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公开(公告)号：US09149446B2
公开(公告)日：2015-10-06
申请号：US13217128
申请日：2011-08-24
IPC分类号： A61K31/07 , A61K38/17 , A61K31/11 , A61K31/382 , A61K31/435 , A61K31/695
CPC分类号： A61K31/11 , A61K9/0048 , A61K31/07 , A61K31/382 , A61K31/435 , A61K31/695 , A61K38/1709 , Y10S514/912
摘要： Methods and compositions for stabilizing opsin protein, such as a Pro23His mutant opsin protein, in a vertebrate visual system, by administration of opsin-binding synthetic retinoids, are provided. The mutant opsin protein binds to the synthetic retinoid, which stabilizes the mutant opsin protein and/or ameliorates the effects of the mutant opsin protein on the vertebrate visual system.
摘要翻译： 提供了通过施用视蛋白结合合成的类视色素在脊椎动物视觉系统中稳定视蛋白蛋白如Pro23His突变视蛋白的方法和组合物。 突变视蛋白蛋白结合合成的类视色素，其稳定突变视蛋白蛋白和/或改善突变视蛋白对脊椎动物视觉系统的影响。
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公开(公告)号：US20130072443A1
公开(公告)日：2013-03-21
申请号：US13619238
申请日：2012-09-14
IPC分类号： A61K38/17
CPC分类号： A61K31/11 , A61K9/0048 , A61K31/07 , A61K31/382 , A61K31/435 , A61K31/695 , A61K38/1709 , Y10S514/912
摘要： Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids.
摘要翻译： 通过施用视蛋白结合合成类维生素A来提供在脊椎动物视觉系统中稳定视蛋白蛋白的方法和组合物。
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3.发明申请Compositions and Methods for Treating or Preventing Ophthalmic Light Toxicity 审中-公开治疗或预防眼睛光毒性的组合物和方法公开(公告)号：US20090291919A1
公开(公告)日：2009-11-26
申请号：US12357036
申请日：2009-01-21
申请人： Shalesh Kaushal , Syed M. Noorwez
发明人： Shalesh Kaushal , Syed M. Noorwez
IPC分类号： A61K31/07 , A61K31/355 , A61K31/375 , A61K31/415 , A61K31/44 , A61K31/506 , A61K31/4965 , A61K31/662 , A61K31/13 , A61K31/12
CPC分类号： A61K31/11
摘要： Methods are disclosed for treating ophthalmic conditions related to the production of toxic visual cycle products that accumulate in the eye, and are associated with reactions of the visual cycle during medical procedures that expose the eye to light, most commonly the various forms of ophthalmic surgery. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described, along with methods of screening for new agents useful in said treatments.
摘要翻译： 公开了用于治疗与在眼睛中累积的毒性视觉循环产物的生产有关的眼科疾病的方法，并且与将眼睛暴露于光的医学过程中的视觉循环的反应相关联，最常见的是各种形式的眼科手术。 还描述了可用于这些方法的化合物和组合物，单独或与其它治疗剂组合，以及筛选用于所述治疗的新试剂的方法。
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公开(公告)号：US20090286808A1
公开(公告)日：2009-11-19
申请号：US12356967
申请日：2009-01-21
IPC分类号： A61K31/4965 , A61K31/505 , A61K31/44 , A61K31/415 , A61K31/11 , C07K1/107
CPC分类号： A61K31/415 , A61K31/513
摘要： The present invention provides compositions and methods useful in the treatment and/or prevention of ophthalmic conditions and diseases, such as retinitis pigmentosa, that are dependent upon or related to misfolded opsin proteins in vivo. In addition, screening assays for agents useful in such treatment methods are described.
摘要翻译： 本发明提供了用于治疗和/或预防眼科疾病和疾病如视网膜色素变性的组合物和方法，其依赖于或与体内错误折叠的视蛋白蛋白有关。 此外，描述了可用于这种治疗方法的试剂的筛选测定。
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