利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.018 秒)

    METHODS AND USES OF NUR77 AND NUR77 AGONISTS TO MODULATE MACROPHAGES AND MONOCYTES, AND TREAT INFLAMMATION, INFLAMMATORY DISEASE AND CARDIOVASCULAR DISEASE
    1.
    发明申请
    METHODS AND USES OF NUR77 AND NUR77 AGONISTS TO MODULATE MACROPHAGES AND MONOCYTES, AND TREAT INFLAMMATION, INFLAMMATORY DISEASE AND CARDIOVASCULAR DISEASE 审中-公开
    NUR77和NUR77激动剂调理巨噬细胞和单核细胞的方法和用途，以及治疗炎症，炎症疾病和心血管疾病

    公开(公告)号：US20130108602A1

    公开(公告)日：2013-05-02

    申请号：US13646183

    申请日：2012-10-05

    申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMU

    发明人： Catherine C. Hedrick ,  Klaus Ley ,  Richard Hanna ,  Iftach Shaked

    IPC分类号： A61K38/17 ,  A61K31/404 ,  A61K31/235 ,  A61K35/14

    CPC分类号： A61K38/1783 ,  A61K31/216 ,  A61K31/235 ,  A61K31/404 ,  A61K35/15 ,  A61K38/00 ,  C07K14/70567

    摘要： Methods of decreasing, reducing, inhibiting, suppressing, limiting or controlling an undesirable or aberrant immune response, immune disorder, inflammatory response, or inflammation in a subject; decreasing, reducing, inhibiting, suppressing, limiting or controlling an autoimmune response, disorder or disease in a subject; and decreasing, reducing, inhibiting, suppressing, limiting or controlling an adverse cardiovascular event or cardiovascular disease in a subject, are provided. Methods include, for example, administering a Nur77 polypeptide or subsequence thereof, a Nur77 agonist, or CD14+ CD16+ monocytes or CD14dimCD16+ (CD115+CD11b+GR1− (Ly6C−)) monocytes or macrophages to a subject to decrease, reduce, inhibit, suppress, limit or control the underlying condition or an adverse symptom or pathology of the condition.

    摘要翻译： 降低，减少，抑制，抑制，限制或控制受试者中不良或异常免疫应答，免疫疾病，炎症反应或炎症的方法; 减少，减少，抑制，抑制，限制或控制受试者的自身免疫应答，病症或疾病; 并且提供减少，减少，抑制，抑制，限制或控制受试者中不利的心血管事件或心血管疾病。 方法包括例如将Nur77多肽或其子序列，Nur77激动剂或CD14 + CD16 +单核细胞或CD14dimCD16 +（CD115 + CD11b + GR1-（Ly6C-））单核细胞或巨噬细胞给予受试者以减少，减少，抑制，抑制 ，限制或控制病症的基础状况或不良症状或病态。