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    Cephalosporin derivatives
    5.
    发明授权
    Cephalosporin derivatives 失效
    头孢菌素衍生物

    公开(公告)号：US4785090A

    公开(公告)日：1988-11-15

    申请号：US704077

    申请日：1985-02-21

    申请人： Takashi Tsuruoka ,  Seiji Shibahara ,  Katsuyoshi Iwamatsu ,  Tsuneo Okonogi ,  Satoru Nakabayashi ,  Yasushi Murai ,  Hiroko Ogino ,  Kiyoaki Katano ,  Takashi Yoshida ,  Shigeharu Inoue ,  Shunzo Fukatsu ,  Shinichi Kondo

    发明人： Takashi Tsuruoka ,  Seiji Shibahara ,  Katsuyoshi Iwamatsu ,  Tsuneo Okonogi ,  Satoru Nakabayashi ,  Yasushi Murai ,  Hiroko Ogino ,  Kiyoaki Katano ,  Takashi Yoshida ,  Shigeharu Inoue ,  Shunzo Fukatsu ,  Shinichi Kondo

    IPC分类号： C07D213/64 ,  C07D213/68 ,  C07D221/04 ,  C07D501/36 ,  C07D501/38 ,  A61K31/545

    CPC分类号： C07D221/04 ,  C07D213/64 ,  C07D213/68

    摘要： This is a class of antibacterial compounds of the formula: ##STR1## wherein Y is straight or branched alkyl or alkenyl chain, cycloalkanomethyl of 3-6 carbon atoms, each group being optionally substituted by halogen, or a group ##STR2## wherein n is 0 or an integer of 1-3, A is a group --COR.sup.3 wherein R.sup.3 is hydroxy, a group ##STR3## wherein R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or alkyl of 1-5 carbon atoms, a group ##STR4## or a 5- or 6-membered heterocyclic group containing nitrogen and/or sulfur, and R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, alkyl of 1-5 carbon atoms, or R.sup.1 and R.sup.2 may be combined together to form cycloalkylidene of 3-5 carbon atoms, and Z is a group of the formula: ##STR5## wherein m is 0 or an integer of 3-5, R.sup.6 is hydrogen or alkyl of 1-3 carbon atoms, and R.sup.7, when m is an integer of 3-5, is alkyl of 1-5 carbon atoms, alkenyl, cyclopropyl, a group --(CH.sub.2).sub.p B wherein p is 0 or an integer of 1-3 and B is amino, alkyl-substituted amino, hydroxy, carboxy, carbamoyl, trifluoromethyl, sulfonic acid, sulfonic acid amide, alkylthio or cyano or, when m is 0, is alkyl of 1-5 carbon atoms, which may optionally be substituted by halogen, alkenyl, a group ##STR6## wherein R.sup.8 is hydrogen, alkyl of 1-4 carbon atoms or phenyl, or cyclopropyl, and a salt thereof.

    摘要翻译： 这是一类具有下式的抗菌化合物：其中Y是直链或支链烷基或烯基链，3-6个碳原子的环烷基甲基，每个基团任选被卤素取代，或基团< 其中n为0或1-3的整数，A为基团-COR 3，其中R 3为羟基，其中R 4和R 5可以相同或不同，为氢或1-5碳的烷基 原子，基团或含有氮和/或硫的5-或6-元杂环基，R 1和R 2可以相同或不同，为氢，1-5个碳原子的烷基或R1 并且R 2可以组合在一起形成3-5个碳原子的亚烷基，Z是下式的基团：其中m是0或3-5的整数，R6是氢或1-3个碳的烷基 原子和R 7，当m是3-5的整数时，是1-5个碳原子的烷基，烯基，环丙基，基团 - （CH 2）pB，其中p是0或1-3的整数，B是氨基 ，烷基取代的氨基 羟基，羧基，氨基甲酰基，三氟甲基，磺酸，磺酸酰胺，烷硫基或氰基，或当m为0时，其为1-5个碳原子的烷基，其可任选被卤素，链烯基，基团 其中R8是氢，1-4个碳原子的烷基或苯基，或环丙基及其盐。

