公开(公告)号：US20170067361A1

公开(公告)日：2017-03-09

申请号：US15356815

申请日：2016-11-21

申请人： Kurt Kevin Bynum

发明人： Kurt Kevin Bynum

IPC分类号： F01D21/00 ,  F16B2/10

CPC分类号： F01D21/003 ,  F05D2220/323 ,  F05D2270/804 ,  F16B2/10 ,  F16L19/005 ,  G02B23/2476 ,  Y02T50/671

摘要： A compact, highly-reusable, self-locking includes a body component, a flexible beam finger component with a plurality of axially-oriented flexible beam fingers and one or more outwardly extending tabs, an annular detent ring component including a plurality of detents in radial alignment with the plurality of flexible beam fingers, and a biasing component engaging the flange of the flexible beam finger component and the annular detent ring component for providing a biasing force to urge the flexible finger beam component in a direction of a central, longitudinal axis of the self-locking plug. The flexible beam finger component moves relative to the annular detent ring component when the body component is rotated about the central, longitudinal axis, A, of the self-locking plug, thereby causing the plurality of flexible beam fingers to travel across the plurality of detents and cause elastic deformation of the flexible beam fingers.

摘要翻译： 紧凑的，高度可重复使用的自锁包括主体部件，具有多个轴向定向的柔性梁指的柔性梁指部件和一个或多个向外延伸的突出部，环形棘爪环部件，包括多个径向的棘爪 与多个柔性光束指状物对准，以及偏置部件接合柔性光束指状部件的凸缘和环形棘爪环部件，用于提供偏置力，以在柔性指状部件的中心纵向轴线的方向上推动柔性指形梁部件 自锁插头。 当主体部件围绕自锁塞的中心纵向轴线A旋转时，柔性梁指部件相对于环形棘爪环部件移动，从而导致多个柔性梁指穿过多个棘爪 并引起柔性梁指的弹性变形。

公开(公告)号：US09593700B2

公开(公告)日：2017-03-14

申请号：US14505600

申请日：2014-10-03

申请人： Kurt Kevin Bynum

发明人： Kurt Kevin Bynum

IPC分类号： F16L19/00 ,  H01R13/622 ,  F16B2/10 ,  G02B23/24 ,  F01D21/00

CPC分类号： F16B2/10 ,  F01D21/003 ,  F05D2220/323 ,  F05D2270/804 ,  F16L19/005 ,  G02B23/2476

摘要： A compact, highly-reusable, self-locking includes a body component, a flexible beam finger component with a plurality of axially-oriented flexible beam fingers, a tab sleeve component including one or more downward extending tabs, an annular detent ring component including a plurality of detents in radial alignment with the plurality of flexible beam fingers, and a wave spring disposed between the tab sleeve component and the annular detent ring component for providing a biasing force to urge the tab sleeve component in a direction of a central, longitudinal axis of the self-locking plug. The flexible beam finger component moves relative to the annular detent ring component when the body component is rotated about the central, longitudinal axis, A, of the self-locking plug, thereby causing the plurality of flexible beam fingers to travel across the plurality of detents and cause elastic deformation of the flexible beam fingers.

摘要翻译： 紧凑的，高度可重复使用的自锁包括主体部件，具有多个轴向定向的柔性梁指的柔性梁指部件，包括一个或多个向下延伸的突片的突出部分套筒部件，包括 多个棘爪与多个柔性光束指状件径向对准，以及波形弹簧，设置在突片套筒部件和环形棘爪环部件之间，用于提供偏压力，以在中心纵向轴线的方向上推动突片套筒部件 的自锁插头。 当主体部件围绕自锁塞的中心纵向轴线A旋转时，柔性梁指部件相对于环形棘爪环部件移动，从而导致多个柔性梁指穿过多个棘爪 并引起柔性梁指的弹性变形。

公开(公告)号：US09909446B2

公开(公告)日：2018-03-06

申请号：US15356815

申请日：2016-11-21

申请人： Kurt Kevin Bynum

发明人： Kurt Kevin Bynum

IPC分类号： F01D21/00 ,  F16L19/00 ,  F16B2/10 ,  G02B23/24

CPC分类号： F01D21/003 ,  F05D2220/323 ,  F05D2270/804 ,  F16B2/10 ,  F16L19/005 ,  G02B23/2476 ,  Y02T50/671

摘要： A compact, highly-reusable, self-locking includes a body component, a flexible beam finger component with a plurality of axially-oriented flexible beam fingers and one or more outwardly extending tabs, an annular detent ring component including a plurality of detents in radial alignment with the plurality of flexible beam fingers, and a biasing component engaging the flange of the flexible beam finger component and the annular detent ring component for providing a biasing force to urge the flexible finger beam component in a direction of a central, longitudinal axis of the self-locking plug. The flexible beam finger component moves relative to the annular detent ring component when the body component is rotated about the central, longitudinal axis, A, of the self-locking plug, thereby causing the plurality of flexible beam fingers to travel across the plurality of detents and cause elastic deformation of the flexible beam fingers.

