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公开(公告)号:US20220311933A1
公开(公告)日:2022-09-29
申请号:US17610462
申请日:2020-05-12
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor: Stefan FABRIS , Patric PELZER , Marco BINGEL
Abstract: A controller for providing an operational setting of an imaging device is configured to provide a user with a preferred operational setting for acquiring an image. The controller is also configured to receive a user input and generate a response information based on the user input, the response information indicating whether or not the image generated by the imaging device is accepted by the user. The controller is further configured to update the preferred operational setting using a machine learning algorithm based on the response information.
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公开(公告)号:US20220171176A1
公开(公告)日:2022-06-02
申请号:US17594181
申请日:2020-04-08
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor: Patric PELZER , Christian SCHUMANN
Abstract: A device for receiving samples in a microscope is provided. The device comprises a microtiter plate. The microtiter plate comprises an inner part with cavities for the samples and with an optically transparent bottom plate, which seals the cavities underneath and a frame which defines a supporting surface and is configured to hold the inner part at least in a first position. The bottom plate is arranged above the supporting surface in the first position of the inner part. The inner part is movable relative to the frame along a direction (A) perpendicular to the supporting surface.
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公开(公告)号:US20210149175A1
公开(公告)日:2021-05-20
申请号:US17082320
申请日:2020-10-28
Applicant: Leica Microsystems CMS GmbH
Inventor: Kai RITSCHEL , Marco BINGEL , Patric PELZER
Abstract: An optical imaging device for a microscope comprises a first optical system configured to form a first optical image corresponding to a first region of a sample in accordance with a first imaging mode, a second optical system configured to form a second optical image corresponding to a second region of said sample, wherein said first and second regions spatially coincide in a target region of said sample and said first and second imaging modes are different from each other, a memory storing first distortion correction data suitable for correcting a first optical distortion caused by said first optical system in said first optical image, second distortion correction data suitable for correcting a second optical distortion caused by said second optical system in said second optical image, and transformation data suitable for correcting positional misalignment between said first and second optical images, and a processor which is configured to process first image data representing said first optical image based on said first distortion correction data for generating first distortion corrected image data, to process second image data representing said second optical image based on said second distortion correction data for generating second distortion corrected image data; and to combine said first and second distortion corrected image data based on said transformation data for generating combined image data representing a combined image which corresponds to said target region of said object.
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公开(公告)号:US20230213750A1
公开(公告)日:2023-07-06
申请号:US18001081
申请日:2021-06-11
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor: Patric PELZER , Werner WITTKE , Gabriel Roberto DIAS , Oliver KEUL
IPC: G02B21/36 , G02B21/00 , G06F3/04847
CPC classification number: G02B21/368 , G02B21/0032 , G06F3/04847
Abstract: A computer-implemented method for determining a value for at least three setting parameters by means of an input unit in the form of a graphical user interface with an input cursor positionable in an input area is provided. At least two of the at least three setting parameters can be set independently of one another. The method includes determining a position of the input cursor within the input area; determining a coordinate of the position of the input cursor for each particular setting parameter of the at least three setting parameters as a function of a distance in each case of the position of the input cursor from at least one coordinate origin allocated to the particular setting parameter; and determining a value for each particular setting parameter of the at least three setting parameters as a function of the coordinate determined for each particular setting parameter.
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公开(公告)号:US20220057618A1
公开(公告)日:2022-02-24
申请号:US17413579
申请日:2019-12-12
Applicant: Leica Microsystems CMS GmbH
Inventor: Werner WITTKE , Patric PELZER
Abstract: A microscope system includes: at least one microscope component with electrically adjustable component parameters; a controller for generating electrical signals and transmitting the electrical signals to the at least one microscope component to set the electrically adjustable component parameters; and a computer having at least one display unit, the computer generating an input unit having a graphical user interface on the at least one display unit, at least three setting parameters being adjustable by the graphical user interface. The input unit has an input pointer that is positionable in an input area so as to set a respective value for the at least three setting parameters. A coordinate axis is defined in the input area for each of the at least three setting parameters, with at least one coordinate axis not being perpendicular to another coordinate axis. Values of the at least three setting parameters are determined by the coordinates.
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公开(公告)号:US20240219700A1
公开(公告)日:2024-07-04
申请号:US18396914
申请日:2023-12-27
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor: Volker SCHACHT , Patric PELZER , Heiko WAGNER
CPC classification number: G02B21/02 , G02B21/26 , G02B21/368
Abstract: A controller for a microscope is provided. The microscope includes a sample stage and an imaging optic. The sample stage is configured to receive a sample holder. The controller is configured to: control the microscope in a first mode, wherein a lateral position for all of at least two different objective lenses during a lateral movement is restricted to a first lateral range in at least one lateral direction; and control the microscope in a second mode, wherein the position for all of the at least two different objective lenses during the lateral movement is allowed to be at least within a second lateral range, different from the first lateral range, in the at least one lateral direction. In the second mode, a vertical position for the at least two different objective lenses during a vertical movement is restricted to a pre-defined vertical range.
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公开(公告)号:US20240201477A1
公开(公告)日:2024-06-20
申请号:US18287315
申请日:2022-04-19
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor: Patric PELZER , Claus BENDER
Abstract: A microscope for examining a sample includes a microscope stage for receiving the sample to be examined and further includes a microscope housing enclosing the microscope stage. The microscope housing includes a first access door and a second access door, whereby both the first access door and the second access door, upon opening, provide different ways of access to the microscope stage.
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公开(公告)号:US20220128809A1
公开(公告)日:2022-04-28
申请号:US17427965
申请日:2020-01-27
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor: Patric PELZER
Abstract: A method for image generation by means of a microscope includes: locating a sample to be imaged in an object space of the microscope for the image generation using specified image generation parameters; firstly detecting a movement or an intended movement of the sample; and thereupon automatically changing at least one image generation parameter during the movement of the sample depending on a movement variable.
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公开(公告)号:US20240272415A1
公开(公告)日:2024-08-15
申请号:US18438587
申请日:2024-02-12
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor: Gabriel-Roberto DIAS , Patric PELZER
IPC: G02B21/36 , G06F3/04842 , G06F3/04845
CPC classification number: G02B21/365 , G06F3/04842 , G06F3/04845 , G06F2203/04806
Abstract: A computer system for displaying sample images includes one or more processors configured to receive at least one sample image, each of the at least one sample images having been obtained by imaging a sample located in or on a sample holder using a microscope according to an imaging process; receive or generate spatial context information regarding the at least one sample image, the spatial context information having reference to the imaging process for obtaining the at least one sample image; and control a display to display the at least one sample image on the display based on the spatial context information regarding the at least one sample images.
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公开(公告)号:US20230196725A1
公开(公告)日:2023-06-22
申请号:US18065705
申请日:2022-12-14
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor: Patric PELZER , Markus OTT
IPC: G06V10/74 , G06T7/00 , G06V10/25 , G06F3/04812 , G06F3/04883 , G06F3/14
CPC classification number: G06V10/761 , G06T7/0012 , G06V10/25 , G06F3/04812 , G06F3/04883 , G06F3/14 , G06T2207/10056
Abstract: An image annotation system for annotating a microscopic image of a sample includes an output unit configured to display the image of the sample, and an input unit configured to capture a first and second user input sequence including a first and second movement of a cursor over the image, the first and second movement defining a first and second closed path. The image annotation system also includes a processor configured to determine a first image area, determine whether the second closed path includes at least one proximity section, when the second closed path does not include the proximity section, to determine a second image area, and when the second closed path does include the proximity section, to determine the second image area and at least one area between the border of the first image area and the at least one proximity section.
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