-
公开(公告)号：US11413353B2
公开(公告)日：2022-08-16
申请号：US15779446
申请日：2016-11-23
发明人： Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Yun Hee Park , Hyo Jung Choi , Kyung Eun Park , Hyoungrae Kim , Jinyeong Kim , Ji Young Min , Sung Min Kim , Byung Soo Lee , Dong Hyun Woo , Ji Eun Jung , Su In Lee
摘要： In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
-
公开(公告)号：US20180353611A1
公开(公告)日：2018-12-13
申请号：US16005245
申请日：2018-06-11
发明人： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jung Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC分类号： A61K47/68 , C07K19/00 , C07K16/32 , C07D519/00 , C07D487/04 , C07D249/04 , A61K47/54 , A61K47/69 , A61K39/00
CPC分类号： A61K47/6871 , A61K47/50 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24 , C07K2317/94
摘要： Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
-
公开(公告)号：US09919057B2
公开(公告)日：2018-03-20
申请号：US14865778
申请日：2015-09-25
发明人： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Jeon Yang , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung
IPC分类号： C07D309/10 , A61K47/48 , C07D249/04 , C07K19/00
CPC分类号： A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
摘要： Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
-
公开(公告)号：US20160184451A1
公开(公告)日：2016-06-30
申请号：US14865778
申请日：2015-09-25
发明人： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Jeon Yang , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung
IPC分类号： A61K47/48
CPC分类号： A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
摘要： Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
摘要翻译： 本发明提供的是包含自褪色基团的化合物，并且包含本发明的自褪色组的化合物可以包括具有底物特异性的蛋白质（例如寡肽，多肽，抗体等） 具有特定功能或活性的靶和活性剂（例如药物，毒素，配体，检测探针等）。
-
公开(公告)号：US20190381185A1
公开(公告)日：2019-12-19
申请号：US15779450
申请日：2016-11-23
发明人： Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Yun Hee Park , Hyo Jung Choi , Kyung Eun Park , Hyoungrae Kim , Jinyeong Kim , Ji Young Min , Sung Min Kim , Byung soo Lee , Dong Hyun Woo , Ji Eun Jung , Su In Lee
摘要： In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and at least two active agents. In preferred embodiments, the linker comprises a peptide sequence of a plurality of amino acids, and at least two of the active agents are covalently coupled to side chains of the amino acids. The antibody-drug conjugate may comprise a self-immolative group, preferably two-self-immolative groups. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
-
公开(公告)号：US10383949B2
公开(公告)日：2019-08-20
申请号：US16005245
申请日：2018-06-11
发明人： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC分类号： A61K47/68 , C07D249/04 , C07K19/00 , C07K16/32 , A61K47/69 , C07D487/04 , C07D519/00 , A61K47/54 , A61K47/50 , A61K39/00
摘要： Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
-
公开(公告)号：US20170095576A1
公开(公告)日：2017-04-06
申请号：US14898932
申请日：2015-05-27
发明人： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
CPC分类号： A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
摘要： Provided are methods of use of compounds comprising a self-immolative group, which compounds may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
-
公开(公告)号：US11173214B2
公开(公告)日：2021-11-16
申请号：US15779444
申请日：2016-11-23
发明人： Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Yun Hee Park , Hyo Jung Choi , Kyung Eun Park , Hyoungrae Kim , Jinyeong Kim , Ji Young Min , Sung Min Kim , Byung Soo Lee , Dong Hyun Woo , Ji Eun Jung , Su In Lee
摘要： The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody.
-
公开(公告)号：US10980890B2
公开(公告)日：2021-04-20
申请号：US16545869
申请日：2019-08-20
发明人： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC分类号： A61K47/54 , C07K19/00 , C07D487/04 , C07D519/00 , A61K47/68 , A61K47/50 , C07D249/04 , C07K16/32 , A61K47/69 , A61K39/00
摘要： Provided herein are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
-
公开(公告)号：US20200069816A1
公开(公告)日：2020-03-05
申请号：US16545869
申请日：2019-08-20
发明人： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC分类号： A61K47/68 , A61K47/69 , C07K16/32 , C07D249/04 , A61K47/54 , C07D519/00 , C07D487/04 , C07K19/00 , A61K47/50
摘要： Provided herein are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.024 秒)