公开(公告)号：US08882384B2

公开(公告)日：2014-11-11

申请号：US13080008

申请日：2011-04-05

申请人： Kurt Kevin Bynum

发明人： Kurt Kevin Bynum

IPC分类号： B25G3/00 ,  B25B23/14 ,  B25B23/142 ,  F16B39/28

CPC分类号： B25B23/141 ,  B25B23/1427 ,  F16B39/28 ,  Y10T403/7005 ,  Y10T403/7011 ,  Y10T408/70

摘要： A compact, highly-reusable, locking device includes a carrier, roller elements, a body, and a band spring. The carrier includes a plurality of apertures for receiving each a corresponding roller element. The body includes a plurality of detents separated by ridges. The number of detents is different than the number of roller elements. The body is at least partially received in the carrier such that the detents are in radial alignment with the apertures. The band spring is disposed about the roller elements. The roller elements travel across the detents and ridges to cause elastic deformation of the band spring when the body is rotated about a central axis.

摘要翻译： 紧凑的，高度可重复使用的锁定装置包括载体，滚子元件，主体和带弹簧。 载体包括多个孔，用于接收每个相应的辊元件。 主体包括多个由脊分开的棘爪。 制动器的数量与滚子元件的数量不同。 主体至少部分地容纳在托架中，使得棘爪与孔径向对准。 带弹簧围绕滚子元件设置。 当主体围绕中心轴线旋转时，滚子元件穿过棘爪和脊部，以引起带弹簧的弹性变形。

公开(公告)号：US20110255914A1

公开(公告)日：2011-10-20

申请号：US13080008

申请日：2011-04-05

申请人： Kurt Kevin Bynum

发明人： Kurt Kevin Bynum

IPC分类号： F16B21/02

CPC分类号： B25B23/141 ,  B25B23/1427 ,  F16B39/28 ,  Y10T403/7005 ,  Y10T403/7011 ,  Y10T408/70

摘要： A compact, highly-reusable, locking device includes a carrier, roller elements, a body, and a band spring. The carrier includes a plurality of apertures for receiving each a corresponding roller element. The body includes a plurality of detents separated by ridges. The number of detents is different than the number of roller elements. The body is at least partially received in the carrier such that the detents are in radial alignment with the apertures. The band spring is disposed about the roller elements. The roller elements travel across the detents and ridges to cause elastic deformation of the band spring when the body is rotated about a central axis.

摘要翻译： 紧凑，高度可重复使用的锁定装置包括载体，滚子元件，主体和带弹簧。 载体包括多个孔，用于接收每个相应的辊元件。 主体包括多个由脊分开的棘爪。 制动器的数量与滚子元件的数量不同。 主体至少部分地容纳在托架中，使得棘爪与孔径向对准。 带弹簧围绕滚子元件设置。 当主体围绕中心轴线旋转时，滚子元件穿过棘爪和脊部，以引起带弹簧的弹性变形。

公开(公告)号：US20050033127A1

公开(公告)日：2005-02-10

申请号：US10766640

申请日：2004-01-27

申请人： Emil Ciurczak ,  Gary Ritchie ,  Howard Mark ,  Kevin Bynum

发明人： Emil Ciurczak ,  Gary Ritchie ,  Howard Mark ,  Kevin Bynum

IPC分类号： A61B5/00 ,  A61K20060101

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B2560/0223

摘要： A system for predicting blood glucose values in a patient includes a remote wireless non-invasive spectral device, the remote wireless non-invasive spectral device generating a spectral scan of a body part of the patient. Also included are a remote invasive device and a central processing device. The remote invasive device generates a constituent value for the patient, while the central processing device predicts a blood glucose value for the patient based upon the spectral scan and the constituent value.

摘要翻译： 用于预测患者血糖值的系统包括远程无线非侵入性光谱设备，所述远程无线非侵入光谱设备产生患者身体部位的光谱扫描。 还包括远程侵入性装置和中央处理装置。 远程侵入性装置生成患者的构成值，而中央处理装置基于光谱扫描和构成值预测患者的血糖值。

公开(公告)号：US06174497B1

公开(公告)日：2001-01-16

申请号：US08915785

申请日：1997-08-21

申请人： Kurt Roinestad ,  Frank S. Cheng ,  Philip J. Palermo ,  Kevin Bynum

发明人： Kurt Roinestad ,  Frank S. Cheng ,  Philip J. Palermo ,  Kevin Bynum

IPC分类号： G01N2101

CPC分类号： G01N21/33 ,  G01N13/00 ,  G01N21/01 ,  G01N21/05 ,  G01N21/359 ,  G01N21/65 ,  G01N21/8507 ,  G01N33/15 ,  G01N2013/006 ,  G01N2021/6484 ,  G01N2021/651 ,  G01N2021/8521 ,  G01N2021/8528 ,  Y10T436/24 ,  Y10T436/25875

摘要： The present invention relates to an improvement in a detection system used for continuously measuring the release of a drug from a pharmaceutical dosage form having a singular dissolution vessel or multiple dissolution vessels containing a dissolution medium and a measuring device for detecting the amount of drug released at a given time, the improvement being a mixing shaft and a probe placed within the mixing shaft or outside the individual dissolution vessels, the probe capable of measuring the dissolution characteristics using UV, IR, near-IR, fluorescence, electrochemical, and Raman spectroscopy techniques. The present invention also relates to a method for predicting the dissolution curve provided by a controlled release pharmaceutical dosage form by taking continuous measurements of the amount of drug released from a dosage form for a portion of the time over which the drug is expected to be released and predicting the remainder of the dissolution curve based on the values obtained.

