公开(公告)号：US08837651B2

公开(公告)日：2014-09-16

申请号：US11844243

申请日：2007-08-23

申请人： Jae-Hoon Jeon

发明人： Jae-Hoon Jeon

IPC分类号： H04B1/10 ,  H04L25/02 ,  H04L25/03 ,  H04L27/26

CPC分类号： H04L25/0232 ,  H04L25/0256 ,  H04L27/2647 ,  H04L2025/03547 ,  H04L2025/03726

摘要： An apparatus and a method for estimating a channel in a broadband wireless access system. A receiving apparatus includes a first channel estimation filter having a tap coefficient which is channel-adaptively variable, the first channel estimation filter acquiring a channel impulse response by filtering received pilot symbols, a second channel estimation filter having a fixed tap coefficient, the second channel estimation filter acquiring a channel impulse response by filtering received pilot symbols, and a selector which selects the operation of one of the first and the second channel estimation filters according to channel correlativity.

摘要翻译： 一种用于估计宽带无线接入系统中的信道的装置和方法。 接收装置包括具有信道自适应变化的抽头系数的第一信道估计滤波器，第一信道估计滤波器通过对接收到的导频符号进行滤波来获取信道脉冲响应，具有固定抽头系数的第二信道估计滤波器，第二信道 估计滤波器通过对接收到的导频符号进行滤波来获取信道脉冲响应;以及选择器，其根据信道相关性选择第一和第二信道估计滤波器之一的操作。

公开(公告)号：US07371859B2

公开(公告)日：2008-05-13

申请号：US11182935

申请日：2005-07-15

申请人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

发明人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

IPC分类号： C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14 ,  C07D239/54 ,  C07D241/18

CPC分类号： C07D417/04 ,  C07B2200/11 ,  C07D277/80 ,  C07D417/12 ,  C07D417/14 ,  Y02P20/55

摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

摘要翻译： 本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地为H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5为H或保护或未保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

公开(公告)号：US20090292117A1

公开(公告)日：2009-11-26

申请号：US12312889

申请日：2007-10-24

申请人： Kyung-ll Kim ,  Seung-Bum Ha ,  Jae-Hoon Jeon ,  Soon-Jeong Kwon ,  Yong-Tae Kim ,  Ji-Suk Yun

发明人： Kyung-ll Kim ,  Seung-Bum Ha ,  Jae-Hoon Jeon ,  Soon-Jeong Kwon ,  Yong-Tae Kim ,  Ji-Suk Yun

IPC分类号： C07H3/02

CPC分类号： C07H3/02

摘要： A method of preparing 2-deoxy-L-ribose represented by the following formula I is disclosed. The preparation method includes the steps of: treating L-arabinose with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-L-arabinopyranose; allowing the prepared 1-alkoxy-L-arabinopyranose to react with acyl chloride so as to prepare 1-alkoxy-2,3,4-triacyl-L-arabinopyranose; brominating the alkoxy group of the prepared 1-alkoxy-2,3,4-triacyl-L-arabinopyranose to prepare a 1-bromo-2,3,4-triacyl compound; allowing the prepared compound to react with zinc in the presence of ethyl acetate and an organic base so as to prepare glycal; treating the glycal with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose; treating the prepared 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose with a base to prepare 1-alkoxy-2-deoxy-L-ribopyranose; and hydrolyzing the prepared 1-alkoxy-2-deoxy-L-ribopyranose in the presence of an acid catalyst.

