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    Compositions of novel opioid compounds and method of use thereof
    4.
    发明授权
    Compositions of novel opioid compounds and method of use thereof 有权
    新型阿片类化合物的组合物及其使用方法

    公开(公告)号：US07683168B2

    公开(公告)日：2010-03-23

    申请号：US11404632

    申请日：2006-04-14

    申请人： Shyi-Tai Jan ,  Kwen-Jen Chang ,  Kestutis P. Biciunas ,  Xin Ma

    发明人： Shyi-Tai Jan ,  Kwen-Jen Chang ,  Kestutis P. Biciunas ,  Xin Ma

    IPC分类号： C07D245/02

    CPC分类号： C07D405/12 ,  C07D241/04 ,  C07D401/10 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D491/10

    摘要： Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastro-intestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.

    摘要翻译： 描述了二芳基甲基哌嗪化合物，其可用作mu和/或δ受体阿片样物质，没有中枢副作用。 包含这些化合物的药物组合物可用于外周或非中枢介导的适应症，包括周围介导的和神经性疼痛，泌尿生殖道疾病，膀胱过度活动症，尿失禁，性功能障碍，早泄，咳嗽，肺水肿，心脏病，心脏保护， 胃肠道疾病，腹泻，肠易激综合征，功能扩张，免疫调节和抗肿瘤活性。

    CARDIOPROTECTIVE DELTA OPIOID RECEPTOR AGONISTS AND METHODS OF USING SAME
    6.
    发明申请
    CARDIOPROTECTIVE DELTA OPIOID RECEPTOR AGONISTS AND METHODS OF USING SAME 审中-公开
    心脏保护性三磷酸酯受体激动剂及其使用方法

    公开(公告)号：US20080125443A1

    公开(公告)日：2008-05-29

    申请号：US11945815

    申请日：2007-11-27

    申请人： Kwen-Jen Chang ,  William Pendergast ,  Peter J. Gengo ,  Xin Ma

    发明人： Kwen-Jen Chang ,  William Pendergast ,  Peter J. Gengo ,  Xin Ma

    IPC分类号： A61K31/495

    CPC分类号： A61K45/06 ,  A61K31/395 ,  A61K31/495 ,  A61K31/50 ,  A61K2300/00

    摘要： The present invention relates to compositions and methods of treatment for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective effects of ischemic preconditioning. The compounds are used to reduce injury associated with ischemia and reperfusion of cardiac tissue. Further, the compounds may be used in solutions preserving the viability of an isolated organ.

    摘要翻译： 本发明涉及通过使用介导缺血预处理的心脏保护作用的非肽Δ阿片受体激动剂化合物来治疗心脏保护的组合物和方法。 该化合物用于减少与心脏组织的缺血和再灌注相关的损伤。 此外，化合物可以用于保持分离的器官的活力的溶液中。

    Compositions of novel opioid compounds and method of use thereof
    9.
    发明申请
    Compositions of novel opioid compounds and method of use thereof 有权
    新型阿片类化合物的组合物及其使用方法

    公开(公告)号：US20070043028A1

    公开(公告)日：2007-02-22

    申请号：US11404632

    申请日：2006-04-14

    申请人： Shyi-Tai Jan ,  Kwen-Jen Chang ,  Kestutis Biciunas ,  Xin Ma

    发明人： Shyi-Tai Jan ,  Kwen-Jen Chang ,  Kestutis Biciunas ,  Xin Ma

    IPC分类号： A61K31/551 ,  A61K31/497 ,  A61K31/496 ,  A61K31/495 ,  C07D403/02

    CPC分类号： C07D405/12 ,  C07D241/04 ,  C07D401/10 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D491/10

    摘要： Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastrointestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.

    摘要翻译： 描述了二芳基甲基哌嗪化合物，其可用作mu和/或δ受体阿片样物质，没有中枢副作用。 包含这些化合物的药物组合物可用于外周或非中枢介导的适应症，包括周围介导的和神经性疼痛，泌尿生殖道疾病，膀胱过度活动症，尿失禁，性功能障碍，早泄，咳嗽，肺水肿，心脏病，心脏保护， 胃肠道疾病，腹泻，肠易激综合征，功能扩张，免疫调节和抗肿瘤活性。