摘要翻译： 本发明涉及一种检测系统的改进，该检测系统用于从具有单一溶出容器或含有溶出介质的多个溶解容器的药物剂型连续测量药物的释放，以及用于检测药物释放量的测量装置 给定的时间，改进是混合轴和放置在混合轴内或在各个溶解容器之外的探针，该探针能够使用UV，IR，近红外，荧光，电化学和拉曼光谱技术测量溶解特性 。 本发明还涉及一种用于通过连续测量药物预期释放的一段时间内从剂型中释放的药物的量来预测由控释药物剂型提供的溶出曲线的方法 并基于获得的值预测溶出曲线的剩余部分。

公开(公告)号：US20160097412A1

公开(公告)日：2016-04-07

申请号：US14505600

申请日：2014-10-03

申请人： Kurt Kevin Bynum

发明人： Kurt Kevin Bynum

IPC分类号： F16B2/10 ,  F01D21/00

CPC分类号： F16B2/10 ,  F01D21/003 ,  F05D2220/323 ,  F05D2270/804 ,  F16L19/005 ,  G02B23/2476

摘要： A compact, highly-reusable, self-locking includes a body component, a flexible beam finger component with a plurality of axially-oriented flexible beam fingers, a tab sleeve component including one or more downward extending tabs, an annular detent ring component including a plurality of detents in radial alignment with the plurality of flexible beam fingers, and a wave spring disposed between the tab sleeve component and the annular detent ring component for providing a biasing force to urge the tab sleeve component in a direction of a central, longitudinal axis of the self-locking plug. The flexible beam finger component moves relative to the annular detent ring component when the body component is rotated about the central, longitudinal axis, A, of the self-locking plug, thereby causing the plurality of flexible beam fingers to travel across the plurality of detents and cause elastic deformation of the flexible beam fingers.

摘要翻译： 紧凑的，高度可重复使用的自锁包括主体部件，具有多个轴向定向的柔性梁指的柔性梁指部件，包括一个或多个向下延伸的突片的突出部分套筒部件，包括 多个棘爪与多个柔性光束指状件径向对准，以及波形弹簧，设置在突片套筒部件和环形棘爪环部件之间，用于提供偏压力，以在中心纵向轴线的方向上推动突片套筒部件 的自锁插头。 当主体部件围绕自锁塞的中心纵向轴线A旋转时，柔性梁指部件相对于环形棘爪环部件移动，从而导致多个柔性梁指穿过多个棘爪 并引起柔性梁指的弹性变形。

公开(公告)号：US06558957B1

公开(公告)日：2003-05-06

申请号：US09707498

申请日：2000-11-07

申请人： Kurt Roinestad ,  Frank S. Cheng ,  Philip J. Palermo ,  Kevin Bynum

发明人： Kurt Roinestad ,  Frank S. Cheng ,  Philip J. Palermo ,  Kevin Bynum

IPC分类号： G01N2101

CPC分类号： G01N21/33 ,  G01N13/00 ,  G01N21/01 ,  G01N21/05 ,  G01N21/359 ,  G01N21/65 ,  G01N21/8507 ,  G01N33/15 ,  G01N2013/006 ,  G01N2021/6484 ,  G01N2021/651 ,  G01N2021/8521 ,  G01N2021/8528 ,  Y10T436/24 ,  Y10T436/25875

摘要： The present invention relates to an improvement in a detection system used for continuously measuring the release of a drug from a pharmaceutical dosage form comprising a singular dissolution vessel or multiple dissolution vessels containing a dissolution medium and a measuring device for detecting the amount of drug released at a given time, the improvement comprising a mixing shaft and a probe placed within the mixing shaft or outside the individual dissolution vessels, the probe capable of measuring the dissolution characteristics using UV, IR, near-IR, fluorescence, electrochemical, and Raman spectroscopy techniques. The present invention also relates to a method for predicting the dissolution curve provided by a controlled release pharmaceutical dosage form comprising taking continuous measurements of the amount of drug released from a dosage form for a portion of the time over which the drug is expected to be released and predicting the remainder of the dissolution curve based on the values obtained.

摘要翻译： 本发明涉及一种检测系统的改进，所述检测系统用于连续地测量药物从包含溶解介质的单一溶出容器或多个溶解容器的药物剂型中释放的检测系统，所述检测系统包括用于检测药物释放量的测量装置 在一定时间内，改进包括混合轴和放置在混合轴内或各个溶解容器外部的探针，该探针能够使用UV，IR，近红外，荧光，电化学和拉曼光谱技术测量溶解特性 。 本发明还涉及一种用于预测由控释药物剂型提供的溶出曲线的方法，包括连续测量药物预期释放的一段时间内从剂型中释放的药物的量 并基于获得的值预测溶出曲线的剩余部分。