CPC classification number: A61K36/489 ,  A23L33/105 ,  A23V2002/00 ,  A61K2236/30 ,  A23V2200/334 ,  A23V2250/21

Abstract: A method of preventing or alleviating alcohol hangover, which comprises administering one or more selected from the group consisting of Sophora flavescens extracts, dried products of the extracts, and concentrates of the extracts to a subject in need of preventing or alleviating alcohol hangover is provided.

Abstract translation: 提供了一种预防或减轻酒精宿醉的方法，其包括向需要预防或减轻酒精宿醉的受试者施用一种或多种选自苦参提取物，提取物的干燥产物和提取物的浓缩物的一种或多种。

公开(公告)号：US20140087008A1

公开(公告)日：2014-03-27

申请号：US14038378

申请日：2013-09-26

Applicant: COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR) ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok YANG ,  Sung-Kwon CHUNG ,  Hak Cheol KWON ,  Jin Wook CHA ,  Vinesh Jaichand MAHARAJ ,  Rudzani NTHAMBELENI ,  Dashnie NAIDOO ,  Young-Joo KIM ,  Jungyeob HAM ,  Jeremiah SENABE ,  Gerda FOUCHE ,  Eric KHOROMBI ,  Joon Ki KIM

IPC: A61K36/185 ,  A23L2/52 ,  A23L1/30

CPC classification number: A61K36/185 ,  A23L2/52 ,  A23L33/105 ,  A61K2236/39

Abstract: The present invention relates to a pharmaceutical composition for preventing and/or treating dementia comprising extracts of Monsonia sp.; a food composition for preventing and/or improving dementia comprising extracts of Monsonia sp.; and a method of preparing an extract of Monsonia sp. with excellent inhibitory effect on the formation of β-amyloid. The plant extract can inhibit the formation of β-amyloid which has been known as a factor causing the dementia, especially Alzheimer's disease, thereby being used for preventing, improving and/or treating the dementia.

Abstract translation: 本发明涉及一种用于预防和/或治疗痴呆症的药物组合物，其包含麻黄属植物提取物。 一种用于预防和/或改善痴呆症的食物组合物，其包含孟山药的提取物。 和一种制备麻黄提取物的方法 对淀粉样蛋白的形成具有优异的抑制作用。 植物提取物可以抑制已知作为引起痴呆的因素，特别是阿尔茨海默氏病的β-淀粉样蛋白的形成，从而用于预防，改善和/或治疗痴呆。

公开(公告)号：US20250099390A1

公开(公告)日：2025-03-27

申请号：US18730898

申请日：2023-01-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ki Young CHOI ,  Kwang-Hyun CHA ,  Hwa Seung HAN ,  Jin Soo PARK ,  Dae-geun SONG ,  Myung Suk KIM ,  Hak Cheol KWON

IPC: A61K9/50 ,  A61K35/74 ,  A61K35/745 ,  A61P37/06

Abstract: Provided is a method for preventing, ameliorating, or treating inflammatory diseases by administering a composition containing extracellular vesicles (EVs) derived from Roseburia spp. strains and/or Bifidobacterium spp. strains, wherein the EVs exhibits effectiveness in improving inflammatory bowel disease (IBD), and additionally, all EVs derived from congeneric strains corresponding to Roseburia spp. strains or Bifidobacterium spp. strains. have been confirmed to exhibit strong anti-inflammatory effect, and the strains and EVs derived therefrom can be provided as a composition for preventing, ameliorating, or treating a variety of inflammatory diseases.

公开(公告)号：US20210284677A1

公开(公告)日：2021-09-16

申请号：US17199651

申请日：2021-03-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok YANG ,  Hak Cheol KWON ,  Li Jun ZHANG ,  Jaeyoung KWON ,  Kee Beom KO

IPC: C07H15/24 ,  A61P25/28 ,  A61K9/00 ,  A23L33/105 ,  A23L33/00

Abstract: Provided are astersaponin I, which is a novel triterpene saponin derivative isolated and identified from a Aster koraiensis Nakai (Korean starwort) extract, and a use thereof for preventing or treating a neurodegenerative disorder.

