公开(公告)号：US20190381185A1

公开(公告)日：2019-12-19

申请号：US15779450

申请日：2016-11-23

Applicant: LEGOCHEM BIOSCIENCES, INC.

Inventor： Yong Zu Kim ,  Yeong Soo Oh ,  Jeiwook Chae ,  Ho Young Song ,  Chul-Woong Chung ,  Yun Hee Park ,  Hyo Jung Choi ,  Kyung Eun Park ,  Hyoungrae Kim ,  Jinyeong Kim ,  Ji Young Min ,  Sung Min Kim ,  Byung soo Lee ,  Dong Hyun Woo ,  Ji Eun Jung ,  Su In Lee

IPC: A61K47/68 ,  A61K47/65 ,  A61K45/06

Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and at least two active agents. In preferred embodiments, the linker comprises a peptide sequence of a plurality of amino acids, and at least two of the active agents are covalently coupled to side chains of the amino acids. The antibody-drug conjugate may comprise a self-immolative group, preferably two-self-immolative groups. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.