公开(公告)号：US20200283364A1

公开(公告)日：2020-09-10

申请号：US16632592

申请日：2018-07-19

申请人： Korea University Research and Business Foundation, Sejong Campus ,  Korea University Research and Business Foundation

发明人： Youngjoo BYUN ,  Hee-Deung PARK ,  Sang-Hyun SON ,  Eunji CHA ,  So-Young HAM ,  Hyunsuk CHOI

IPC分类号： C07C49/255 ,  C07C49/245 ,  A61P31/04

摘要： The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.