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1.发明申请公开(公告)号：US20180258449A1
公开(公告)日：2018-09-13
申请号：US15985042
申请日：2018-05-21
发明人： John McBride , Elena Brevnova , Mark Mellon , Allan Froehlich , Kristen Deleault , Vineet Rajgarhia , Riaan Den Haan , Merja Penttila , Marja Ilmen , Matti Siika-Aho , Jaana Uusitalo , Emily A. Stonehouse , Alan Gilbert , Haowen Xu , Deidre Willies , John Bardsley , Anu Koivula , Sanni Voutilainen
CPC分类号： C12P7/10 , C12N9/2437 , C12N9/2445 , C12N15/80 , C12P7/14 , C12P39/00 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
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2.发明申请公开(公告)号：US20210388398A1
公开(公告)日：2021-12-16
申请号：US17131293
申请日：2020-12-22
发明人： John McBride , Elena Brevnova , Mark Mellon , Allan Froehlich , Kristen Deleault , Vineet Rajgarhia , Riaan Den Haan , Merja Penttila , Marja Ilmen , Matti Siika-Aho , Jaana Uusitalo , Emily A. Stonehouse , Alan Gilbert , Haowen Xu , Deidre Willies , John Bardsley , Anu Koivula , Sanni Voutilainen
摘要： The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
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3.发明授权公开(公告)号：US09988652B2
公开(公告)日：2018-06-05
申请号：US14788879
申请日：2015-07-01
发明人： John McBride , Elena Brevnova , Mark Mellon , Allan Froehlich , Kristen Deleault , Vineet Rajgarhia , Riaan Den Haan , Merja Penttila , Marja Ilmen , Matti Siika-Aho , Jaana Uusitalo , Emily A. Stonehouse , Alan Gilbert , Haowen Xu , Deidre Willes , John Bardsley , Anu Koivula , Sanni Voutilainen
IPC分类号： C12N1/14 , C12N1/16 , C12N9/24 , C12N9/14 , C12N9/42 , C12P7/10 , C12N15/80 , C12P7/14 , C12P39/00 , A61K38/00
CPC分类号： C12P7/10 , C12N9/2437 , C12N9/2445 , C12N15/80 , C12P7/14 , C12P39/00 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluveryomyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
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4.发明申请YEAST EXPRESSING CELLULASES FOR SIMULTANEOUS SACCHARIFICATION AND FERMENTATION USING CELLULOSE 有权YEAST表达细胞同时发酵和发酵使用纤维素公开(公告)号：US20160010117A1
公开(公告)日：2016-01-14
申请号：US14788879
申请日：2015-07-01
发明人： John McBride , Elena Brevnova , Mark Mellon , Allan Froehlich , Kristen Deleault , Vineet Rajgarhia , Riaan Den Haan , Merja Penttila , Marja Ilmen , Matti Siika-Aho , Jaana Uusitalo , Emily A. Stonehouse , Alan Gilbert , Haowen Xu , Deidre Willes , John Bardsley , Anu Koivula , Sanni Voutilainen
CPC分类号： C12P7/10 , C12N9/2437 , C12N9/2445 , C12N15/80 , C12P7/14 , C12P39/00 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluveryomyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
摘要翻译： 本发明涉及纤维素分解宿主细胞。 表达异源纤维素酶的本发明的宿主细胞能够从纤维素中产生乙醇。 根据本发明，表达异源纤维素酶组合的宿主细胞可用于从纤维素生产乙醇。 此外，表达不同杂种纤维素酶的多个宿主细胞可以共同共培养并用于从纤维素生产乙醇。 此外，本发明首次证明了Kluveryomyces从纤维素中产生乙醇的能力。 本发明的酵母菌株的酵母菌株和共培养物可以独立地用于生产乙醇，也可以与外部添加的纤维素酶组合使用，以提高糖化和发酵过程的效率。
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