公开(公告)号：US20210270813A1

公开(公告)日：2021-09-02

申请号：US17255614

申请日：2018-06-28

Applicant: L'OREAL

Inventor： Rodrigo DE VECCHI ,  Lionel BRETON ,  Charbel BOUEZ ,  Vanja DAKIC

IPC: G01N33/50 ,  C12N5/00 ,  C12N5/0793 ,  C12N5/071

Abstract: The present invention relates to a kit comprising a co-culture microdevice containing peripheral sensory neurons (PSN) and human epidermal keratinocytes (HEK) in a cell culture adapted for both cell types. It is also described a method for screening an active compound using the kit according to the present invention, as well as the use thereof for in vitro dmg tests and for producing a cosmetic product for various dermatological applications, such as atopic dermatitis, sensitive skin, photoaging, wound healing and epidermal thickness in aged skin.