公开(公告)号：US09534245B2

公开(公告)日：2017-01-03

申请号：US12989375

申请日：2008-04-23

申请人： Kurt Dirk Bettenhausen ,  Shun Jie Fan ,  Herbert Grieb ,  Jun Feng Jiang ,  Hongwei Yang ,  Yue Zhuo

发明人： Kurt Dirk Bettenhausen ,  Shun Jie Fan ,  Herbert Grieb ,  Jun Feng Jiang ,  Hongwei Yang ,  Yue Zhuo

IPC分类号： C12M1/36 ,  C12Q1/06 ,  C12Q1/02 ,  G01N33/50 ,  G01N33/569 ,  C12M1/34 ,  C12M1/00

CPC分类号： C12Q1/02 ,  C12M41/46 ,  C12M41/48 ,  C12M43/00 ,  G01N33/5005 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/56966

摘要： A method and device for controlling a fermenting process, wherein the method comprises collecting samples of biological cells from a fermenting tank, obtaining the state information of the current biological cells based on the collected samples, comparing the state information of the current biological cells with preset target status information to obtain the difference between the state information of the current biological cells and preset target state information, and controlling the feed rate of nutritional solution into the fermenting tank. Real time control of biological fermenting process is thus accomplished based on the state information of the biological cells during fermentation, and the consistency during fermentation is improved. Complicated mathematical modeling and man-made data analysis are not required for the method and device. Real time control of biological fermenting process is accomplished based on a feedback loop with simply calculation, and control delay is not created, and automatic control of cells statement in fermentation is achieved.

摘要翻译： 一种用于控制发酵过程的方法和装置，其中所述方法包括从发酵罐收集生物细胞的样品，基于收集的样品获得当前生物细胞的状态信息，将当前生物细胞的状态信息与预设 目标状态信息以获得当前生物细胞的状态信息与预设目标状态信息之间的差异，以及控制营养液进入发酵罐的进料速率。 基于发酵过程中生物细胞的状态信息，实现了生物发酵过程的实时控制，提高了发酵过程中的一致性。 方法和设备不需要复杂的数学建模和人为数据分析。 生物发酵过程的实时控制是通过简单计算的反馈回路实现的，控制延迟不会产生，实现发酵过程中细胞声明的自动控制。

公开(公告)号：US20110039297A1

公开(公告)日：2011-02-17

申请号：US12989375

申请日：2008-04-23

申请人： Shun Jie Fan ,  Hongwei Yang ,  Jun Feng Jiang ,  Herbert Grieb ,  Yue Zhuo ,  Kurt Bettenhausen

发明人： Shun Jie Fan ,  Hongwei Yang ,  Jun Feng Jiang ,  Herbert Grieb ,  Yue Zhuo ,  Kurt Bettenhausen

IPC分类号： C12Q1/06 ,  C12M1/36

CPC分类号： C12Q1/02 ,  C12M41/46 ,  C12M41/48 ,  C12M43/00 ,  G01N33/5005 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/56966

摘要： A method and device for controlling a fermenting process, wherein the method comprises collecting samples of biological cells from a fermenting tank, obtaining the state information of the current biological cells based on the collected samples, comparing the state information of the current biological cells with preset target status information to obtain the difference between the state information of the current biological cells and preset target state information, and controlling the feed rate of nutritional solution into the fermenting tank. Real time control of biological fermenting process is thus accomplished based on the state information of the biological cells during fermentation, and the consistency during fermentation is improved. Complicated mathematical modeling and man-made data analysis are not required for the method and device. Real time control of biological fermenting process is accomplished based on a feedback loop with simply calculation, and control delay is not created, and automatic control of cells statement in fermentation is achieved.

摘要翻译： 一种用于控制发酵过程的方法和装置，其中所述方法包括从发酵罐收集生物细胞的样品，基于收集的样品获得当前生物细胞的状态信息，将当前生物细胞的状态信息与预设 目标状态信息以获得当前生物细胞的状态信息与预设目标状态信息之间的差异，以及控制营养液进入发酵罐的进料速率。 基于发酵过程中生物细胞的状态信息，实现了生物发酵过程的实时控制，提高了发酵过程中的一致性。 方法和设备不需要复杂的数学建模和人为数据分析。 生物发酵过程的实时控制是通过简单计算的反馈回路实现的，控制延迟不会产生，实现发酵过程中细胞声明的自动控制。