公开(公告)号：US11345936B2

公开(公告)日：2022-05-31

申请号：US17004863

申请日：2020-08-27

Applicant: LESAFFRE et COMPAGNIE

Inventor： Alexander Matthias Farwick ,  Thomas Desfougeres ,  Georges Pignede ,  Anaïs Roussel ,  Isabelle Mouly ,  Brieuc Morvan

IPC: C12P7/26 ,  C07C49/245 ,  C12N1/16 ,  C12N1/18 ,  C12N9/02 ,  C12N9/10 ,  C12N15/52 ,  C12P7/22 ,  C12R1/865

Abstract: The invention relates to a genetically modified fungal microorganism for the production of frambinone, the microorganism having the following characteristics: —the capacity to produce frambinone from tyrosine; and —a limited capacity or no capacity to break tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate; and to the use of same for producing frambinone.

公开(公告)号：US09803187B2

公开(公告)日：2017-10-31

申请号：US14717096

申请日：2015-05-20

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  Asociación Instituto Nacional de Biodiversidad

Inventor： David H. Sherman ,  Ashootosh Tripathi ,  Michael Marie Kaufman-Schofield ,  Giselle Tamayo ,  Pam Schultz

IPC: C12N9/99 ,  C07C49/248 ,  C07C49/245 ,  C07C49/217 ,  C07C45/79 ,  C12N9/00 ,  A61K31/12 ,  C12N1/20

CPC classification number: C12N9/99 ,  A61K31/12 ,  C07C45/79 ,  C07C49/217 ,  C07C49/245 ,  C07C49/248 ,  C12N9/93

Abstract: Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of Streptomyces tempisquensis.

公开(公告)号：US20050004401A1

公开(公告)日：2005-01-06

申请号：US10611394

申请日：2003-07-01

Applicant: Scott Barnicki ,  Jennifer McCusker-Orth ,  Jerry Miller

Inventor： Scott Barnicki ,  Jennifer McCusker-Orth ,  Jerry Miller

IPC: C07C45/72 ,  C07C45/74 ,  C07C49/17 ,  C07C49/203 ,  C07C49/235 ,  C07C49/245 ,  C07C49/807

CPC classification number: C07C49/807 ,  C07C45/72 ,  C07C45/74 ,  C07C47/19 ,  C07C49/17 ,  C07C49/21 ,  C07C49/203 ,  C07C47/21

Abstract: Processes for producing β-hydroxy-ketones and α,β-unsaturated ketones are disclosed which comprise the crossed condensation of an aldehyde with a ketone in the presence of a hydroxide or alkoxide of alkali metal or an alkaline earth metal as catalyst. The products of the process, β-hydroxy-ketones and α,β-unsaturated ketones, are useful for the preparation of many commercially important products in the chemical process industries including solvents, drug intermediates, flavors and fragrances, other specialty chemical intermediates.

公开(公告)号：US5710342A

公开(公告)日：1998-01-20

申请号：US568054

申请日：1995-12-06

Applicant: Laszlo Imre ,  Reinhard Schomacker ,  Judit Daun

Inventor： Laszlo Imre ,  Reinhard Schomacker ,  Judit Daun

IPC: B01J27/13 ,  B01J27/24 ,  C07B41/06 ,  C07B61/00 ,  C07C45/34 ,  C07C45/35 ,  C07C47/07 ,  C07C49/04 ,  C07C49/16 ,  C07C49/17 ,  C07C49/213 ,  C07C49/233 ,  C07C49/245 ,  C07C201/12 ,  C07C205/45 ,  C07C255/56

CPC classification number: C07C45/34 ,  C07C45/35

Abstract: Carbonyl compounds can be prepared by catalytic oxidation of olefins with oxygen or oxygen-containing gases in a microemulsion (ME) as reaction medium and catalyst support. The catalysts present in ME and used for this purpose are characterized by a content of 0.0001-10% by weight of a Pd compound and by a content of 0.0005-20% by weight of a subgroup metal compound or a quinone, based on the total weight of the catalysts present in the ME.