    Cephalosporin compounds and the production thereof
    7.
    发明授权
    Cephalosporin compounds and the production thereof 失效
    头孢菌素化合物及其生产

    公开(公告)号：US4839350A

    公开(公告)日：1989-06-13

    申请号：US36124

    申请日：1987-04-07

    申请人： Kunio Atsumi ,  Kenji Sakagami ,  Yuichi Yamamoto ,  Takashi Yoshida ,  Ken Nishihata ,  Shinichi Kondo ,  Shunzo Fukatsu

    发明人： Kunio Atsumi ,  Kenji Sakagami ,  Yuichi Yamamoto ,  Takashi Yoshida ,  Ken Nishihata ,  Shinichi Kondo ,  Shunzo Fukatsu

    IPC分类号： C07D277/32 ,  C07D501/22 ,  C07D501/24

    CPC分类号： C07D277/32 ,  Y02P20/55

    摘要： A class of new caphalosporin compounds (syn-isomer) is now provided, which is useful as antibacterial agent and is represented by the general formula (I) ##STR1## wherein R.sup.1 is an amino group or a protected amino group; R.sup.2 is a lower alkyl group, a carboxymethyl group or a protected carboxymethyl group; R.sup.3 is a hydrogen atom, a salt-forming cation or a carboxyl-protecting group; A is an unsubstituted or substituted phenyl group, an unsubstituted or substituted furyl group, an unsubstituted or substituted thiazolyl group or an unsubstituted or substituted 3-lower-alkylthiazolio group, and a pharmaceutically acceptable salt or ester thereof.

    摘要翻译： 现在提供一类新的头孢菌素化合物（顺式异构体），其可用作抗菌剂并由通式（I）表示，其中R 1是氨基或被保护的氨基; R2是低级烷基，羧甲基或受保护的羧甲基; R3是氢原子，成盐阳离子或羧基保护基; A是未取代或取代的苯基，未取代或取代的呋喃基，未取代或取代的噻唑基或未取代或取代的3-低级烷基噻唑基及其药学上可接受的盐或酯。

    Cephalosporin compounds
    8.
    发明授权
    Cephalosporin compounds 失效
    头孢菌素化合物

    公开(公告)号：US4791197A

    公开(公告)日：1988-12-13

    申请号：US751208

    申请日：1985-07-02

    申请人： Kenji Sakagami ,  Kunio Atsumi ,  Ken Nishihata ,  Takashi Yoshida ,  Shunzo Fukatsu

    发明人： Kenji Sakagami ,  Kunio Atsumi ,  Ken Nishihata ,  Takashi Yoshida ,  Shunzo Fukatsu

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D277/38 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D501/59 ,  C07D501/22

    CPC分类号： C07D277/20 ,  Y02P20/55

    摘要： A new cephalosporin compound is now provided, which is useful as antibacterial agent and is represented by the general formula (I) ##STR1## wherein R.sup.1 is an amino group or a protected amino group; R.sup.2 is a hydrogen atom, a salt-forming cation or a carboxyl-protecting group; R.sup.3 is a hydrogen atom, a halogen atom, a lower alkylthio group, a lower alkoxyl group, a vinyl group or a group of the formula: --CH.sub.2 Y where Y is a hydrogen atom, a halogen atom, an acyloxy group, an unsubstituted or substituted heterocyclic thio group or an unsubstituted or substituted pyridinio group, and a pharmaceutically acceptable salt or ester thereof.

