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公开(公告)号：US20220143068A1
公开(公告)日：2022-05-12
申请号：US17533533
申请日：2021-11-23
Applicant: LEMONEX INC.
Inventor： Cheol Hee WON , Jun KIM
IPC: A61K31/7105 , A61K31/713 , A61K47/69 , A61P35/00
Abstract: A nucleic acid carrier according to an embodiment of the present disclosure includes CpG-ODN-RNA conjugate and a porous silica particle carrying the conjugate inside pores thereof. In this regard, the nucleic acid carrier of the present invention can stably deliver loaded nucleic acid molecules to a body and release the same to a target, thereby increasing Type 1 interferon and exhibiting RNA-inherent functions.
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公开(公告)号：US20230346821A1
公开(公告)日：2023-11-02
申请号：US18203828
申请日：2023-05-31
Applicant: LEMONEX INC.
Inventor： Cheol Hee WON , Jun KIM
IPC: A61K31/7105 , A61K47/69 , A61K47/54 , A61K31/713 , A61P35/00
CPC classification number: A61K31/7105 , A61K31/713 , A61K47/549 , A61K47/6923 , A61P35/00 , B82Y5/00
Abstract: A nucleic acid carrier according to an embodiment of the present disclosure includes CpG-ODN-RNA conjugate and a porous silica particle carrying the conjugate inside pores thereof. In this regard, the nucleic acid carrier of the present invention can stably deliver loaded nucleic acid molecules to a body and release the same to a target, thereby increasing Type 1 interferon and exhibiting RNA-inherent functions.
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公开(公告)号：US20220280602A1
公开(公告)日：2022-09-08
申请号：US17630419
申请日：2020-07-31
Applicant: LEMONEX INC.
Inventor： Cheol Hee WON
Abstract: An anticancer drug according to an embodiment of the present disclosure includes porous silica particles having an anticancer active peptide incorporated therein. Nitrogen-containing groups are located on an outer surface of each porous silica particle, and folic acid is bound to at least some of the nitrogen-containing groups, whereby the anticancer drug has an excellent target delivery ability, is of high stability without forming a precipitate in an in-vivo environment, and is applicable to various carcinomas.
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公开(公告)号：US20220110964A1
公开(公告)日：2022-04-14
申请号：US17265386
申请日：2019-08-01
Applicant: LEMONEX INC.
Inventor： Cheol Hee WON
IPC: A61K31/7088 , A61K9/14 , C12N15/113
Abstract: A composition according to an embodiment includes porous silica particles carrying nucleic acid molecules that complementarily bind to at least a portion of thymic stromal lymphopoietin (TSLP) mRNA. The composition is capable of preventing or treating, with excellent efficiency, atopic diseases, such as bronchial asthma, allergic rhinitis, atopic dermatitis, allergic dermatitis or inflammatory skin diseases by effectively inhibiting the expression level of TSLP.
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Patent Agency Ranking
公开(公告)号：US20210230602A1
公开(公告)日：2021-07-29
申请号：US17162045
申请日：2021-01-29
Applicant: LEMONEX INC.
Inventor： Cheol Hee WON
IPC: C12N15/113 , A61K9/16 , C07K14/00 , A61P17/02
Abstract: A composition according to an embodiment of the present invention includes nucleic acid molecules which are capable of effectively inhibiting the expression level of connective tissue growth factor (CTGF) and collagen by RNA interference (RNAi), thereby preventing or treating a variety of fibroproliferative diseases due to overexpression of CTGF or collagen.
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公开(公告)号：US20210228670A1
公开(公告)日：2021-07-29
申请号：US17258312
申请日：2019-07-09
Applicant: LEMONEX INC.
Inventor： Cheol Hee WON , Jun KIM
IPC: A61K36/61 , A23L33/105 , A61K9/00 , A61P27/02
Abstract: A composition according to an embodiment of the present disclosure includes a banaba leaf extract, a guava leaf extract or a mixture thereof. The composition inhibits photooxidation of A2E due to blue light, inhibits a death of retinal pigment epithelial cells induced by blue light, and inhibits a damage to outer nuclear layers of visual cells in an animal model with blue light-induced macular degeneration, and thus can be beneficially used as a composition for preventing or treating macular degeneration and as a health functional food for preventing or alleviating macular degeneration.
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公开(公告)号：US20210309763A1
公开(公告)日：2021-10-07
申请号：US17264944
申请日：2019-07-31
Applicant: LEMONEX INC.
Inventor： Cheol Hee WON
Abstract: A composition according to an embodiment of the present disclosure includes porous artificial chaperone particles having an average pore diameter of 1 to 100 nm, thereby stapling an alpha helical polypeptide to immobilize a random coiled tertiary-structure of the polypeptide into a stable alpha-helix structure, and significantly improving stability and efficiency of the polypeptide.
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公开(公告)号：US20210228607A1
公开(公告)日：2021-07-29
申请号：US17051117
申请日：2019-04-24
Applicant: LEMONEX INC. , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventor： Cheol Hee WON , Dal Hee MIN
IPC: A61K31/7036 , A61K38/14 , A61K31/4706 , A61K31/5415 , A61K31/536 , A61K31/661 , A61K31/47 , A61K31/496 , A61K31/282 , A61K31/546 , A61K31/7048 , A61K38/12 , A61P31/14
Abstract: A method for treating a flavivirus infection includes administering to a subject in need thereof a composition which includes at least one of gentamicin sulfate, netilmicin, tobramycin, paromomycin, amikacin, capreomycin, trifluoperazine, dihydrostreptomycin, hydroxychloroquine, thioridazine HCl, efavirenz, miltefosine, nystatin, micafungin, bleomycin, resminostat, montelukast, norfloxacin, nedaplatin and cephalothin, which can exhibit excellent growth inhibition or killing effects of various species of flavivirus genus.
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公开(公告)号：US20210177988A1
公开(公告)日：2021-06-17
申请号：US17265692
申请日：2019-06-03
Applicant: LEMONEX INC.
Inventor： Cheol Hee WON
Abstract: An immunoreactive substance carrier according to an embodiment of the present invention may stably deliver various immunoreactive substances including antibodies and/or cytokines, to a target site, thereby exhibiting excellent immunotherapeutic effects. Therefore, a composition including the immunoreactive substance carrier can be used for immunotherapy, thereby having excellent effects in the prevention or treatment of cancer or various immune diseases.
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