摘要翻译： 公开了制备由下式I表示的2-脱氧-L-核糖的方法。 该制备方法包括以下步骤：在酸存在下用醇溶剂处理L-阿拉伯糖以制备1-烷氧基-L-阿拉伯吡喃糖; 使制备的1-烷氧基-L-阿拉伯吡喃与酰氯反应，制得1-烷氧基-2,3,4-三酰基-L-阿拉伯吡喃糖; 溴化制备的1-烷氧基-2,3,4-三酰基-L-阿拉伯吡喃糖的烷氧基以制备1-溴-2,3,4-三酰基化合物; 使得制备的化合物在乙酸乙酯和有机碱的存在下与锌反应，以制备甘氨酸; 在酸的存在下用醇溶剂处理甘氨酸以制备1-烷氧基-2-脱氧-3,4-二酰基-L-吡喃糖; 用碱处理制备的1-烷氧基-2-脱氧-3,4-二酰基-L-吡喃糖，制备1-烷氧基-2-脱氧-L-吡喃糖; 并在酸催化剂存在下水解制备的1-烷氧基-2-脱氧-L-吡喃糖。

公开(公告)号：US06969766B2

公开(公告)日：2005-11-29

申请号：US10424181

申请日：2003-04-25

申请人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

发明人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

IPC分类号： C12N15/09 ,  A61K31/513 ,  A61K31/52 ,  C07D277/80 ,  C07D405/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D473/02 ,  C07D473/18 ,  C07D473/32 ,  C07D473/34 ,  C07D247/02 ,  C07D413/12

CPC分类号： C07D417/04 ,  C07B2200/11 ,  C07D277/80 ,  C07D417/12 ,  C07D417/14 ,  Y02P20/55

摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

摘要翻译： 本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地是H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5是H或被保护或未被保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

公开(公告)号：US07125994B2

公开(公告)日：2006-10-24

申请号：US11182672

申请日：2005-07-15

申请人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

发明人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

IPC分类号： C07D473/34 ,  C07D473/18 ,  C07D247/02 ,  C07D417/12 ,  C07D413/12

CPC分类号： C07D417/04 ,  C07B2200/11 ,  C07D277/80 ,  C07D417/12 ,  C07D417/14 ,  Y02P20/55

摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

公开(公告)号：US08114987B2

公开(公告)日：2012-02-14

申请号：US12312889

申请日：2007-10-24

申请人： Kyung-Il Kim ,  Seung-Bum Ha ,  Jae-Hoon Jeon ,  Soon-Jeong Kwon ,  Yong-Tae Kim ,  Ji-Suk Yun

发明人： Kyung-Il Kim ,  Seung-Bum Ha ,  Jae-Hoon Jeon ,  Soon-Jeong Kwon ,  Yong-Tae Kim ,  Ji-Suk Yun

IPC分类号： C07H15/00 ,  C07H17/00 ,  C07H1/00 ,  C07H3/00 ,  C07G3/00 ,  C08B37/00

CPC分类号： C07H3/02

摘要： A method of preparing 2-deoxy-L-ribose represented by the following formula I is disclosed. The preparation method includes the steps of: treating L-arabinose with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-L-arabinopyranose; allowing the prepared 1-alkoxy-L-arabinopyranose to react with acyl chloride so as to prepare 1-alkoxy-2,3,4-triacyl-L-arabinopyranose; brominating the alkoxy group of the prepared 1-alkoxy-2,3,4-triacyl-L-arabinopyranose to prepare a 1-bromo-2,3,4-triacyl compound; allowing the prepared compound to react with zinc in the presence of ethyl acetate and an organic base so as to prepare glycal; treating the glycal with an alcohol solvent in the presence of an acid to prepare 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose; treating the prepared 1-alkoxy-2-deoxy-3,4-diacyl-L-ribopyranose with a base to prepare 1-alkoxy-2-deoxy-L-ribopyranose; and hydrolyzing the prepared 1-alkoxy-2-deoxy-L-ribopyranose in the presence of an acid catalyst.

