公开(公告)号：US06558957B1

公开(公告)日：2003-05-06

申请号：US09707498

申请日：2000-11-07

申请人： Kurt Roinestad ,  Frank S. Cheng ,  Philip J. Palermo ,  Kevin Bynum

发明人： Kurt Roinestad ,  Frank S. Cheng ,  Philip J. Palermo ,  Kevin Bynum

IPC分类号： G01N2101

CPC分类号： G01N21/33 ,  G01N13/00 ,  G01N21/01 ,  G01N21/05 ,  G01N21/359 ,  G01N21/65 ,  G01N21/8507 ,  G01N33/15 ,  G01N2013/006 ,  G01N2021/6484 ,  G01N2021/651 ,  G01N2021/8521 ,  G01N2021/8528 ,  Y10T436/24 ,  Y10T436/25875

摘要： The present invention relates to an improvement in a detection system used for continuously measuring the release of a drug from a pharmaceutical dosage form comprising a singular dissolution vessel or multiple dissolution vessels containing a dissolution medium and a measuring device for detecting the amount of drug released at a given time, the improvement comprising a mixing shaft and a probe placed within the mixing shaft or outside the individual dissolution vessels, the probe capable of measuring the dissolution characteristics using UV, IR, near-IR, fluorescence, electrochemical, and Raman spectroscopy techniques. The present invention also relates to a method for predicting the dissolution curve provided by a controlled release pharmaceutical dosage form comprising taking continuous measurements of the amount of drug released from a dosage form for a portion of the time over which the drug is expected to be released and predicting the remainder of the dissolution curve based on the values obtained.

摘要翻译： 本发明涉及一种检测系统的改进，所述检测系统用于连续地测量药物从包含溶解介质的单一溶出容器或多个溶解容器的药物剂型中释放的检测系统，所述检测系统包括用于检测药物释放量的测量装置 在一定时间内，改进包括混合轴和放置在混合轴内或各个溶解容器外部的探针，该探针能够使用UV，IR，近红外，荧光，电化学和拉曼光谱技术测量溶解特性 。 本发明还涉及一种用于预测由控释药物剂型提供的溶出曲线的方法，包括连续测量药物预期释放的一段时间内从剂型中释放的药物的量 并基于获得的值预测溶出曲线的剩余部分。

公开(公告)号：US06174497B1

公开(公告)日：2001-01-16

申请号：US08915785

申请日：1997-08-21

申请人： Kurt Roinestad ,  Frank S. Cheng ,  Philip J. Palermo ,  Kevin Bynum

发明人： Kurt Roinestad ,  Frank S. Cheng ,  Philip J. Palermo ,  Kevin Bynum

IPC分类号： G01N2101

CPC分类号： G01N21/33 ,  G01N13/00 ,  G01N21/01 ,  G01N21/05 ,  G01N21/359 ,  G01N21/65 ,  G01N21/8507 ,  G01N33/15 ,  G01N2013/006 ,  G01N2021/6484 ,  G01N2021/651 ,  G01N2021/8521 ,  G01N2021/8528 ,  Y10T436/24 ,  Y10T436/25875

摘要： The present invention relates to an improvement in a detection system used for continuously measuring the release of a drug from a pharmaceutical dosage form having a singular dissolution vessel or multiple dissolution vessels containing a dissolution medium and a measuring device for detecting the amount of drug released at a given time, the improvement being a mixing shaft and a probe placed within the mixing shaft or outside the individual dissolution vessels, the probe capable of measuring the dissolution characteristics using UV, IR, near-IR, fluorescence, electrochemical, and Raman spectroscopy techniques. The present invention also relates to a method for predicting the dissolution curve provided by a controlled release pharmaceutical dosage form by taking continuous measurements of the amount of drug released from a dosage form for a portion of the time over which the drug is expected to be released and predicting the remainder of the dissolution curve based on the values obtained.

摘要翻译： 本发明涉及一种检测系统的改进，该检测系统用于从具有单一溶出容器或含有溶出介质的多个溶解容器的药物剂型连续测量药物的释放，以及用于检测药物释放量的测量装置 给定的时间，改进是混合轴和放置在混合轴内或在各个溶解容器之外的探针，该探针能够使用UV，IR，近红外，荧光，电化学和拉曼光谱技术测量溶解特性 。 本发明还涉及一种用于通过连续测量药物预期释放的一段时间内从剂型中释放的药物的量来预测由控释药物剂型提供的溶出曲线的方法 并基于获得的值预测溶出曲线的剩余部分。