公开(公告)号：US20230144344A1

公开(公告)日：2023-05-11

申请号：US17910894

申请日：2021-03-11

Applicant: SEOUL NATIONAL UNIVERSITY HOSPITAL ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Hyo-soo KIM ,  Hyun-duk JANG ,  Kyung Seop AHN ,  Sei-Ryang OH ,  Ok-Kyoung KWON ,  Hyung Won RYU ,  Hang JIN ,  Sangho CHOI ,  Sang Woo LEE ,  Jin Hyub PAIK ,  Soo Yong KIM ,  Changyoung LEE ,  Yong In KIM ,  Hyewon KIM ,  Mijin PARK

IPC: A61K36/185 ,  A61K31/7048 ,  A61P9/00

CPC classification number: A61K36/185 ,  A61K31/7048 ,  A61P9/00 ,  A61K2236/333 ,  A61K2236/35

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating cardiovascular and metabolic diseases, comprising an Elaeocarpus petiolatus extract, a fraction thereof, or a compound isolated therefrom, as an active ingredient; a food composition for preventing or improving cardiovascular and metabolic diseases; and a method for preventing or treating cardiovascular and metabolic diseases using the same.
The composition comprising an Elaeocarpus petiolatus extract, a fraction thereof, or a compound isolated therefrom inhibits the binding of Resistin-CAP1 to inhibit the production of tumor necrosis factor, and thereby has an activity of inhibiting inflammation of the cardiovascular system, and thus can be effectively used as a preventive or therapeutic measure for cardiovascular and metabolic diseases.

公开(公告)号：US20220000957A1

公开(公告)日：2022-01-06

申请号：US17283343

申请日：2019-10-08

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCiENCE AND BIOTECHNOLOGY

Inventor： Young Bae RYU ,  Sang Woo LEE ,  Sang Ho CHOI ,  Ji Young PARK ,  Hyung Jun KWON ,  In Chul LEE ,  Jong Sub LEE ,  Woo Song LEE ,  Wan Yi LI

IPC: A61K36/60 ,  A23L33/105 ,  A61P5/24

Abstract: The present invention relates to a pharmaceutical composition, food composition, and food additive for preventing or alleviating symptoms of andropause containing extract of Ficus auriculata Lour. as an active ingredient.
The extract of Ficus auriculata Lour. of the present invention exhibits the effect of preventing and alleviating erectile dysfunction by inhibiting the activity of PDE5, and the effect of preventing and alleviating prostatic hyperplasia by suppressing the expression of AR and PSA. Therefore, the extract of Ficus auriculata Lour. of the present invention may be usefully used as an active ingredient of a pharmaceutical composition, food composition, and food additive for alleviating symptoms of andropause.

公开(公告)号：US20170035822A1

公开(公告)日：2017-02-09

申请号：US15304316

申请日：2015-04-17

Applicant: Korea Research Institute of Bioscience and Biotechnology

Inventor： Sei Ryang OH ,  Kyung Seop AHN ,  Seung Hyung KIM ,  In Sik SHIN ,  Hang JIN ,  Jung Hee KIM ,  Hyung Won RYU ,  Wan Yi LI ,  Sang Woo LEE ,  Joong Ku LEE ,  Sang Ho CHOI

IPC: A61K36/22 ,  A61K9/00 ,  A23L33/105 ,  A61K31/12

Abstract: The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom; a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-α, or MIP-2. In addition, due to the use of a safety-proven herbal drug as a raw material, the composition of the present invention can resolve various side-effects of existing therapeutic agents for COPD, chronic obstructive bronchitis, chronic bronchiolitis, emphysema, multiple sclerosis, and acute and chronic inflammation, and thus can be effectively used as a composition for preventing, treating and remedying COPD.

Abstract translation: 本发明涉及一种抑制慢性阻塞性肺疾病（COPD）的组合物，其包含维斯特氏菌提取物，其分数或从其分离的化合物，更具体地，涉及用于预防或治疗COPD的药物组合物，所述药物组合物包含猕猴桃提取物（Pistacia weinmannifolia extract） ，其一部分，或从其分离的化合物; 用于预防或改善COPD的食物组合物和从其分离的化合物。 根据本发明的包含猕猴桃提取物，其馏分或从其分离的化合物的组合物是无毒的，抑制炎性细胞侵入COPD诱导的动物模型的支气管中，并有效地抑制 CXCL-1，TNF-α或MIP-2的表达。 此外，由于使用经安全验证的草药作为原料，本发明的组合物可以解决现有的COPD治疗剂，慢性阻塞性支气管炎，慢性细支气管炎，肺气肿，多发性硬化症， 和急性和慢性炎症，因此可以有效地用作预防，治疗和治疗COPD的组合物。