公开(公告)号：US20230390355A1

公开(公告)日：2023-12-07

申请号：US18234795

申请日：2023-08-16

Applicant: ALASTIN SKINCARE, INC.

Inventor： Alan David WIDGEROW ,  John A. GARRUTO

IPC: A61K38/06 ,  A61K38/08 ,  A61K38/17 ,  A61Q7/00 ,  A61K38/30 ,  A61K31/519

CPC classification number: A61K38/06 ,  A61K38/08 ,  A61K38/1783 ,  A61Q7/00 ,  A61K38/30 ,  A61K31/519

Abstract: Provided herein are compositions and methods for targeting dermal white adipose tissue for hair follicle stimulation and regeneration.

公开(公告)号：US20180271941A1

公开(公告)日：2018-09-27

申请号：US15818470

申请日：2017-11-20

Applicant: The Schepens Eye Research Institute, Inc.

Inventor： Neena B. Haider

IPC: A61K38/17 ,  C07K14/47 ,  A61K31/13 ,  A61K48/00

CPC classification number: A61K38/1783 ,  A61K31/13 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0083 ,  C07K14/4705 ,  H05K999/99

Abstract: The present invention relates to compositions and methods comprising administering gene modifiers for treating ocular disease.

公开(公告)号：US20130108602A1

公开(公告)日：2013-05-02

申请号：US13646183

申请日：2012-10-05

Applicant: LA JOLLA INSTITUTE FOR ALLERGY AND IMMU

Inventor： Catherine C. Hedrick ,  Klaus Ley ,  Richard Hanna ,  Iftach Shaked

IPC: A61K38/17 ,  A61K31/404 ,  A61K31/235 ,  A61K35/14

CPC classification number: A61K38/1783 ,  A61K31/216 ,  A61K31/235 ,  A61K31/404 ,  A61K35/15 ,  A61K38/00 ,  C07K14/70567

Abstract: Methods of decreasing, reducing, inhibiting, suppressing, limiting or controlling an undesirable or aberrant immune response, immune disorder, inflammatory response, or inflammation in a subject; decreasing, reducing, inhibiting, suppressing, limiting or controlling an autoimmune response, disorder or disease in a subject; and decreasing, reducing, inhibiting, suppressing, limiting or controlling an adverse cardiovascular event or cardiovascular disease in a subject, are provided. Methods include, for example, administering a Nur77 polypeptide or subsequence thereof, a Nur77 agonist, or CD14+ CD16+ monocytes or CD14dimCD16+ (CD115+CD11b+GR1− (Ly6C−)) monocytes or macrophages to a subject to decrease, reduce, inhibit, suppress, limit or control the underlying condition or an adverse symptom or pathology of the condition.

Abstract translation: 降低，减少，抑制，抑制，限制或控制受试者中不良或异常免疫应答，免疫疾病，炎症反应或炎症的方法; 减少，减少，抑制，抑制，限制或控制受试者的自身免疫应答，病症或疾病; 并且提供减少，减少，抑制，抑制，限制或控制受试者中不利的心血管事件或心血管疾病。 方法包括例如将Nur77多肽或其子序列，Nur77激动剂或CD14 + CD16 +单核细胞或CD14dimCD16 +（CD115 + CD11b + GR1-（Ly6C-））单核细胞或巨噬细胞给予受试者以减少，减少，抑制，抑制 ，限制或控制病症的基础状况或不良症状或病态。

公开(公告)号：US20070054961A1

公开(公告)日：2007-03-08

申请号：US11526458

申请日：2006-09-25

Applicant: Malcolm Maden ,  Jonathan Corcoran

Inventor： Malcolm Maden ,  Jonathan Corcoran

IPC: A61K31/203

CPC classification number: A61K31/19 ,  A61K31/192 ,  A61K31/203 ,  A61K31/38 ,  A61K31/381 ,  A61K38/1783 ,  A61K48/00 ,  A61K2300/00

Abstract: Provided is a method of producing neurite outgrowth and/or development using RARβ2 and/or an agonist thereof.

Abstract translation: 提供了使用RARβ2和/或其激动剂产生神经突生长和/或发育的方法。

公开(公告)号：US20050070493A1

公开(公告)日：2005-03-31

申请号：US10837182

申请日：2004-04-30

Applicant: Stephen Fawell ,  Orla Conneely

Inventor： Stephen Fawell ,  Orla Conneely

IPC: C12N15/09 ,  A61K35/76 ,  A61K38/00 ,  A61K38/17 ,  A61K48/00 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  C12N5/08 ,  C12N5/10 ,  C12N7/00 ,  C12N15/864 ,  C12N15/85

CPC classification number: C12N15/86 ,  A61K38/1783 ,  A61K48/00 ,  C12N2750/14143 ,  C12N2830/008

Abstract: The present invention relates to novel methods and compositions for gene therapy. The invention also provides methods for treating diseases or disorders of the central nervous system associated with dopaminergic hypoactivity, disease, injury or chemical lesioning, including Parkinson's disease, manic depression, and schizophrenia.