Abstract translation: 羰基化合物可以通过在作为反应介质和催化剂载体的微乳液（ME）中的含氧气体或含氧气体的烯烃的催化氧化来制备。 存在于ME中并用于该目的的催化剂的特征在于，以化合物的总重量计，0.0001-20重量％的Pd化合物和0.0005〜20重量％的亚金属化合物或醌的含量 存在于ME中的催化剂的重量。

公开(公告)号：US5210315A

公开(公告)日：1993-05-11

申请号：US779529

申请日：1991-10-18

Applicant: Takao Saito ,  Hidenori Kumobayashi ,  Shunichi Murahashi

Inventor： Takao Saito ,  Hidenori Kumobayashi ,  Shunichi Murahashi

IPC: C07C45/28 ,  C07C45/30 ,  C07C49/245 ,  C07C49/337 ,  C07C49/493 ,  C07C49/497 ,  C07C49/503 ,  C07C49/713 ,  C07C49/747 ,  C07C49/82 ,  C07C67/29 ,  C07C67/313 ,  C07D303/16 ,  C07J9/00 ,  C07J71/00

CPC classification number: C07J71/001 ,  C07C45/28 ,  C07C45/30 ,  C07C49/245 ,  C07C49/337 ,  C07C49/493 ,  C07C49/497 ,  C07C49/503 ,  C07C49/713 ,  C07C49/747 ,  C07C49/82 ,  C07C67/29 ,  C07C67/313 ,  C07D303/16 ,  C07J9/00

Abstract: A process for producing an .alpha.-hydroxyketone represented by formula (I): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aralkyl group, or an alkoxycarbonyl group; and R.sup.2 and R.sup.3 each represent a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aralkyl group, provided that they do not simultaneously represent a hydrogen atom; or a pair of R.sup.1 and R.sup.2, a pair of R.sup.1 and R.sup.3, or a pair of R.sup.2 and R.sup.3 is taken together to form a ring; and the pair of R.sup.1 and R.sup.2 and the pair of R.sup.2 and R.sup.3 may form a ring simultaneously, is disclosed, comprising reacting a compound represented by formula (II): ##STR2## wherein R.sup.1, R.sup.2, and R.sup.3 are as defined above, with an oxidizing agent in the presence of a ruthenium compound and water. .alpha.-Hydroxyketones useful as physiologically active substances are produced with good selectivity and in high yield.

公开(公告)号：US5071898A

公开(公告)日：1991-12-10

申请号：US360801

申请日：1989-06-02

Applicant: Hermann O. Wirth ,  Hans-Helmut Friedrich ,  Gerd Abeler

Inventor： Hermann O. Wirth ,  Hans-Helmut Friedrich ,  Gerd Abeler

IPC: C07C45/00 ,  C07C45/57 ,  C07C45/59 ,  C07C45/60 ,  C07C49/17 ,  C07C49/245 ,  C07C49/82 ,  C07C67/00 ,  C08K5/07 ,  C08K5/57

CPC classification number: C07C49/82 ,  C07C45/57 ,  C07C45/59 ,  C07C45/60 ,  C07C49/17 ,  C07C49/245 ,  C08K5/07

Abstract: Composition containing a) a polymer containing chlorine and b) at least one compound of the formula I ##STR1## in which R.sub.1 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 hydroxyalkyl, phenyl, hydroxyphenyl, C.sub.7 -C.sub.10 phenylalkyl or C.sub.7 -C.sub.10 phenylalkyl which is substituted on the phenyl ring by an OH group, and R.sub.2 is C.sub.2 -C.sub.10 hydroxyalkyl, hydroxyphenyl or C.sub.7 -C.sub.10 phenylalkyl which is substituted on the phenyl ring by an OH group, subject to the condition that R.sub.2 is other than hydroxyphenyl if R.sub.1 is phenyl or hydroxyphenyl, and/or at least one compound of the formula I in which the OH groups present in the radicals R.sub.1 and R.sub.2 have been replaced by C.sub.2 -C.sub.12 alkanoyloxy.The compounds of the formula IA ##STR2## in which R is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 hydroxyalkyl, phenyl, hydroxyphenyl, C.sub.7 -C.sub.10 phenylalkyl or C.sub.7 -C.sub.10 phenylalkyl which is substituted on the phenyl ring by an OH group, are novel.

