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1.发明授权公开(公告)号：US07314880B2
公开(公告)日：2008-01-01
申请号：US10749437
申请日：2003-12-31
申请人： Kwen-Jen Chang , William Pendergast , Peter J. Gengo , Xin Ma
发明人： Kwen-Jen Chang , William Pendergast , Peter J. Gengo , Xin Ma
IPC分类号： A61K31/495 , A61K31/517 , A61K31/496
CPC分类号： A61K45/06 , A61K31/395 , A61K31/495 , A61K31/50 , A61K2300/00
摘要： The present invention relates to compositions and methods of treatment for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective effects of ischemic preconditioning. The compounds are used to reduce injury associated with ischemia and reperfusion of cardiac tissue. Further, the compounds may be used in solutions preserving the viability of an isolated organ.
摘要翻译： 本发明涉及通过使用介导缺血预处理的心脏保护作用的非肽Δ阿片受体激动剂化合物来治疗心脏保护的组合物和方法。 该化合物用于减少与心脏组织的缺血和再灌注相关的损伤。 此外，化合物可以用于保持分离的器官的活力的溶液中。
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2.发明授权Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists 有权用Δ阿片受体激动剂对抗下尿路功能障碍的组合物和方法公开(公告)号：US08476280B2
公开(公告)日：2013-07-02
申请号：US10434004
申请日：2003-05-08
申请人： Kwen-Jen Chang , Peter J. Gengo , Kestutis P. Biciunas , Xin Ma , William Pendergast , Shyi-Tai Jan
发明人： Kwen-Jen Chang , Peter J. Gengo , Kestutis P. Biciunas , Xin Ma , William Pendergast , Shyi-Tai Jan
IPC分类号： A61K31/4965 , A61K31/497
CPC分类号： A61K31/496 , A61K31/495 , A61K45/06
摘要： Compositions and methods for treatment of a urinary tract dysfunction by administering to a subject in need of such treatment a pharmaceutical composition including a delta opioid receptor agonist in an amount effective to reduce the effects of the urinary tract dysfunction. The compositions may further include an additional active agent that is used to treat urinary tract dysfunctions, e.g., alpha-adrenergic agonists, anticholinergics, alpha-adrenergic antagonists and tricyclic antidepressants.
摘要翻译： 用于治疗尿道功能障碍的组合物和方法，其通过向需要这种治疗的受试者施用包含δ阿片受体激动剂的药物组合物，其量有效降低尿路功能障碍的作用。 组合物还可以包括用于治疗尿道功能障碍的另外的活性剂，例如α-肾上腺素能激动剂，抗胆碱能药，α-肾上腺素能拮抗剂和三环抗抑郁药。
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3.发明申请CARDIOPROTECTIVE DELTA OPIOID RECEPTOR AGONISTS AND METHODS OF USING SAME 审中-公开心脏保护性三磷酸酯受体激动剂及其使用方法公开(公告)号：US20080125443A1
公开(公告)日：2008-05-29
申请号：US11945815
申请日：2007-11-27
申请人： Kwen-Jen Chang , William Pendergast , Peter J. Gengo , Xin Ma
发明人： Kwen-Jen Chang , William Pendergast , Peter J. Gengo , Xin Ma
IPC分类号： A61K31/495
CPC分类号： A61K45/06 , A61K31/395 , A61K31/495 , A61K31/50 , A61K2300/00
摘要： The present invention relates to compositions and methods of treatment for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective effects of ischemic preconditioning. The compounds are used to reduce injury associated with ischemia and reperfusion of cardiac tissue. Further, the compounds may be used in solutions preserving the viability of an isolated organ.
摘要翻译： 本发明涉及通过使用介导缺血预处理的心脏保护作用的非肽Δ阿片受体激动剂化合物来治疗心脏保护的组合物和方法。 该化合物用于减少与心脏组织的缺血和再灌注相关的损伤。 此外，化合物可以用于保持分离的器官的活力的溶液中。
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公开(公告)号：US07030124B2
公开(公告)日：2006-04-18
申请号：US10282411
申请日：2002-10-29
IPC分类号： A61K31/495 , A61K31/496
CPC分类号： A61K31/497
摘要： Methods for treatment of depression or other affective mood disorders, such as bipolar manic depression or seasonal affective disorder, are disclosed by administration to a subject suffering or susceptible to same, of therapeutically effective diarylpiperazine compounds as herein described.
