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公开(公告)号：US20150125489A1
公开(公告)日：2015-05-07
申请号：US14382398
申请日：2013-03-01
发明人： Felipe García Alcaide , Teresa Gallart , Nùria Climent Vidal , Cristina Gil Roda , Josep María Gatell Artigas
IPC分类号： C12N5/0784 , C12N7/00 , A61K39/21
CPC分类号： C12N5/0639 , A61K39/12 , A61K39/21 , A61K2039/5154 , A61K2039/5252 , C12N7/00 , C12N2501/02 , C12N2501/22 , C12N2501/2301 , C12N2501/2304 , C12N2501/2306 , C12N2501/25 , C12N2740/16034
摘要： The present invention relates to a process for obtaining an antigen-loaded dendritic cell showing higher viability and migratory capacity towards lymphatic nodes. The invention also relates to vaccines containing said dendritic cells as well as to the use thereof for the treatment of infectious diseases, especially AIDS.
摘要翻译： 本发明涉及获得具有较高存活力和对淋巴结转移能力的抗原负载型树突状细胞的方法。 本发明还涉及含有所述树突细胞的疫苗以及其用于治疗感染性疾病，特别是AIDS的用途。
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公开(公告)号：US10815278B2
公开(公告)日：2020-10-27
申请号：US15718635
申请日：2017-09-28
IPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N7/00 , A61K39/00
摘要： The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
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公开(公告)号：US09988425B2
公开(公告)日：2018-06-05
申请号：US14374334
申请日：2013-01-28
IPC分类号： A61K39/21 , C07K14/005 , C12N7/00 , A61K39/12 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/57 , A61K2039/575 , C07K2319/35 , C12N7/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including the immunogens.
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公开(公告)号：US09709577B2
公开(公告)日：2017-07-18
申请号：US14386940
申请日：2013-03-22
申请人： LABORATORIOS DEL DR. ESTEVE S.A. , FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
IPC分类号： G01N33/68 , G01N33/50 , G01N33/569
CPC分类号： G01N33/6866 , G01N33/505 , G01N33/5091 , G01N33/56988 , G01N2333/15 , G01N2333/52 , G01N2333/525 , G01N2333/54 , G01N2333/555 , G01N2800/52 , G01N2800/56 , G01N2800/60
摘要： The invention relates to a method and a diagnostic kit for monitoring HIV specific T cell responses and identifying subjects capable of controlling HIV progression or preventing HIV infection altogether. The method is based on the combined use of boosted flow cytometry and toggle peptides and can cover a large set of effector functions. The method is also suitable to detect T cell responses of any desirable cytokine or combination of cytokines to any pathogen.
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公开(公告)号：US11325946B2
公开(公告)日：2022-05-10
申请号：US15970216
申请日：2018-05-03
IPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N7/00 , A61K39/00
摘要： The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
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公开(公告)号：US09952218B2
公开(公告)日：2018-04-24
申请号：US14426235
申请日：2013-09-06
IPC分类号： G01N33/577 , C07K14/005 , G01N33/569 , C07K16/10 , C12N7/00
CPC分类号： G01N33/56988 , C07K14/005 , C07K16/1063 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2319/30 , C12N7/00 , C12N2740/16122 , G01N2333/162
摘要： The present invention relates to an in vitro method for determining HIV neutralizing antibodies in a sample. It further relates to a fusion protein to be used in said method and a nucleic acid encoding said fusion protein.
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公开(公告)号：US20150233924A1
公开(公告)日：2015-08-20
申请号：US14426235
申请日：2013-09-06
IPC分类号： G01N33/569 , C07K16/10 , C12N7/00 , C07K14/005
CPC分类号： G01N33/56988 , C07K14/005 , C07K16/1063 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2319/30 , C12N7/00 , C12N2740/16122 , G01N2333/162
摘要： The present invention relates to an in vitro method for determining HIV neutralizing antibodies in a sample. It further relates to a fusion protein to be used in said method and a nucleic acid encoding said fusion protein.
摘要翻译： 本发明涉及用于测定样品中的HIV中和抗体的体外方法。 还涉及用于所述方法的融合蛋白和编码所述融合蛋白的核酸。
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8.发明申请MYCOBACTERIUM COMPRISING EXPRESSION VECTOR WITH TWO AUXOTROPHIC SELECTION MARKERS AND ITS USE AS VACCINE 审中-公开包含两个AUXOTROPHIC选择标记的表达载体的MYCOBACTERIUM并用作疫苗公开(公告)号：US20150211012A1
公开(公告)日：2015-07-30
申请号：US14424545
申请日：2013-07-02
发明人： Joan Joseph , Narcis Saubi Roca
CPC分类号： C12N15/70 , A61K39/04 , A61K39/21 , A61K2039/523 , C12N15/74
摘要： The invention relates to polynucleotides and recombinant cell strains comprising the polynucleotides and the uses thereof for the delivery of the polypeptides encoded by the polynucleotides to a subject in need thereof. In particular, the invention refers to polynucleotides comprising a polypeptide of interest, auxotrophy-complementing genes and the use thereof in a mycobacterial double auxotrophic host cell to achieve the stable expression of the polypeptide of interest by using an antibiotic-free plasmid selection system.
摘要翻译： 本发明涉及包含多核苷酸的多核苷酸和重组细胞株及其用于将多核苷酸编码的多肽递送至有需要的受试者的用途。 特别地，本发明涉及包含感兴趣多肽的多核苷酸，营养缺陷型互补基因及其在分枝杆菌双营养缺陷型宿主细胞中的用途，以通过使用不含抗生素的质粒选择系统实现目标多肽的稳定表达。
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公开(公告)号：US20150057175A1
公开(公告)日：2015-02-26
申请号：US14386940
申请日：2013-03-22
申请人： LABORATORIOS DEL DR. ESTEVE S.A. , FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA- CAIXA , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
IPC分类号： G01N33/68
CPC分类号： G01N33/6866 , G01N33/505 , G01N33/5091 , G01N33/56988 , G01N2333/15 , G01N2333/52 , G01N2333/525 , G01N2333/54 , G01N2333/555 , G01N2800/52 , G01N2800/56 , G01N2800/60
摘要： The invention relates to a method and a diagnostic kit for monitoring HIV specific T cell responses and identifying subjects capable of controlling HIV progression or preventing HIV infection altogether. The method is based on the combined use of boosted flow cytometry and toggle peptides and can cover a vastly larger set of effector functions than standard assays. The method is also suitable to detect T cell responses of any desirable cytokine or combination of cytokines to any pathogen
摘要翻译： 本发明涉及用于监测HIV特异性T细胞应答的方法和诊断试剂盒，并且确定能够完全控制HIV进展或预防HIV感染的受试者。 该方法基于加强流式细胞术和切换肽的组合使用，并且可以覆盖比标准测定法更大的一组效应子功能。 该方法还适用于检测任何所需细胞因子或细胞因子组合对任何病原体的T细胞应答
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公开(公告)号：US20190055289A1
公开(公告)日：2019-02-21
申请号：US15970216
申请日：2018-05-03
IPC分类号： C07K14/005 , A61K39/21 , A61K39/12 , C12N7/00 , A61K39/00
摘要： The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
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