公开(公告)号：US5164401A

公开(公告)日：1992-11-17

申请号：US714886

申请日：1991-06-17

申请人： Kurt Burow ,  Gerd Buschmann ,  Arman Farjam ,  Ulrich Kuehl ,  Gerda Varchmin ,  Deiter Ziegler ,  Uwe Schoen

发明人： Kurt Burow ,  Gerd Buschmann ,  Arman Farjam ,  Ulrich Kuehl ,  Gerda Varchmin ,  Deiter Ziegler ,  Uwe Schoen

IPC分类号： A61K31/435 ,  A61K31/439 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  C07D471/08 ,  C07D471/10

CPC分类号： C07D471/08 ,  Y10S514/869

摘要： A method of treating a mammal in need of diruetic treatment by administering an effective diuretic amount of a diuretically active 3,7,9,9-tetrasubstituted 3,7-diazabicyclo[3,3,1]nonane compound, diuretic pharmaceutical compositions containing an effective diuretic amount of a diuretically active 3,7,9,9-tetrasubstituted 3,7-diazabicyclo[3,3,1]nonane compound; and previously unknown diuretically active 3,7,9,9-tetrasubstituted 3,7-diazabicyclo[3,3,1]nonane compounds containing an optionally substituted phenylalkyl group in the 3-position.

摘要翻译： 通过施用有效的利尿剂量的利尿剂活性的3,7,9,9-四取代的3,7-二氮杂双环[3,3,1]壬烷化合物来治疗需要diruetic治疗的哺乳动物的方法，所述利尿药物组合物含有 有利的利尿剂量的利尿剂活性的3,7,9,9-四取代的3,7-二氮杂双环[3,3,1]壬烷化合物; 和在3-位含有任选取代的苯基烷基的以前未知的具有利尿作用的3,7,9,9-四取代3,7-二氮杂双环[3,3,1]壬烷化合物。

公开(公告)号：US5635511A

公开(公告)日：1997-06-03

申请号：US594946

申请日：1996-01-31

申请人： Uwe Schoen ,  Arman Farjam ,  Reinhard Brueckner ,  Dieter Ziegler

发明人： Uwe Schoen ,  Arman Farjam ,  Reinhard Brueckner ,  Dieter Ziegler

IPC分类号： A61K31/435 ,  A61K31/439 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D471/08 ,  C07D471/10 ,  A61K31/44

CPC分类号： C07D471/08 ,  C07D471/10

摘要： The use of 3,7,9,9-tetrasubstituted 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds for treating cardiac arrhytmias in larger mammals, including humans; novel antiarrhythmically active 3,7,9,9-tetrasubstituted compounds corresponding to the general formula Ia ##STR1## in which R.sup.1 is an alkyl group having 1-6 carbon atoms or a cycloalkylalkyl group having 4-7 carbon atoms,R.sup.2 is lower alkyl, andR.sup.3 is lower alkyl, orR.sup.2 and R.sup.3 together form an alkylene chain having 3-6 carbon atoms,R.sup.4' is cyano, an R.sup.6 --O--CO-- group in which R.sup.6 is lower alkyl, an R.sup.7 --SO.sub.2 --NH-- group in which R.sup.7 is lower alkyl, or an R.sup.8 --CO--NH-- group in which R.sup.8 is lower alkyl or a phenyl group which is optionally substituted by halogen, cyano, nitro, or an R.sup.9 --SO.sub.2 -- radical in which R.sup.9 is lower alkyl, or an imidazolyl radical located in position 4 of the phenyl ring, andR.sup.5 is hydrogen or halogen,and physiologically acceptable acid addition salts thereof, and processes and intermediates for preparing them.

摘要翻译： 使用3,7,9,9-四取代的3-苯基磺酰基-3,7-二氮杂双环[3.3.1]壬烷化合物治疗大型哺乳动物，包括人类的心脏病变; 对应于其中R 1为具有1-6个碳原子的烷基或具有4-7个碳原子的环烷基烷基的通式Ia Ia的新型抗心律失活的3,7,9,9-四取代化合物，R2较低 烷基，R3为低级烷基，或R2和R3一起形成3-6个碳原子的亚烷基链，R4'为氰基，R6为低级烷基的R6-O-CO-基团，R7-SO2-NH - 其中R 7为低级烷基的基团，或其中R 8为低级烷基的R 8 -CO-NH基或任选被卤素，氰基，硝基或R 9 -SO 2 - 基团取代的苯基，其中R 9为 低级烷基或位于苯环4位的咪唑基，R5为氢或卤素，以及其生理上可接受的酸加成盐，以及制备它们的方法和中间体。

公开(公告)号：US5576327A

公开(公告)日：1996-11-19

申请号：US382262

申请日：1995-02-01

申请人： Uwe Schoen ,  Arman Farjam ,  Reinhard Brueckner ,  Dieter Ziegler

发明人： Uwe Schoen ,  Arman Farjam ,  Reinhard Brueckner ,  Dieter Ziegler

IPC分类号： A61K31/435 ,  A61K31/439 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D471/08 ,  C07D471/10

CPC分类号： C07D471/08 ,  C07D471/10

摘要： The use of 3,7,9,9-tetrasubstituted 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds for treating cardiac arrhythmias in larger mammals, including humans; novel antiarrhythmically active 3,7,9,9-tetrasubstituted compounds corresponding to the general formula Ia ##STR1## in which R.sup.1 is an alkyl group having 1-6 carbon atoms or a cycloalkylalkyl group having 4-7 carbon atoms,R.sup.2 is lower alkyl, andR.sup.3 is lower alkyl, orR.sup.2 and R.sup.3 together form an alkylene chain having 3-6 carbon atoms,R.sup.4 ' is cyano, an R.sup.6 --O--CO-- group in which R.sup.6 is lower alkyl, an R.sup.7 --SO.sub.2 --NH-- group in which R.sup.7 is lower alkyl, or an R.sup.8 --CO--NH-- group in which R.sup.8 is lower alkyl or a phenyl group which is optionally substituted by halogen, cyano, nitro or an R.sup.9 --SO.sub.2 -- radical in which R.sup.9 is lower alkyl, or an imidazolyl radical located in position 4 of the phenyl ring, andR.sup.5 is hydrogen or halogen,and physiologically acceptable acid addition salts thereof, and processes and intermediates for preparing them.

摘要翻译： 使用3,7,9,9-四取代的3-苯基磺酰基-3,7-二氮杂双环[3.3.1]壬烷化合物治疗大型哺乳动物，包括人类的心律失常; 对应于其中R 1为具有1-6个碳原子的烷基或具有4-7个碳原子的环烷基烷基的通式Ia Ia的新型抗心律失活的3,7,9,9-四取代化合物，R2较低 烷基，R3为低级烷基，或R2和R3一起形成3-6个碳原子的亚烷基链，R4'为氰基，R6为低级烷基的R6-O-CO-基团，R7-SO2-NH - 其中R 7为低级烷基的基团，或其中R 8为低级烷基的R 8 -CO-NH-基团或任选被卤素，氰基，硝基或R 9 -SO 2 - 基团取代的苯基，其中R 9为低级 烷基或位于苯环4位的咪唑基，R5为氢或卤素，以及其生理上可接受的酸加成盐，以及其制备方法和中间体。