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公开(公告)号:US20080311107A1
公开(公告)日:2008-12-18
申请号:US11814136
申请日:2007-02-09
申请人: Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel A. Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Trac Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
发明人: Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel A. Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Trac Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
CPC分类号: A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译: 本发明涉及转基因动物,以及与基因功能表征相关的组合物和方法。 具体地,本发明提供转基因小鼠,其包括在PRO188,PRO235,PRO266,PRO337,PRO361,PRO539,PRO698,PRO717,PRO846,PRO874,PRO98346,PRO1082,PRO1097,PRO1192,PRO1268,PRO1278,PRO1303,PRO1308,PRO1338,PRO1378中的中断 ,PRO1415,PRO1867,PRO1890,PRO3438,PRO19835,PRO36915,PRO36029,PRO4999,PRO5778,PRO5997,PRO6079,PRO6090,PRO7178,PRO21184,PRO7434,PRO9822,PRO9833,PRO9836,PRO9854,PRO9862,PRO10284,PRO37510,PRO35444,PRO20473,PRO21054 或PRO35246基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防,改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管,内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。