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公开(公告)号：US20090292117A1
公开(公告)日：2009-11-26
申请号：US12312889
申请日：2007-10-24
申请人： Kyung-ll Kim , Seung-Bum Ha , Jae-Hoon Jeon , Soon-Jeong Kwon , Yong-Tae Kim , Ji-Suk Yun
发明人： Kyung-ll Kim , Seung-Bum Ha , Jae-Hoon Jeon , Soon-Jeong Kwon , Yong-Tae Kim , Ji-Suk Yun
IPC分类号： C07H3/02
CPC分类号： C07H3/02
摘要： A method of preparing 2-deoxy-L-ribose represented by the following formula I is disclosed. The preparation method includes the steps of: treating L-arabinose with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-L-arabinopyranose; allowing the prepared 1-alkoxy-L-arabinopyranose to react with acyl chloride so as to prepare 1-alkoxy-2,3,4-triacyl-L-arabinopyranose; brominating the alkoxy group of the prepared 1-alkoxy-2,3,4-triacyl-L-arabinopyranose to prepare a 1-bromo-2,3,4-triacyl compound; allowing the prepared compound to react with zinc in the presence of ethyl acetate and an organic base so as to prepare glycal; treating the glycal with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose; treating the prepared 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose with a base to prepare 1-alkoxy-2-deoxy-L-ribopyranose; and hydrolyzing the prepared 1-alkoxy-2-deoxy-L-ribopyranose in the presence of an acid catalyst.
摘要翻译： 公开了制备由下式I表示的2-脱氧-L-核糖的方法。 该制备方法包括以下步骤：在酸存在下用醇溶剂处理L-阿拉伯糖以制备1-烷氧基-L-阿拉伯吡喃糖; 使制备的1-烷氧基-L-阿拉伯吡喃与酰氯反应，制得1-烷氧基-2,3,4-三酰基-L-阿拉伯吡喃糖; 溴化制备的1-烷氧基-2,3,4-三酰基-L-阿拉伯吡喃糖的烷氧基以制备1-溴-2,3,4-三酰基化合物; 使得制备的化合物在乙酸乙酯和有机碱的存在下与锌反应，以制备甘氨酸; 在酸的存在下用醇溶剂处理甘氨酸以制备1-烷氧基-2-脱氧-3,4-二酰基-L-吡喃糖; 用碱处理制备的1-烷氧基-2-脱氧-3,4-二酰基-L-吡喃糖，制备1-烷氧基-2-脱氧-L-吡喃糖; 并在酸催化剂存在下水解制备的1-烷氧基-2-脱氧-L-吡喃糖。
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公开(公告)号：US08114987B2
公开(公告)日：2012-02-14
申请号：US12312889
申请日：2007-10-24
申请人： Kyung-Il Kim , Seung-Bum Ha , Jae-Hoon Jeon , Soon-Jeong Kwon , Yong-Tae Kim , Ji-Suk Yun
发明人： Kyung-Il Kim , Seung-Bum Ha , Jae-Hoon Jeon , Soon-Jeong Kwon , Yong-Tae Kim , Ji-Suk Yun
CPC分类号： C07H3/02
摘要： A method of preparing 2-deoxy-L-ribose represented by the following formula I is disclosed. The preparation method includes the steps of: treating L-arabinose with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-L-arabinopyranose; allowing the prepared 1-alkoxy-L-arabinopyranose to react with acyl chloride so as to prepare 1-alkoxy-2,3,4-triacyl-L-arabinopyranose; brominating the alkoxy group of the prepared 1-alkoxy-2,3,4-triacyl-L-arabinopyranose to prepare a 1-bromo-2,3,4-triacyl compound; allowing the prepared compound to react with zinc in the presence of ethyl acetate and an organic base so as to prepare glycal; treating the glycal with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose; treating the prepared 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose with a base to prepare 1-alkoxy-2-deoxy-L-ribopyranose; and hydrolyzing the prepared 1-alkoxy-2-deoxy-L-ribopyranose in the presence of an acid catalyst.
摘要翻译： 公开了制备由下式I表示的2-脱氧-L-核糖的方法。 该制备方法包括以下步骤：在酸存在下用醇溶剂处理L-阿拉伯糖以制备1-烷氧基-L-阿拉伯吡喃糖; 使制备的1-烷氧基-L-阿拉伯吡喃与酰氯反应，制得1-烷氧基-2,3,4-三酰基-L-阿拉伯吡喃糖; 溴化制备的1-烷氧基-2,3,4-三酰基-L-阿拉伯吡喃糖的烷氧基以制备1-溴-2,3,4-三酰基化合物; 使得制备的化合物在乙酸乙酯和有机碱的存在下与锌反应，以制备甘氨酸; 在酸的存在下用醇溶剂处理甘氨酸以制备1-烷氧基-2-脱氧-3,4-二酰基-L-吡喃糖; 用碱处理制备的1-烷氧基-2-脱氧-3,4-二酰基-L-吡喃糖，制备1-烷氧基-2-脱氧-L-吡喃糖; 并在酸催化剂存在下水解制备的1-烷氧基-2-脱氧-L-吡喃糖。
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