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1.发明授权Transdermal systems containing multilayer adhesive matrices to modify drug delivery 有权包含多层粘合剂基质以改变药物递送的透皮系统公开(公告)号：US09492401B2
公开(公告)日：2016-11-15
申请号：US12979120
申请日：2010-12-27
CPC分类号： A61K9/7092 , A61F13/00 , A61F2013/00646 , A61F2013/00655 , A61F2013/0071 , A61F2013/00906 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/565 , A61K31/567 , A61M37/00 , Y10T156/10
摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix.The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.
摘要翻译： 第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。 通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。
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2.发明申请TRANSDERMAL SYSTEMS CONTAINING MULTILAYER ADHESIVE MATRICES TO MODIFY DRUG DELIVERY 有权包含多层粘合剂基体的变态系统修改药物递送公开(公告)号：US20110151003A1
公开(公告)日：2011-06-23
申请号：US12979120
申请日：2010-12-27
IPC分类号： A61K9/14 , A61K31/56 , A61K31/445 , B32B38/10 , B32B37/02
CPC分类号： A61K9/7092 , A61F13/00 , A61F2013/00646 , A61F2013/00655 , A61F2013/0071 , A61F2013/00906 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/565 , A61K31/567 , A61M37/00 , Y10T156/10
摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix.The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.
摘要翻译： 含透皮药物的剂量单位包括：基本上不透过经皮递送的药物的背衬层; 与背衬层接触的第一聚合物粘合剂基质，其中分散有药物并具有药物的第一递送曲线; 与所述第一聚合物粘合剂基质接触的第二聚合物粘合剂基质，其中分散有药物并具有药物的第二递送分布，其中所述第二递送分布与所述第一递送分布不同; 以及与第二聚合物粘合剂基质接触的剥离衬垫。 第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。 通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。
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公开(公告)号：US20110106022A1
公开(公告)日：2011-05-05
申请号：US13004604
申请日：2011-01-11
IPC分类号： A61M35/00
CPC分类号： A61L15/44 , A61K9/7061 , A61L15/585 , A61L2300/602
摘要： A medical grade adhesive comprises a mixture of at least one cross-linkable pressure sensitive adhesive component and at least one non-cross-linkable pressure-sensitive adhesive component, wherein the amount of each of said components is such that the resultant adhesive can adhere to human skin for a period of up to about 7-10 days but can be removed without causing trauma to the skin.
摘要翻译： 医用级粘合剂包括至少一种可交联压敏粘合剂组分和至少一种不可交联的压敏粘合剂组分的混合物，其中每种所述组分的量使得所得粘合剂可以粘附到 人体皮肤长达约7-10天，但可以去除而不会对皮肤造成伤害。
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公开(公告)号：US07888422B2
公开(公告)日：2011-02-15
申请号：US11594224
申请日：2006-11-08
IPC分类号： C08L33/06
CPC分类号： A61L15/44 , A61K9/7061 , A61L15/585 , A61L2300/602
摘要： A medical grade adhesive comprises a mixture of at least one cross-linkable pressure sensitive adhesive component and at least one non-cross-linkable pressure-sensitive adhesive component, wherein the amount of each of said components is such that the resultant adhesive can adhere to human skin for a period of up to about 7-10 days but can be removed without causing trauma to the skin.
摘要翻译： 医用级粘合剂包括至少一种可交联压敏粘合剂组分和至少一种不可交联的压敏粘合剂组分的混合物，其中每种所述组分的量使得所得粘合剂可以粘附到 人体皮肤长达约7-10天，但可以去除而不会对皮肤造成伤害。
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公开(公告)号：US08614274B2
公开(公告)日：2013-12-24
申请号：US13004604
申请日：2011-01-11
IPC分类号： C08L3/00
CPC分类号： A61L15/44 , A61K9/7061 , A61L15/585 , A61L2300/602
摘要： A medical grade adhesive comprises a mixture of at least one cross-linkable pressure sensitive adhesive component and at least one non-cross-linkable pressure-sensitive adhesive component, wherein the amount of each of said components is such that the resultant adhesive can adhere to human skin for a period of up to about 7-10 days but can be removed without causing trauma to the skin.
摘要翻译： 医用级粘合剂包括至少一种可交联压敏粘合剂组分和至少一种不可交联的压敏粘合剂组分的混合物，其中每种所述组分的量使得所得粘合剂可以粘附到 人体皮肤长达约7-10天，但可以去除而不会对皮肤造成伤害。
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6.发明申请Transdermal Systems Containing Multilayer Adhesive Matrices to Modify Drug Delivery 审中-公开包含多层粘合剂基质的透皮系统来改变药物递送公开(公告)号：US20080305155A1
公开(公告)日：2008-12-11
申请号：US12057728
申请日：2008-03-28
IPC分类号： A61F13/02 , A61K31/566 , A61K31/565 , A61K31/57 , A61K31/445 , A61K31/454 , A61K31/4468
CPC分类号： A61K9/7092 , A61F13/00 , A61F2013/00646 , A61F2013/00655 , A61F2013/0071 , A61F2013/00906 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/565 , A61K31/567 , A61M37/00 , Y10T156/10
摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix.The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.
摘要翻译： 含透皮药物的剂量单位包括：基本上不透过经皮递送的药物的背衬层; 与背衬层接触的第一聚合物粘合剂基质，其中分散有药物并具有药物的第一递送曲线; 与所述第一聚合物粘合剂基质接触的第二聚合物粘合剂基质，其中分散有药物并具有药物的第二递送分布，其中所述第二递送分布与所述第一递送分布不同; 以及与第二聚合物粘合剂基质接触的剥离衬垫。 第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。 通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。
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