摘要翻译： 公开了制备由下式I表示的2-脱氧-L-核糖的方法。 该制备方法包括以下步骤：在酸存在下用醇溶剂处理L-阿拉伯糖以制备1-烷氧基-L-阿拉伯吡喃糖; 使制备的1-烷氧基-L-阿拉伯吡喃与酰氯反应，制得1-烷氧基-2,3,4-三酰基-L-阿拉伯吡喃糖; 溴化制备的1-烷氧基-2,3,4-三酰基-L-阿拉伯吡喃糖的烷氧基以制备1-溴-2,3,4-三酰基化合物; 使得制备的化合物在乙酸乙酯和有机碱的存在下与锌反应，以制备甘氨酸; 在酸的存在下用醇溶剂处理甘氨酸以制备1-烷氧基-2-脱氧-3,4-二酰基-L-吡喃糖; 用碱处理制备的1-烷氧基-2-脱氧-3,4-二酰基-L-吡喃糖，制备1-烷氧基-2-脱氧-L-吡喃糖; 并在酸催化剂存在下水解制备的1-烷氧基-2-脱氧-L-吡喃糖。

公开(公告)号：US07179896B2

公开(公告)日：2007-02-20

申请号：US11182936

申请日：2005-07-15

申请人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

发明人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

IPC分类号： C07H21/02 ,  C07H21/04 ,  C07H21/00

CPC分类号： C07D417/04 ,  C07B2200/11 ,  C07D277/80 ,  C07D417/12 ,  C07D417/14 ,  Y02P20/55

摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

摘要翻译： 本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地是H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5是H或被保护或未被保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能由在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

公开(公告)号：US07411065B2

公开(公告)日：2008-08-12

申请号：US11182977

申请日：2005-07-15

申请人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

发明人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

IPC分类号： C07D403/06 ,  C07D239/34 ,  C07D241/18

CPC分类号： C07D417/04 ,  C07B2200/11 ,  C07D277/80 ,  C07D417/12 ,  C07D417/14 ,  Y02P20/55

摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oglimers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

摘要翻译： 本申请涉及用于制备PNA（肽核酸）激发剂的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E是氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地为H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5为H或保护或未保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

公开(公告)号：US07371860B2

公开(公告)日：2008-05-13

申请号：US11183025

申请日：2005-07-15

申请人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

发明人： Sung Kee Kim ,  Hyunil Lee ,  Jong Chan Lim ,  Hoon Choi ,  Jae Hoon Jeon ,  Sang Youl Ahn ,  Sung Hee Lee ,  Won Jun Yoon

IPC分类号： C07D413/06 ,  C07D417/06

CPC分类号： C07D417/04 ,  C07B2200/11 ,  C07D277/80 ,  C07D417/12 ,  C07D417/14 ,  Y02P20/55

摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrite, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

摘要翻译： 本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地为H，卤素，烷基，硝基，亚硝酸根，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5为H或保护或未保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

公开(公告)号：US20080049814A1

公开(公告)日：2008-02-28

申请号：US11844243

申请日：2007-08-23

申请人： Jae-Hoon JEON

发明人： Jae-Hoon JEON

IPC分类号： H04B1/707

CPC分类号： H04L25/0232 ,  H04L25/0256 ,  H04L27/2647 ,  H04L2025/03547 ,  H04L2025/03726

摘要： An apparatus and a method for estimating a channel in a broadband wireless access system. A receiving apparatus includes a first channel estimation filter having a tap coefficient which is channel-adaptively variable, the first channel estimation filter acquiring a channel impulse response by filtering received pilot symbols, a second channel estimation filter having a fixed tap coefficient, the second channel estimation filter acquiring a channel impulse response by filtering received pilot symbols, and a selector which selects the operation of one of the first and the second channel estimation filters according to channel correlativity.

摘要翻译： 一种用于估计宽带无线接入系统中的信道的装置和方法。 接收装置包括具有信道自适应变化的抽头系数的第一信道估计滤波器，第一信道估计滤波器通过对接收到的导频符号进行滤波来获取信道脉冲响应，具有固定抽头系数的第二信道估计滤波器，第二信道 估计滤波器通过对接收到的导频符号进行滤波来获取信道脉冲响应;以及选择器，其根据信道相关性选择第一和第二信道估计滤波器之一的操作。