公开(公告)号：US20170369850A1

公开(公告)日：2017-12-28

申请号：US15326977

申请日：2015-07-17

申请人： Kyoto University ,  Thyas Co. Ltd.

发明人： Shin Kaneko ,  Hiroshi Kawamoto ,  Kyoko Masuda ,  Atsutaka Minagawa ,  Akitsu Hotta ,  Yutaka Shimazu ,  Hiroshi Ichise

IPC分类号： C12N5/074 ,  C12N5/10 ,  A61K35/17

CPC分类号： C12N5/0696 ,  A61K35/14 ,  A61K35/17 ,  A61P35/00 ,  C12N5/10

摘要： Provided is a method for inducing T cells for a cell-based immunotherapy, comprising the steps of: (1) providing Rag 1 and/or Rag 2 gene knockout human pluripotent stem cells bearing genes encoding a T cell receptor specific for a desired antigen, and (2) inducing T cells from the pluripotent stem cells of step (1). Further provided are a cell-based immunotherapy method that uses the T cells for the cell-based immunotherapy and an iPS cell bank for the cell-based immunotherapy.