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公开(公告)号：US09447502B2
公开(公告)日：2016-09-20
申请号：US13266075
申请日：2009-04-30
申请人： Kunihiko Koike , Yasumichi Kogai , Masami Nakagawa
发明人： Kunihiko Koike , Yasumichi Kogai , Masami Nakagawa
CPC分类号： C23C22/05 , C08K3/32 , C09D1/00 , C23C18/04 , C23C18/122 , C23C18/1241 , C23C22/78 , C23C22/83 , C23C2222/20
摘要： Provided is a means for fixing calcium phosphate onto the surface of a metal by a treatment method which uses no acid and produces less residue. A method of producing a calcium phosphate composite in which calcium phosphate is bonded to the surface of a base material, the method including a surface treatment step of bringing the surface of the base material into contact with a surface treating agent, and then into contact with a silane coupling agent, to surface treat the base material; a polymerization step of initiating, after the surface treatment step, polymerization of the silane coupling agent by means of a polymerization initiator; and a bonding step of bonding the silane coupling agent at the surface of the base material after the polymerization step, with calcium phosphate; wherein the base material is a metal, and the surface treating agent is ozone water.
摘要翻译： 提供通过不使用酸并且产生较少残留物的处理方法将磷酸钙固定在金属表面上的方法。 一种磷酸钙复合体的制造方法，其中磷酸钙结合到基材的表面，该方法包括使基材表面与表面处理剂接触的表面处理步骤，然后与 硅烷偶联剂，用于表面处理基材; 在表面处理步骤之后，通过聚合引发剂使硅烷偶联剂聚合的聚合步骤; 以及在聚合步骤之后将硅烷偶联剂与基体材料的表面与磷酸钙接合的粘合步骤; 所述基材为金属，所述表面处理剂为臭氧水。
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公开(公告)号：US20120114832A1
公开(公告)日：2012-05-10
申请号：US13266075
申请日：2009-04-30
申请人： Kunihiko Koike , Yasumichi Kogai , Masami Nakagawa
发明人： Kunihiko Koike , Yasumichi Kogai , Masami Nakagawa
IPC分类号： A61L33/06
CPC分类号： C23C22/05 , C08K3/32 , C09D1/00 , C23C18/04 , C23C18/122 , C23C18/1241 , C23C22/78 , C23C22/83 , C23C2222/20
摘要： Provided is a means for fixing calcium phosphate onto the surface of a metal by a treatment method which uses no acid and produces less residue. A method of producing a calcium phosphate composite in which calcium phosphate is bonded to the surface of a base material, the method including a surface treatment step of bringing the surface of the base material into contact with a surface treating agent, and then into contact with a silane coupling agent, to surface treat the base material; a polymerization step of initiating, after the surface treatment step, polymerization of the silane coupling agent by means of a polymerization initiator; and a bonding step of bonding the silane coupling agent at the surface of the base material after the polymerization step, with calcium phosphate; wherein the base material is a metal, and the surface treating agent is ozone water.
摘要翻译： 提供通过不使用酸并且产生较少残留物的处理方法将磷酸钙固定在金属表面上的方法。 一种磷酸钙复合体的制造方法，其中磷酸钙结合到基材的表面，该方法包括使基材表面与表面处理剂接触的表面处理步骤，然后与 硅烷偶联剂，用于表面处理基材; 在表面处理步骤之后，通过聚合引发剂使硅烷偶联剂聚合的聚合步骤; 以及在聚合步骤之后将硅烷偶联剂与基体材料的表面与磷酸钙接合的粘合步骤; 所述基材为金属，所述表面处理剂为臭氧水。
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公开(公告)号：US20130273166A1
公开(公告)日：2013-10-17
申请号：US13989865
申请日：2011-12-01
IPC分类号： A61K33/42
CPC分类号： A61K33/42 , A61K8/0241 , A61K8/24 , A61K2800/412 , A61Q19/00
摘要： A method for enlarging a breast includes the step of administering to a subject in need thereof a composition that includes a fine particle of calcium phosphate. The fine particle of calcium phosphate may be a fine particle of hydroxyapatite. An average particle size of the fine particle of calcium phosphate is 10 to 1,000 nm. The fine particle of calcium phosphate may be a sintered body. The sintered body may be manufactured by a method including: a mixing step in which a primary particle containing calcium phosphate is mixed with a fusion inhibitor, and a sintering step in which the mixed particle obtained by the mixing step defined above is exposed to a sintering temperature.
摘要翻译： 扩大乳房的方法包括向有需要的受试者施用包含磷酸钙细颗粒的组合物的步骤。 磷酸钙的细颗粒可以是羟基磷灰石的细颗粒。 磷酸钙微粒的平均粒径为10〜1000nm。 磷酸钙的微粒可以是烧结体。 烧结体可以通过以下方法制造：包含磷酸钙的一次粒子与熔融抑制剂混合的混合工序，将烧结工序，将通过上述混合工序得到的混合粒子暴露于烧结体 温度。
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公开(公告)号：US20120128788A1
公开(公告)日：2012-05-24
申请号：US13321964
申请日：2009-05-26
CPC分类号： A61K8/24 , A61K8/0245 , A61K8/025 , A61K31/047 , A61K31/19 , A61K31/70 , A61K31/715 , A61K33/42 , A61K45/06 , A61K2800/413 , A61K2800/651 , A61Q19/08 , Y10T428/2982 , A61K2300/00
摘要： A collagen production enhancer for increasing the amount of collagen contained in the skin tissues, comprising calcium phosphate fine particles as effective ingredients.
摘要翻译： 一种用于增加皮肤组织中含有的胶原蛋白量的胶原蛋白生产增强剂，其包含磷酸钙细颗粒作为有效成分。
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公开(公告)号：US20120064343A1
公开(公告)日：2012-03-15
申请号：US13257494
申请日：2009-03-19
CPC分类号： A61K8/24 , A61K6/0017 , A61K6/033 , A61K2800/413 , A61Q11/00 , Y10T428/2982
摘要： Provided is a tooth surface repairing material which can produce an effect in a short time while preventing fine particles from shedding. The tooth surface repairing material contains fine calcium phosphate particles, and is characterized in that the fine calcium phosphate particles are highly crystalline sintered calcium phosphate and have an average particle diameter in the range of 20-100 nm.
摘要翻译： 提供了可以在短时间内产生效果，同时防止细颗粒脱落的牙齿表面修复材料。 牙齿表面修复材料含有细小的磷酸钙颗粒，其特征在于，细磷酸钙颗粒是高度结晶的烧结磷酸钙，其平均粒径在20-100nm的范围内。
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