Abstract translation: 含有a）含氯的聚合物和b）至少一种式I的化合物其中R 1是C 1 -C 10烷基，C 2 -C 10羟烷基，苯基，羟基苯基，C 7 -C 10苯基烷基或C 7 -C 10苯基烷基，其是 在苯基环上被OH基取代，R2是在苯环上被OH基取代的C2-C10羟烷基，羟基苯基或C7-C10苯基烷基，条件是如果R1是苯基或羟基苯基，则R2不是羟基苯基 ，和/或至少一种其中存在于基团R 1和R 2中的OH基团被C 2 -C 12烷酰氧基取代的式I化合物。 其中R是在OH基上在苯环上取代的C 1 -C 10烷基，C 2 -C 10羟基烷基，苯基，羟基苯基，C 7 -C 10苯基烷基或C 7 -C 10苯基烷基的式IA（IA）化合物。

公开(公告)号：US4963590A

公开(公告)日：1990-10-16

申请号：US126911

申请日：1987-11-27

Applicant: Reijo J. Backstrom ,  Kalevi E. Heinola ,  Erkki J. Honkanen ,  Seppo K. Kaakkola ,  Pekka J. Kairisalo ,  Inge-Britt Y. Linden ,  Pekka T. Mannisto ,  Erkki A. O. Nissinen ,  Pentti Pohto ,  Aino K. Pippuri ,  Jarmo J. Pystynen

Inventor： Reijo J. Backstrom ,  Kalevi E. Heinola ,  Erkki J. Honkanen ,  Seppo K. Kaakkola ,  Pekka J. Kairisalo ,  Inge-Britt Y. Linden ,  Pekka T. Mannisto ,  Erkki A. O. Nissinen ,  Pentti Pohto ,  Aino K. Pippuri ,  Jarmo J. Pystynen

IPC: C07C27/00 ,  A61K31/00 ,  A61K31/04 ,  A61K31/045 ,  A61K31/047 ,  A61K31/05 ,  A61K31/06 ,  A61K31/075 ,  A61K31/085 ,  A61K31/11 ,  A61K31/12 ,  A61K31/13 ,  A61K31/135 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/235 ,  A61K31/275 ,  A61K31/33 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61K31/395 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/47 ,  A61K31/495 ,  A61P9/12 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P43/00 ,  C07C20060101 ,  C07C39/08 ,  C07C39/24 ,  C07C39/26 ,  C07C39/373 ,  C07C43/20 ,  C07C43/23 ,  C07C45/00 ,  C07C45/56 ,  C07C45/67 ,  C07C45/74 ,  C07C47/52 ,  C07C47/565 ,  C07C47/575 ,  C07C49/20 ,  C07C49/245 ,  C07C49/747 ,  C07C49/76 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07C59/40 ,  C07C59/52 ,  C07C59/56 ,  C07C59/64 ,  C07C59/68 ,  C07C59/90 ,  C07C65/00 ,  C07C65/03 ,  C07C65/21 ,  C07C67/00 ,  C07C69/017 ,  C07C69/035 ,  C07C69/73 ,  C07C69/76 ,  C07C205/20 ,  C07C205/22 ,  C07C205/23 ,  C07C205/26 ,  C07C205/34 ,  C07C205/37 ,  C07C205/43 ,  C07C205/45 ,  C07C205/56 ,  C07C205/57 ,  C07C213/00 ,  C07C231/00 ,  C07C233/00 ,  C07C233/12 ,  C07C235/44 ,  C07C235/54 ,  C07C235/66 ,  C07C239/00 ,  C07C253/00 ,  C07C255/37 ,  C07C255/53 ,  C07C301/00 ,  C07C309/65 ,  C07C311/15 ,  C07C317/22 ,  C07D207/32 ,  C07D207/325 ,  C07D207/333 ,  C07D211/14 ,  C07D211/22 ,  C07D211/30 ,  C07D211/32 ,  C07D211/58 ,  C07D213/30 ,  C07D215/14 ,  C07D295/08 ,  C07D295/13 ,  C07D295/18 ,  C07D295/185 ,  C07D317/52 ,  C07D317/62 ,  C07D319/24 ,  C07D405/04 ,  C07D405/06

CPC classification number: C07D207/333 ,  C07C205/22 ,  C07C205/23 ,  C07C205/26 ,  C07C205/34 ,  C07C205/37 ,  C07C205/43 ,  C07C205/45 ,  C07C205/56 ,  C07C205/57 ,  C07C255/00 ,  C07C317/00 ,  C07C323/00 ,  C07C43/23 ,  C07C45/565 ,  C07C45/673 ,  C07C45/74 ,  C07C47/565 ,  C07C47/575 ,  C07C49/835 ,  C07C49/84 ,  C07C59/56 ,  C07C59/64 ,  C07C59/68 ,  C07D211/32 ,  C07D211/58 ,  C07D213/30 ,  C07D215/14 ,  C07D295/13 ,  C07D295/185 ,  C07D317/62 ,  C07D319/24 ,  C07D405/04