    摘要翻译： 现提供一种新的头孢菌素化合物，其可用作抗菌剂并由通式（I）表示，其中R 1是氨基或被保护的氨基; R2是氢原子，成盐阳离子或羧基保护基; R3是氢原子，卤素原子，低级烷硫基，低级烷氧基，乙烯基或下式基团：-CH2Y其中Y是氢原子，卤素原子，酰氧基，未取代的或未取代的 取代的杂环硫基或未取代或取代的吡啶并基及其药学上可接受的盐或酯。

    Cephem compounds
    9.
    发明授权
    Cephem compounds 失效
    头孢烯化合物

    公开(公告)号：US4918068A

    公开(公告)日：1990-04-17

    申请号：US19172

    申请日：1987-02-26

    申请人： Yuichi Yamamoto ,  Kunio Atsumi ,  Kenji Sakagami ,  Takashi Yoshida ,  Ken Nishihata ,  Sinichi Kondo

    发明人： Yuichi Yamamoto ,  Kunio Atsumi ,  Kenji Sakagami ,  Takashi Yoshida ,  Ken Nishihata ,  Sinichi Kondo

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/24

    CPC分类号： C07D501/24

    摘要： There are provided new cephem compounds (synisomers) represented by the following general formula (I): ##STR1## wherein R.sup.1 means a lower group, R.sup.2 denotes an ester-forming group of the carboxyl group, and the 4-methylthiazolyl group and the cephem moiety are cis to each other relative to the carbon-carbon double bond of the substituted vinyl group in the side chain at the 3-position of the cephem nucleus. The cephem compounds exhibit strong antibacterial activities not only against resistant strains of bacteria and gram-negative bacteria but also against gram-positive bacteria and moreover have very low toxicity.

    摘要翻译： 提供了由以下通式（I）表示的新的头孢烯化合物（异构体）：其中R1表示低级基团，R2表示羧基的酯形成基团，4-甲基噻唑基 并且头孢烯部分相对于头孢烯核的3位侧链中取代的乙烯基的碳 - 碳双键彼此是顺式的。 头孢类化合物不仅抗细菌和革兰氏阴性细菌的抗性菌株，而且对革兰氏阳性细菌具有很强的抗菌活性，而且毒性非常低。

    Vibration transducer and its manufacturing method
    10.
    发明授权
    Vibration transducer and its manufacturing method 有权
    振动传感器及其制造方法

    公开(公告)号：US09063023B2

    公开(公告)日：2015-06-23

    申请号：US13228855

    申请日：2011-09-09

    申请人： Takashi Yoshida

    发明人： Takashi Yoshida

    IPC分类号： G01L9/08 ,  G01H13/00 ,  G01L9/00 ,  G01L1/10 ,  B81B3/00

    CPC分类号： G01L9/0019 ,  B81B3/001 ,  B81B2201/025 ,  B81B2201/0264 ,  B81B2201/0285 ,  B81B2203/0118 ,  G01L1/106 ,  G01L9/0013 ,  H03H9/2457 ,  H03H2009/02496

    摘要： A vibration transducer includes a silicon single crystal vibration beam provided over a silicon single crystal substrate, the vibration beam having a sectional shape that is longer in a direction perpendicular to a surface of the silicon single crystal substrate than in a direction parallel with it, a shell made of silicon, surrounding the vibration beam with a gap, and forming a vacuum room together with the silicon single crystal substrate, a plate-like first electrode plate disposed parallel with the surface of the silicon single crystal substrate, the first electrode plate having one end connected to the vibration beam, plate-like second and third electrode plates disposed parallel with the surface of the silicon single crystal substrate so as to be opposed to each other with the vibration beam interposed in between, and asperities formed on confronting side surfaces of the vibration beam and the second and third electrode plates.

    摘要翻译： 振动传感器包括设置在硅单晶衬底上的硅单晶振动束，所述振动束具有在垂直于所述硅单晶衬底的表面的方向上比在与其平行的方向上更长的截面形状， 由硅制成的壳体，围绕振动梁间隙，并与硅单晶基板一起形成真空室，与硅单晶基板的表面平行布置的板状第一电极板，第一电极板具有 一端与振动束相连接，板状的第二和第三电极板与硅单晶衬底的表面平行设置，以便彼此相对地插入振动束，并且形成在相对侧面上的凹凸 的振动束和第二和第三电极板。