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公开(公告)号：US09709577B2
公开(公告)日：2017-07-18
申请号：US14386940
申请日：2013-03-22
申请人： LABORATORIOS DEL DR. ESTEVE S.A. , FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
IPC分类号： G01N33/68 , G01N33/50 , G01N33/569
CPC分类号： G01N33/6866 , G01N33/505 , G01N33/5091 , G01N33/56988 , G01N2333/15 , G01N2333/52 , G01N2333/525 , G01N2333/54 , G01N2333/555 , G01N2800/52 , G01N2800/56 , G01N2800/60
摘要： The invention relates to a method and a diagnostic kit for monitoring HIV specific T cell responses and identifying subjects capable of controlling HIV progression or preventing HIV infection altogether. The method is based on the combined use of boosted flow cytometry and toggle peptides and can cover a large set of effector functions. The method is also suitable to detect T cell responses of any desirable cytokine or combination of cytokines to any pathogen.
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公开(公告)号：US20150057175A1
公开(公告)日：2015-02-26
申请号：US14386940
申请日：2013-03-22
申请人： LABORATORIOS DEL DR. ESTEVE S.A. , FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA- CAIXA , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
IPC分类号： G01N33/68
CPC分类号： G01N33/6866 , G01N33/505 , G01N33/5091 , G01N33/56988 , G01N2333/15 , G01N2333/52 , G01N2333/525 , G01N2333/54 , G01N2333/555 , G01N2800/52 , G01N2800/56 , G01N2800/60
摘要： The invention relates to a method and a diagnostic kit for monitoring HIV specific T cell responses and identifying subjects capable of controlling HIV progression or preventing HIV infection altogether. The method is based on the combined use of boosted flow cytometry and toggle peptides and can cover a vastly larger set of effector functions than standard assays. The method is also suitable to detect T cell responses of any desirable cytokine or combination of cytokines to any pathogen
摘要翻译： 本发明涉及用于监测HIV特异性T细胞应答的方法和诊断试剂盒，并且确定能够完全控制HIV进展或预防HIV感染的受试者。 该方法基于加强流式细胞术和切换肽的组合使用，并且可以覆盖比标准测定法更大的一组效应子功能。 该方法还适用于检测任何所需细胞因子或细胞因子组合对任何病原体的T细胞应答
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