Abstract: Pharmacologically active catechol derivatives of formula I ##STR1## wherein R.sub.1 and R.sub.2 independently comprise hydrogen, alkyl, acyl, optionally substituted aroyl, lower alkylsulfonyl or alkylcabamoyl or taken together form a lower alkylidene or cycloalkylidene, X comprises an electronegative substituent such as halogen, nitro, cyano, lower alkylsulfonyl, sulfonamido, aldehyde, caboxyl or trifluoromethyl and R.sub.3 comprises hydrogen, halogen, hydroxy alkyl, amino, nitro, cyano, trifluoromethyl, lower alkylsulfonyl, sulfonamide, aldehyde, alkyl carbonyl, aralkylidene carbonyl or carboxyl or a group selected from ##STR2## wherein R.sub.4 comprises hydrogen, alkyl, cyano, carboxyl or acyl and R.sub.5 comprises hydrogen, cyano, carboxyl, alkoxycarbonyl, carboxyalkenyl, nitro, acyl, optionally substituted aroyl or heteroaroyl, hydroxyalkyl or carboxyalkyl or R.sub.4 and R.sub.5 together form a five to seven membered substituted cycloalkanone ring;--(CO).sub.n (CH.sub.2).sub.m --CORwherein n is 0-1 and m is 0-7 and R comprises hydroxy, alkyl, carboxyalkyl, optionally substituted alkene, alkoxy or optionally substituted amino; ##STR3## wherein R.sub.8 and R.sub.9 independently comprise hydrogen or one of the following optionally substituted groups; alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, or together form an optionally substituted piperidyl group;--NH--CO--R.sub.10wherein R.sub.10 comprises a substituted alkyl group.

Abstract translation: 式I的药理活性儿茶酚衍生物其中R 1和R 2独立地包括氢，烷基，酰基，任选取代的芳酰基，低级烷基磺酰基或烷基氨基甲酰基，或一起形成低级亚烷基或环烷叉基，X包括电负性取代基如卤素， 硝基，氰基，低级烷基磺酰基，亚磺酰氨基，醛，呋喃甲酰基或三氟甲基，R3包括氢，卤素，羟基烷基，氨基，硝基，氰基，三氟甲基，低级烷基磺酰基，磺酰胺，醛，烷基羰基，亚烷基羰基或羧基或选自 其中R 4包括氢，烷基，氰基，羧基或酰基，R 5包括氢，氰基，羧基，烷氧基羰基，羧基烯基，硝基，酰基，任选取代的芳酰基或杂芳酰基，羟基烷基或羧基烷基或R4和R5一起形成五 至七元取代的环烷酮环; - （CO）n（CH 2）m -COR其中n为0-1，m为0-7，R为羟基，烷基，羧基烷基，任选取代的烯烃，烷氧基或任选取代的氨基; 其中R8和R9独立地包含氢或以下任选取代的基团之一; 烷基，烯基，炔基，环烷基，芳烷基，或一起形成任选取代的哌啶基; -NH-CO-R 10，其中R 10包含取代的烷基。

公开(公告)号：US4873329A

公开(公告)日：1989-10-10

申请号：US704038

申请日：1985-02-21

Applicant: Leslie R. Hughes ,  John Oldfield ,  Howard Tucker

Inventor： Leslie R. Hughes ,  John Oldfield ,  Howard Tucker

IPC: A61K31/045 ,  A61K31/075 ,  A61K31/095 ,  A61K31/10 ,  A61K31/12 ,  A61K31/135 ,  A61K31/165 ,  A61K31/18 ,  A61K31/22 ,  A61K31/235 ,  A61K31/27 ,  A61K31/275 ,  A61K31/44 ,  A61K31/47 ,  A61K31/473 ,  A61K31/52 ,  A61P17/00 ,  C07C17/23 ,  C07C17/26 ,  C07C33/28 ,  C07C33/34 ,  C07C33/40 ,  C07C33/48 ,  C07C33/50 ,  C07C43/14 ,  C07C43/20 ,  C07C43/23 ,  C07C45/26 ,  C07C45/54 ,  C07C45/72 ,  C07C45/74 ,  C07C47/273 ,  C07C49/213 ,  C07C49/227 ,  C07C49/235 ,  C07C49/245 ,  C07C49/248 ,  C07C49/255 ,  C07C59/56 ,  C07C69/02 ,  C07C205/19 ,  C07C205/26 ,  C07C205/34 ,  C07C215/28 ,  C07C215/68 ,  C07C235/06 ,  C07C255/32 ,  C07C255/53 ,  C07C317/00 ,  C07D213/34 ,  C07D213/57 ,  C07D213/61 ,  C07D213/70 ,  C07D213/71 ,  C07D215/06 ,  C07D215/14 ,  C07D215/16 ,  C07D215/36 ,  C07D219/04 ,  C07D219/16 ,  C07D233/84 ,  C07D239/38 ,  C07D239/46 ,  C07D239/47 ,  C07D239/56 ,  C07D249/12 ,  C07D251/38 ,  C07D277/24 ,  C07D277/36 ,  C07D303/08 ,  C07D333/16 ,  C07D333/28 ,  C07D333/38 ,  C07D333/44 ,  C07D339/06 ,  C07D339/08 ,  C07D473/00 ,  C07D473/24 ,  C07D473/38 ,  C07D487/04 ,  C07D521/00 ,  C07F7/08