Abstract translation: 本发明涉及用于基因治疗的新方法和组合物。 本发明还提供用于治疗与多巴胺能反应性，疾病，损伤或化学损伤相关的中枢神经系统疾病或病症的方法，包括帕金森病，躁狂抑郁症和精神分裂症。

公开(公告)号：US20160015783A1

公开(公告)日：2016-01-21

申请号：US14772039

申请日：2014-03-03

Applicant: THE SCHEPENS EYE RESEARCH INSTITUTE, INC.

Inventor： Neena B. Haider

IPC: A61K38/17

CPC classification number: A61K38/1783 ,  A61K31/13 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0083 ,  C07K14/4705

Abstract: The present invention relates to compositions and methods comprising administering gene modifiers for treating ocular disease.

Abstract translation: 本发明涉及包含施用用于治疗眼病的基因修饰剂的组合物和方法。

公开(公告)号：US20150202261A1

公开(公告)日：2015-07-23

申请号：US14363551

申请日：2012-12-07

Applicant: Fundación Sales ,  Consejo Nacional de Investigaciones Científicas y Técnicas

Inventor： Claudia L. Lanari ,  Victoria Wargon ,  Paola Rojas ,  Maria May ,  Gonzalo Sequeira

IPC: A61K38/17 ,  A61K31/165 ,  A61K31/706 ,  A61K31/567 ,  A61K45/06

CPC classification number: A61K38/1783 ,  A61K31/165 ,  A61K31/567 ,  A61K31/575 ,  A61K31/706 ,  A61K31/7068 ,  A61K45/06 ,  A61K48/005 ,  A61K2300/00

Abstract: The invention provides methods, pharmaceutical compositions and kits for treating a subject having a carcinoma that is resistant to an antiprogestin. In particular, the methods comprise increasing the molar amount of progesterone receptor isoform A (PR-A) so that it is greater than that of isoform B (PR-B) and administering a therapeutically effective amount of an antiprogestin to the subject, thereby treating the carcinoma.

Abstract translation: 本发明提供了用于治疗患有对抗孕激素有抗性的癌症的受试者的方法，药物组合物和试剂盒。 特别地，所述方法包括增加孕酮受体同种型A（PR-A）的摩尔量，使其大于同种型B（PR-B）的摩尔量，并向受试者施用治疗有效量的抗孕激素，从而治疗 癌。

公开(公告)号：US20100317109A1

公开(公告)日：2010-12-16

申请号：US12570659

申请日：2009-09-30

Applicant: Malcolm MADEN ,  Jonathan P.T. Corcoran

Inventor： Malcolm MADEN ,  Jonathan P.T. Corcoran

IPC: C12N5/079

CPC classification number: A61K31/19 ,  A61K31/192 ,  A61K31/203 ,  A61K31/38 ,  A61K31/381 ,  A61K38/1783 ,  A61K48/00 ,  A61K2300/00

Abstract: Provided is a method of producing neurite outgrowth and/or development using RARβ2 and/or an agonist thereof.

Abstract translation: 本发明提供使用RAR＆amp; 2和/或其激动剂产生神经突生长和/或发育的方法。

公开(公告)号：US20090305980A1

公开(公告)日：2009-12-10

申请号：US12300077

申请日：2007-05-09

Applicant: Yi-Fen Lee ,  Chawnshang Chang

Inventor： Yi-Fen Lee ,  Chawnshang Chang

IPC: A61K38/17 ,  C12Q1/68 ,  C12N15/63 ,  C12N5/10 ,  A61P43/00

CPC classification number: G01N33/57434 ,  A61K31/355 ,  A61K31/713 ,  A61K38/1783 ,  A61K45/06 ,  G01N33/5011 ,  G01N33/57496 ,  G01N2333/723 ,  G01N2500/10 ,  G01N2800/105 ,  A61K2300/00

Abstract: Disclosed are compositions and methods related to TR4 and cancer.

Abstract translation: 公开了与TR4和癌相关的组合物和方法。

公开(公告)号：US20040110707A1

公开(公告)日：2004-06-10

申请号：US10468244

申请日：2004-01-20

Inventor： Malcom Maden ,  Jonathan Patrick Thomas Corcoran

IPC: A61K048/00

CPC classification number: A61K38/44 ,  A61K38/1709 ,  A61K38/1783 ,  A61K48/00 ,  C12Y102/01036

Abstract: The invention relates to a method of treating a condition in a subject comprising administering an effective amount of an agent to said subject wherein said agent modulates one or more components of the retinoid signaling pathway.

Abstract translation: 本发明涉及一种治疗受试者的病症的方法，包括向所述受试者施用有效量的试剂，其中所述试剂调节类视黄醇信号通路的一种或多种组分。