公开(公告)号：US20230114565A1

公开(公告)日：2023-04-13

申请号：US17962026

申请日：2022-10-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Hak Cheol KWON ,  Jaeyoung KWON ,  Seong-Hwan KIM ,  Jin Wook CHA ,  Soon Kwang LEE ,  Won Kyu KIM ,  Yujin KWON ,  Suyeon CHO ,  Taek Joo LEE ,  Jung Hwa KANG ,  Wan Hee LEE ,  Hyunki KIM

IPC: A61K36/73 ,  A61K36/268 ,  A61P35/00 ,  A61P1/00

Abstract: Provided are compositions for preventing or treating cancer, the compositions including Rubus longisepalus var. tozawai (Nakai) T.B.Lee extracts, or a fraction thereof as an active ingredient.
According to an aspect, a Rubus longisepalus var. tozawai (Nakai) T.B.Lee extract has an excellent anticancer efficacy against various cancers including diffuse-type gastric cancer, and thus, a cancer treatment agent having an excellent effect may be developed by using the extract as an active ingredient.

公开(公告)号：US20210338759A1

公开(公告)日：2021-11-04

申请号：US17059595

申请日：2019-05-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  BIO-SYNERGY RESEARCH CENTER

Inventor： Hyun Ok YANG ,  Keon Wook KANG ,  Sung Won KWON ,  Jeong Hill PARK ,  Hocheol KIM ,  Myung Sook OH ,  Dae Sik JANG ,  Doheon LEE ,  Hak Cheol KWON ,  Byung Hwa JUNG

IPC: A61K36/54 ,  A61K36/268 ,  A61K36/346

Abstract: The present invention relates to a pharmaceutical composition for prevention or treatment of an allergic disease comprising a mixed extract of two or more selected from the group consisting of Asiasarum root, Platycodon root, and Cinnamomi ramulus as an active ingredient; a method for prevention or treatment of an allergic disease using the pharmaceutical composition; and a health functional food and a feed composition for improvement of an allergic disease.
The composition provided in the present invention comprising a mixed extract of two or more selected from the group consisting of Asiasarum root, Platycodon root, and Cinnamomi ramulus as an active ingredient can specifically inhibit the differentiation of Th2 cells and thus can be effectively used as a composition for prevention or treatment of an allergic disease.

公开(公告)号：US20190381122A1

公开(公告)日：2019-12-19

申请号：US16555950

申请日：2019-08-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Chu Won NHO ,  Hak Cheol KWON ,  Ji-Hye YOO ,  Jaeyoung KWON ,  Jin Soo PARK ,  Hyuk-Jai JANG ,  Seong-Su KIM ,  Cheon Soo PARK ,  Hwa-Mi LEE ,  Hee Ju LEE

IPC: A61K36/28 ,  A23L33/00 ,  A23L33/105

Abstract: Provided are a pharmaceutical composition including a Crepidiastrum denticulatum extract as an active ingredient; and a method for preventing or treating ischemia-reperfusion injury in a subject by using a food composition or the pharmaceutical composition.

公开(公告)号：US20230109869A1

公开(公告)日：2023-04-13

申请号：US17962092

申请日：2022-10-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Hak Cheol KWON ,  Jaeyoung KWON ,  Seong-Hwan KIM ,  Jung Hwan LEE ,  Jin Wook CHA ,  Ho Seong HWANG ,  Won Kyu KIM ,  Yujin KWON ,  Suyeon CHO ,  Taek Joo LEE ,  Jung Hwa KANG ,  Wan Hee LEE ,  Hyunki KIM

IPC: A61K36/268 ,  A61K36/73 ,  A61P35/00 ,  A61P1/00 ,  A23L33/105 ,  A23L33/00 ,  A23K10/30

Abstract: Provided are compositions for preventing or treating cancer including Asarum maculatum Nakai extracts, or a fraction thereof. According to an aspect, an Asarum maculatum Nakai extract has an excellent anticancer efficacy against various cancers including diffuse-type gastric cancer, and a cancer treatment agent having an excellent effect may be developed by using the extract as an active ingredient.

公开(公告)号：US20180085414A1

公开(公告)日：2018-03-29

申请号：US15717337

申请日：2017-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Chu Won NHO ,  Hak Cheol KWON ,  Ji-Hye YOO ,  Jaeyoung KWON ,  Jin Soo PARK ,  Hyuk-Jai JANG ,  Seong-Su KIM ,  Cheon Soo PARK ,  Hwa-Mi LEE ,  Hee Ju LEE

IPC: A61K36/28 ,  A23L33/105 ,  A23L33/00

CPC classification number: A61K36/28 ,  A23L33/105 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61P9/10

Abstract: Provided are a pharmaceutical composition including a Crepidiastrum denticulatum extract as an active ingredient; and a method for preventing or treating ischemia-reperfusion injury in a subject by using a food composition or the pharmaceutical composition.