CPC classification number: C07C17/23 ,  C07C17/278 ,  C07C205/26 ,  C07C205/45 ,  C07C255/00 ,  C07C317/00 ,  C07C323/00 ,  C07C33/483 ,  C07C33/50 ,  C07C45/26 ,  C07C45/54 ,  C07C45/72 ,  C07C45/74 ,  C07C47/273 ,  C07C49/235 ,  C07C49/245 ,  C07C49/248 ,  C07C59/56 ,  C07D213/34 ,  C07D213/57 ,  C07D213/61 ,  C07D213/70 ,  C07D213/71 ,  C07D215/14 ,  C07D215/36 ,  C07D219/04 ,  C07D233/84 ,  C07D239/38 ,  C07D239/47 ,  C07D239/56 ,  C07D249/12 ,  C07D251/38 ,  C07D277/24 ,  C07D277/36 ,  C07D303/08 ,  C07D333/28 ,  C07D333/38 ,  C07D333/44 ,  C07D339/06 ,  C07D473/24 ,  C07D473/38 ,  C07D487/04 ,  C07F7/0818

Abstract: A compound of the formula ##STR1## wherein X has the formula ##STR2## wherein ring A is phenyl, naphthyl or heterocyclic; wherein R.sup.1 is hydrogen, alkyl, alkanoyl or aroyl; wherein R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each is an electron withdrawing substituent selected from halogeno, nitro, cyano, trifluoromethyl, alkylthio, alkylsulphinyl and alkylsulphonyl or each is hydrogen, alkyl, alkoxy or dialkylamino provided that when ring A is phenyl or naphthyl at least one of R.sup.2, R.sup.3 and R.sup.4 is an electron-withdrawing substituent; wherein R.sup.5 and R.sup.6, which may be the same or different, each is hydrogen, halogeno or alkyl; wherein R.sup.7 is alkyl or halogenoalkyl; and wherein R.sup.8 is carbamoyl, alkyl, cycloalkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalkenyl, halogenoalkynyl, alkanoyl, alkylcarbamoyl, dialkylcarbamoyl or aroyl; or wherein R.sup.8 is alkyl or alkenyl which bears one or more substituents selected from cyano, carbamoyl, amino, hydroxy, alkanoyl, alkoxy, alkylthio, alkenylthio, alkylsulphinyl, alkenylsulphinyl, alkylsulphonyl, alkenylsulphonyl, alkanoylamino, alkoxycarbonylamino, alkylsulphonamido, alkylamino, dialkylamino, dialkylsulphamoyl, aroyl, aryl, arylthio, arylsulphinyl, arylsulphonyl, heterocyclylthio, heterocyclylsulphinyl and heterocyclylsulphonyl; or wherein R.sup.8 has the formula ##STR3## wherein ring B is phenyl, naphthyl or heterocyclyl and wherein R.sup.2, R.sup.3 and R.sup.4 have any of the meanings stated above, provided that when R.sup.7 is methyl R.sup.8 is not also methyl.