摘要翻译： 用于治疗抑郁症或其他情绪性情绪障碍（例如双相躁狂抑郁症或季节性情感障碍）的方法通过施用给患有或易受相同治疗有效的二芳基哌嗪化合物的受试者公开，如本文所述。
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5.发明申请METHOD OF TREATING PARKINSON'S DISEASE WITH DIARYLMETHYLPIPERAZINE COMPOUNDS EXHIBITING DELTA RECEPTOR AGONIST ACTIVITY 有权二胺嘧啶化合物治疗帕金森病的方法展示DELTA受体激动剂活性公开(公告)号：US20070066625A1
公开(公告)日：2007-03-22
申请号：US11470012
申请日：2006-09-05
IPC分类号： A61K31/495
CPC分类号： A61K31/495 , A61K9/7023 , A61K31/496 , A61K45/06 , C07D241/04 , A61K2300/00
摘要： Compositions and methods for treatment of Parkinson's disease to reduce the negative side effects of the disease by administering a therapeutically effective diarylmethylpiperazine compound which exhibits delta opioid receptor agonist activity, and optionally, mu receptor antagonist activity.
摘要翻译： 用于治疗帕金森病的组合物和方法，通过施用具有δ阿片受体激动剂活性的治疗有效的二芳基甲基哌嗪化合物和任选的mu受体拮抗剂活性来减少疾病的负面副作用。
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6.发明授权Method of treating Parkinson's Disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity 有权用表现出δ受体激动剂活性的二芳基甲基哌嗪化合物治疗帕金森病的方法公开(公告)号：US08642599B2
公开(公告)日：2014-02-04
申请号：US11470012
申请日：2006-09-05
IPC分类号： A61K31/497
CPC分类号： A61K31/495 , A61K9/7023 , A61K31/496 , A61K45/06 , C07D241/04 , A61K2300/00
摘要： Compositions and methods for treatment of Parkinson's disease to reduce the negative side effects of the disease by administering a therapeutically effective diarylmethylpiperazine compound which exhibits delta opioid receptor agonist activity, and optionally, mu receptor antagonist activity.
摘要翻译： 用于治疗帕金森病的组合物和方法，通过施用具有δ阿片受体激动剂活性的治疗有效的二芳基甲基哌嗪化合物和任选的mu受体拮抗剂活性来减少疾病的负面副作用。
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公开(公告)号：US09701645B2
公开(公告)日：2017-07-11
申请号：US14170791
申请日：2014-02-03
IPC分类号： A61K31/497 , C07D241/04 , A61K31/495 , A61K31/496 , A61K45/06
CPC分类号： A61K31/495 , A61K9/7023 , A61K31/496 , A61K45/06 , C07D241/04 , A61K2300/00
摘要： Compositions and methods for treatment of Parkinson's disease to reduce the negative side effects of the disease by administering a therapeutically effective diarylmethylpiperazine compound which exhibits delta opioid receptor agonist activity, and optionally, mu receptor antagonist activity.
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公开(公告)号：US20070173515A1
公开(公告)日：2007-07-26
申请号：US11696806
申请日：2007-04-05
申请人： Kwen-Jen Chang , Klim King , Kestutis Biciunas , Robert McNutt , William Pendergast , Shyi-Tai Jan
发明人： Kwen-Jen Chang , Klim King , Kestutis Biciunas , Robert McNutt , William Pendergast , Shyi-Tai Jan
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D241/04 , A61K31/00 , A61K31/445 , A61K31/495 , A61K31/519 , A61K38/33 , A61K2300/00
摘要： Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
摘要翻译： 用于治疗性功能障碍的组合物和方法，其通过向受试者施用包含δ阿片受体激动剂的药物组合物，所述药物组合物有效地延迟性刺激期间受试者的射精发作。
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公开(公告)号：US08575169B2
公开(公告)日：2013-11-05
申请号：US10335764
申请日：2003-01-02
申请人： Kwen-Jen Chang , Klim King , Kestutis P. Biciunas , Robert W. McNutt, Jr. , William Pendergast , Shyi-Tai Jan
发明人： Kwen-Jen Chang , Klim King , Kestutis P. Biciunas , Robert W. McNutt, Jr. , William Pendergast , Shyi-Tai Jan
IPC分类号： A61K31/497
CPC分类号： C07D241/04 , A61K31/00 , A61K31/445 , A61K31/495 , A61K31/519 , A61K38/33 , A61K2300/00
摘要： Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
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公开(公告)号：US08551998B2
公开(公告)日：2013-10-08
申请号：US13439948
申请日：2012-04-05
申请人： Kwen-Jen Chang , Klim King , Kestutis P. Biciunas , Robert W. McNutt, Jr. , William Pendergast , Shy-Tai Jan
发明人： Kwen-Jen Chang , Klim King , Kestutis P. Biciunas , Robert W. McNutt, Jr. , William Pendergast , Shy-Tai Jan
IPC分类号： A61K31/497
CPC分类号： C07D241/04 , A61K31/00 , A61K31/445 , A61K31/495 , A61K31/519 , A61K38/33 , A61K2300/00
摘要： Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
摘要翻译： 用于治疗性功能障碍的组合物和方法，其通过向受试者施用包含δ阿片受体激动剂的药物组合物，所述药物组合物有效地延迟性刺激期间受试者的射精发作。
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