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公开(公告)号：US11413353B2
公开(公告)日：2022-08-16
申请号：US15779446
申请日：2016-11-23
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Yun Hee Park , Hyo Jung Choi , Kyung Eun Park , Hyoungrae Kim , Jinyeong Kim , Ji Young Min , Sung Min Kim , Byung Soo Lee , Dong Hyun Woo , Ji Eun Jung , Su In Lee
Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
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公开(公告)号：US20220339291A1
公开(公告)日：2022-10-27
申请号：US16964965
申请日：2020-03-05
Applicant: LegoChem Biosciences, Inc. , Y-Biologics, Inc.
Inventor： Chang Sik Park , Min Ji Choi , Tae Ik Jang , Yun-Hee Park , Ho Young Song , Ju Yuel Baek , Sung Min Kim , Hyeun Joung Lee , Ju Young Lee , Hyoung Rae Kim , Kun Jung Lee , Yong Zu Kim , Chang Sun Lee , Jeiwook Chae , Sang Pil Lee , Ji-Young Shin , Sunha Yoon , Yunseon Choi , Jae Eun Park , Jisu Lee , Bum-Chan Park , Young Woo Park
Abstract: The present invention relates to new antibody-drug conjugates (ADCs) targeting DLK1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically, uses for such ADCs in producing drugs for treatment and/or prevention of proliferative and/or angiogenetic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding with DLK1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
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公开(公告)号：US20170096430A1
公开(公告)日：2017-04-06
申请号：US15281355
申请日：2016-09-30
Applicant: LegoChem Biosciences, Inc.
Inventor： Hye Kyung Chang , Sung Yoon Baek , Min Jung Kim , Kyu Man Oh , Jeung Soon Choi , Soo Bong Ha , Sung Min Kim , Chul-woong Chung , Dae Hyuck Kang , Hyun Jin Kwon , Young Lag Cho , Yong Zu Kim
IPC: C07D471/08 , C07D519/00
CPC classification number: C07D471/08 , A61K31/46 , C07D519/00
Abstract: Substituted dihydroisoxazole derivatives useful as inhibitors of β-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.
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公开(公告)号：US11827703B2
公开(公告)日：2023-11-28
申请号：US16408002
申请日：2019-05-09
Applicant: LegoChem Biosciences, Inc. , NovImmune, SA
Inventor： Ho Young Song , Yun Hee Park , Sung Min Kim , Hyoung Rae Kim , Ji Hye Oh , Hyun Min Ryu , Jeiwook Chae , Yeong Soo Oh , Yong Zu Kim , Maureen Deehan , Nicolas Fischer
IPC: C07K16/28 , A61K47/68 , C07H15/203 , A61K31/5517 , A61K31/7052 , A61K45/06
CPC classification number: C07K16/2803 , A61K31/5517 , A61K31/7052 , A61K47/6803 , C07H15/203 , A61K45/06 , C07K2317/24 , C07K2317/31 , C07K2317/569 , C07K2317/622
Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD19, as well as methods of making and using these anti-CD19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：US20230272070A1
公开(公告)日：2023-08-31
申请号：US17946782
申请日：2022-09-16
Applicant: LegoChem Biosciences, Inc. , NovImmune, SA
Inventor： Ho Young Song , Yun Hee Park , Sung Min Kim , Hyoung Rae Kim , Ji Hye Oh , Hyun Min Ryu , Jeiwook Chae , Yeong Soo Oh , Yong Zu Kim , Maureen Deehan , Nicolas Fischer
IPC: C07K16/28 , A61K47/68 , C07H15/203 , A61K31/5517 , A61K31/7052
CPC classification number: C07K16/2803 , A61K47/6803 , C07H15/203 , A61K31/5517 , A61K31/7052 , A61K45/06
Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD19, as well as methods of making and using these anti-CD19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.
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Patent Agency Ranking
公开(公告)号：US20200095317A1
公开(公告)日：2020-03-26
申请号：US16408002
申请日：2019-05-09
Applicant: LegoChem Biosciences, Inc. , NovImmune, SA
Inventor： Ho Young Song , Yun Hee Park , Sung Min Kim , Hyoung Rae Kim , Ji Hye Oh , Hyun Min Ryu , Jeiwook Chae , Yeong Soo Oh , Yong Zu Kim , Maureen Deehan , Nicolas Fischer
IPC: C07K16/28 , A61K47/68 , C07H15/203
Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD19, as well as methods of making and using these anti-CD19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：US20190381185A1
公开(公告)日：2019-12-19
申请号：US15779450
申请日：2016-11-23
Applicant: LEGOCHEM BIOSCIENCES, INC.
Inventor： Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Yun Hee Park , Hyo Jung Choi , Kyung Eun Park , Hyoungrae Kim , Jinyeong Kim , Ji Young Min , Sung Min Kim , Byung soo Lee , Dong Hyun Woo , Ji Eun Jung , Su In Lee
Abstract: In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and at least two active agents. In preferred embodiments, the linker comprises a peptide sequence of a plurality of amino acids, and at least two of the active agents are covalently coupled to side chains of the amino acids. The antibody-drug conjugate may comprise a self-immolative group, preferably two-self-immolative groups. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
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公开(公告)号：US11707533B2
公开(公告)日：2023-07-25
申请号：US16940326
申请日：2020-07-27
Applicant: LegoChem Biosciences, Inc. , ABL Bio, Inc.
Inventor： Yun-Hee Park , Ho Young Song , Hyun Min Ryu , Sung Min Kim , Ju Yuel Baek , Ji Hye Oh , Nara Han , Hyoung Rae Kim , Kyung Eun Park , Hyeun Joung Lee , Ju Young Lee , Dae Hyuck Kang , Young-Jae Yang , Ji-Na You , Yong Zu Kim , Chang Sun Lee , Jeiwook Chae , Jinwon Jung , Juhee Kim , Bora Lee , Daehae Song , Byungje Sung , Donghoon Yeom , Jaehyun Eom , Youngeun Hong , Jinhyung Ahn , Yangsoon Lee , Kyungjin Park , Jiseon Yoo , Minji Park
CPC classification number: A61K47/6849 , A61K47/6803 , A61P35/00 , C07K16/2803
Abstract: The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
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公开(公告)号：US11173214B2
公开(公告)日：2021-11-16
申请号：US15779444
申请日：2016-11-23
Applicant: LegoChem Biosciences, Inc.
Inventor： Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Yun Hee Park , Hyo Jung Choi , Kyung Eun Park , Hyoungrae Kim , Jinyeong Kim , Ji Young Min , Sung Min Kim , Byung Soo Lee , Dong Hyun Woo , Ji Eun Jung , Su In Lee
Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody.
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公开(公告)号：US10273235B2
公开(公告)日：2019-04-30
申请号：US15917059
申请日：2018-03-09
Applicant: LegoChem Biosciences, Inc.
Inventor： Hye Kyung Chang , Sung Yoon Baek , Min Jung Kim , Kyu Man Oh , Jeung Soon Choi , Soo Bong Ha , Sung Min Kim , Chul-woong Chung , Dae Hyuck Kang , Hyun Jin Kwon , Young Lag Cho , Yong Zu Kim
IPC: A61K31/46 , C07D471/08 , C07D519/00
Abstract: Substituted dihydroisoxazole derivatives useful as inhibitors of β-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.
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