专利检索 ap:("LABORATORIO CHIMICO INTERNAZIONALE S.P.A.") AND inv:"Corrado Colli" 第 1 页

1.

发明授权
Process for the preparation of indanamine derivatives and new synthesis intermediates 有权

公开(公告)号：US10059653B2

公开(公告)日：2018-08-28

申请号：US15541931

申请日：2016-01-19

申请人： LABORATORIO CHIMICO INTERNAZIONALE S.P.A.

发明人： Giorgio Bertolini , Paolangelo Cerea , Corrado Colli , Lazzaro Feliciani , Federico Gassa , Aldo Bianchi , Federica Colombo , Stefano Maiorana , Filippo Nisic

IPC分类号： C07C209/22 , C07C67/00 , C07C45/46 , C07C29/00 , C07C303/28 , C07C69/14 , C07C69/78 , C07C35/32 , C07C309/73 , C07C309/66 , C07C49/84

CPC分类号： C07C209/22 , C07C29/00 , C07C35/32 , C07C43/188 , C07C45/46 , C07C49/84 , C07C67/00 , C07C69/14 , C07C69/157 , C07C69/78 , C07C209/14 , C07C303/28 , C07C309/66 , C07C309/73 , C07C2602/08 , C07C211/42

摘要： Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates. Formula (I):

2.

发明授权
Method for the preparation of 1-(2-halogen-ethyl)-4 piperidine-carboxylic acid ethyl esters 有权

公开(公告)号：US10023535B2

公开(公告)日：2018-07-17

申请号：US15520256

申请日：2015-10-22

申请人： LABORATORIO CHIMICO INTERNAZIONALE S.P.A.

发明人： Giorgio Bertolini , Corrado Colli , Aldo Bianchi , Federica Colombo , Stefano Maiorana , Filippo Nisic

IPC分类号： C07D211/62 , C07C22/00 , C07F13/00 , C07D211/06 , C07C209/24

摘要： The present invention refers to a process for the preparation of 1-(2-halogen-ethyl)-4-piperidinecarboxylic acid ethyl esters, in particular of 1-(2-chloroethyl)-4 piperidinecarboxylic acid ethyl ester, a versatile synthesis intermediate, particularly useful as an intermediate compound in the synthesis of umeclidinium.