公开(公告)号：US20240398994A1

公开(公告)日：2024-12-05

申请号：US18407581

申请日：2024-01-09

Applicant: Krystal Biotech, Inc.

Inventor： Suma Krishnan ,  Trevor Parry ,  Dana Michelle Previte ,  Mary Jane Duermeyer

IPC: A61K48/00 ,  A61K38/19 ,  A61K38/20 ,  A61P35/00 ,  C12N7/00 ,  C12N15/86

Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding an immunomodulatory polypeptide (e.g., a pro-inflammatory cytokine such as a human IL-2 or IL-12 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of cancer, such as lung cancer); and articles of manufacture or kits thereof.

公开(公告)号：US11918660B2

公开(公告)日：2024-03-05

申请号：US18180791

申请日：2023-03-08

Applicant: Krystal Biotech, Inc.

Inventor： Suma Krishnan ,  Trevor Parry ,  Dana Michelle Previte ,  Mary Jane Duermeyer

IPC: C12N15/869 ,  A61K35/763 ,  A61K38/19 ,  A61K38/20 ,  A61K48/00 ,  A61P35/00 ,  C12N7/00 ,  C12N15/24 ,  C12N15/26 ,  C12N15/86

CPC classification number: A61K48/0066 ,  A61K38/193 ,  A61K38/2013 ,  A61K38/208 ,  A61P35/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16622 ,  C12N2710/16633 ,  C12N2710/16643 ,  C12N2710/16662 ,  C12N2710/16671

Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding an immunomodulatory polypeptide (e.g., a pro-inflammatory cytokine such as a human IL-2 or IL-12 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of cancer, such as lung cancer); and articles of manufacture or kits thereof.

公开(公告)号：US11779660B2

公开(公告)日：2023-10-10

申请号：US17711947

申请日：2022-04-01

Applicant: Krystal Biotech, Inc.

Inventor： Suma Krishnan ,  Trevor Parry ,  Dana Michelle Previte ,  Mary Jane Duermeyer

IPC: A61K35/763 ,  A61K48/00 ,  A61K38/19 ,  A61P35/00 ,  C12N7/00 ,  C12N15/24 ,  A61K38/20 ,  C12N15/86

CPC classification number: A61K48/0066 ,  A61K38/193 ,  A61K38/208 ,  A61K38/2013 ,  A61P35/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16622 ,  C12N2710/16633 ,  C12N2710/16643 ,  C12N2710/16662 ,  C12N2710/16671

Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding an immunomodulatory polypeptide (e.g., a pro-inflammatory cytokine such as a human IL-2 or IL-12 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of cancer, such as lung cancer); and articles of manufacture or kits thereof.