Abstract translation: 式（I）的化合物，其中X具有式“IMAGE”，其中环A是苯基，萘基或杂环基; 其中R1是氢，烷基，烷酰基或芳酰基; 其中R 2，R 3和R 4可以相同或不同，各自为选自卤素，硝基，氰基，三氟甲基，烷硫基，烷基亚磺酰基和烷基磺酰基的吸电子取代基，或者各自为氢，烷基，烷氧基或二烷基氨基，条件是当环 A是苯基或萘基，R 2，R 3和R 4中的至少一个是吸电子取代基; 其中R 5和R 6可以相同或不同，各自为氢，卤代或烷基; 其中R 7是烷基或卤代烷基; 并且其中R8是氨基甲酰基，烷基，环烷基，烯基，炔基，卤代烷基，卤代烯基，卤代炔基，烷酰基，烷基氨基甲酰基，二烷基氨基甲酰基或芳酰基。 或其中R8是具有一个或多个选自氰基，氨基甲酰基，氨基，羟基，烷酰基，烷氧基，烷硫基，烯硫基，烷基亚磺酰基，烯基亚磺酰基，烷基磺酰基，烯基磺酰基，烷酰基氨基，烷氧基羰基氨基，烷基磺酰氨基，烷基氨基，二烷基氨基，二烷基氨基磺酰基 ，芳酰基，芳基，芳硫基，芳基亚磺酰基，芳基磺酰基，杂环硫基，杂环基亚磺酰基和杂环基磺酰基; 或其中R 8具有式“IMAGE”，其中环B为苯基，萘基或杂环基，并且其中R2，R3和R4具有上述任何含义，条件是当R 7为甲基时，R 8也不是甲基。

公开(公告)号：US4814162A

公开(公告)日：1989-03-21

申请号：US798364

申请日：1985-11-18

Applicant: Gerald Lang ,  Alain Malaval ,  Madeleine Leduc

Inventor： Gerald Lang ,  Alain Malaval ,  Madeleine Leduc

IPC: A61K8/00 ,  A61K8/33 ,  A61K8/35 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q1/12 ,  A61Q3/02 ,  A61Q5/02 ,  A61Q5/10 ,  A61Q17/04 ,  C07C45/54 ,  C07C49/245 ,  C07C49/255 ,  C07C49/76 ,  C07C49/82 ,  C07C49/83 ,  C07C49/84 ,  A61K7/42 ,  A61K7/44 ,  A61K9/10 ,  A61K9/12

CPC classification number: A61Q17/04 ,  A61K8/35 ,  C07C45/54 ,  C07C49/83 ,  C07C49/84 ,  Y10S424/04 ,  Y10S514/937 ,  Y10S514/943 ,  Y10S514/944 ,  Y10S514/969 ,  Y10S514/972

Abstract: A cosmetic composition is disclosed containing, as an agent for protection against light radiation, at least one 2-hydroxydibenzoylmethane of the formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently of one another denote hydrogen or halogen atoms, a straight-chain or branched-chain C.sub.1 to C.sub.12 alkyl group or a C.sub.1 to C.sub.4 lower alkoxy group and R denotes a hydrogen atom or a C.sub.1 to C.sub.4 lower alkyl group, in a cosmetically acceptable medium.

Abstract translation: 公开了一种化妆品组合物，其包含作为光辐射防护剂的至少一种下式所示的2-羟基二苯甲酰甲烷：其中R 1，R 2，R 3和R 4彼此独立地表示氢或卤素原子 ，直链或支链C1至C12烷基或C1至C4低级烷氧基，R表示氢原子或C1至C4低级烷基，在化妆品可接受的介质中。

公开(公告)号：US4532356A

公开(公告)日：1985-07-30

申请号：US552284

申请日：1983-11-16

Applicant: Charles R. Everly ,  Jerry M. Roper

Inventor： Charles R. Everly ,  Jerry M. Roper

IPC: C07C45/68 ,  C07C49/245 ,  C07C45/61

CPC classification number: C07C49/245 ,  C07C45/68

Abstract: Novel bis(3',5'-mono or dihydrocarbyl-4'-hydroxybenzyl)-1,3-diketones are prepared by reacting a (3',5'-mono or dihydrocarbyl-4'-hydroxybenzyl)-1,3-diketone with an N,N-dihydrocarbyl-2,6-mono or dihydrocarbyl-4-aminomethylphenol and an alkyl halide in the presence of an alkaline earth metal halide. The products are useful as antioxidants.

Abstract translation: 通过使（3'，5'-单或二烃基-4'-羟基苄基）-1,3-二酮反应，制备新的双（3'，5'-单或二烃基-4'-羟基苄基）-1,3-二酮 在碱土金属卤化物存在下与N，N-二烃基-2,6-单或二烃基-4-氨基甲基苯酚和烷基卤二酮进行反应。 该产品可用作抗氧化剂。