公开(公告)号：US12138346B2

公开(公告)日：2024-11-12

申请号：US18368097

申请日：2023-09-14

Applicant: LEMONEX INC.

Inventor： Cheolhee Won

IPC: A61K9/16 ,  A61K31/203 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/711 ,  A61K31/713 ,  A61K38/17 ,  A61K38/46 ,  A61K39/395

Abstract: A bioactive substance delivery system includes a bioactive substance comprising nucleic acid, and a bioactive substance carrier comprising a porous silica particle having a plurality of pores with a diameter of 5 nm to 100 nm, and having not less than 24 hours at which a ratio of absorbance is ½. The porous silica particles may be positively charged inside the pore at neutral pH.

公开(公告)号：US20230346821A1

公开(公告)日：2023-11-02

申请号：US18203828

申请日：2023-05-31

Applicant: LEMONEX INC.

Inventor： Cheol Hee WON ,  Jun KIM

IPC: A61K31/7105 ,  A61K47/69 ,  A61K47/54 ,  A61K31/713 ,  A61P35/00

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61K47/549 ,  A61K47/6923 ,  A61P35/00 ,  B82Y5/00

Abstract: A nucleic acid carrier according to an embodiment of the present disclosure includes CpG-ODN-RNA conjugate and a porous silica particle carrying the conjugate inside pores thereof. In this regard, the nucleic acid carrier of the present invention can stably deliver loaded nucleic acid molecules to a body and release the same to a target, thereby increasing Type 1 interferon and exhibiting RNA-inherent functions.

公开(公告)号：US20220280602A1

公开(公告)日：2022-09-08

申请号：US17630419

申请日：2020-07-31

Applicant: LEMONEX INC.

Inventor： Cheol Hee WON

IPC: A61K38/17 ,  A61K9/16 ,  A61P35/00 ,  A61K47/69

Abstract: An anticancer drug according to an embodiment of the present disclosure includes porous silica particles having an anticancer active peptide incorporated therein. Nitrogen-containing groups are located on an outer surface of each porous silica particle, and folic acid is bound to at least some of the nitrogen-containing groups, whereby the anticancer drug has an excellent target delivery ability, is of high stability without forming a precipitate in an in-vivo environment, and is applicable to various carcinomas.

公开(公告)号：US20210093654A1

公开(公告)日：2021-04-01

申请号：US16634675

申请日：2018-07-30

Applicant: LEMONEX INC.

Inventor： Cheolhee WON

IPC: A61K31/713 ,  C12N15/113 ,  A61P35/00

Abstract: The present invention provides siRNA or dsRNA, which can effectively inhibit the expression of three highly expressed markers in liver cancer, and a pharmaceutical composition including the same can obtain excellent effects of preventing or treating liver cancer through RNAi. A pharmaceutical composition for preventing or treating liver cancer according to an embodiment of the present invention includes at least one of siRNA which includes a sense RNA having at least one sequence selected from the group consisting of sequences of SEQ ID NOs: 5 to 157, and an antisense RNA having a complementary sequence thereto and dsRNA having at least one sequence selected from the group consisting of sequences of SEQ ID NOs: 158 to 310.

公开(公告)号：US11793757B2

公开(公告)日：2023-10-24

申请号：US17399320

申请日：2021-08-11

Applicant: LEMONEX INC.

Inventor： Cheolhee Won

IPC: A61K9/16 ,  A61K31/203 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/711 ,  A61K31/713 ,  A61K38/17 ,  A61K38/46 ,  A61K39/395

CPC classification number: A61K9/1611 ,  A61K31/203 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/711 ,  A61K31/713 ,  A61K38/1758 ,  A61K38/465 ,  A61K39/395

Abstract: A porous silica particles according to an embodiment of the present disclosure includes a plurality of pores with a diameter of 5 nm to 100 nm. The porous silica particles have particular physical properties, can deliver all various drugs by a supported amount in a sustained manner, and can be parenterally administered.

公开(公告)号：US11786469B2

公开(公告)日：2023-10-17

申请号：US15328121

申请日：2015-03-31

Applicant: LEMONEX INC. ,  Cheolhee Won

Inventor： Cheolhee Won

IPC: A61K9/14 ,  A61K47/02 ,  A61K39/395 ,  A61K47/40 ,  A61K9/16 ,  B82Y5/00

CPC classification number: A61K9/143 ,  A61K9/145 ,  A61K9/16 ,  A61K39/395 ,  A61K47/02 ,  A61K47/40 ,  B82Y5/00

Abstract: A composition for delivering a bioactive material include a porous silica nanoparticle containing pores with an average pore diameter ranging from 1 nm to 100 nm, at least one of (i) a functional group which binds to the pore surface of the porous silica nanoparticle and gives the pore surface a negative charge or a positive charge, (ii) a ligand which binds to the pore surface of the porous silica nanoparticle and specifically binds to the bioactive material, and (iii) a combination of the functional group and the ligand, and a bioactive material having a size to be accommodated within the pores of the porous silica nanoparticle, the bioactive material bound to said at least one of the functional group and the ligand bound to the pore surface of the mesoporous silica nanoparticle and accommodated within the pores of the porous silica nanoparticle.

公开(公告)号：US20220143068A1

公开(公告)日：2022-05-12

申请号：US17533533

申请日：2021-11-23

Applicant: LEMONEX INC.

Inventor： Cheol Hee WON ,  Jun KIM

IPC: A61K31/7105 ,  A61K31/713 ,  A61K47/69 ,  A61P35/00

Abstract: A nucleic acid carrier according to an embodiment of the present disclosure includes CpG-ODN-RNA conjugate and a porous silica particle carrying the conjugate inside pores thereof. In this regard, the nucleic acid carrier of the present invention can stably deliver loaded nucleic acid molecules to a body and release the same to a target, thereby increasing Type 1 interferon and exhibiting RNA-inherent functions.

公开(公告)号：US20210137922A1

公开(公告)日：2021-05-13

申请号：US16476220

申请日：2018-01-08

Applicant: LEMONEX INC.

Inventor： Jae Ho LEE ,  Dal-Hee MIN ,  Cheolhee WON

IPC: A61K31/506 ,  A23L33/10 ,  A61K31/337 ,  A61K31/475 ,  A61K31/165 ,  A61K31/343 ,  A61K33/243 ,  A61P35/04

Abstract: A method for treatment of cancer selected from the group consisting of metastatic ovarian cancer, endometrial cancer, and breast cancer includes administering a composition comprising a compound represented by Formula 1, a pharmaceutically acceptable salt thereof to a subject in need thereof: The composition can efficiently kill cancer cells present in a spheroid form, thereby being usefully applied as novel medicament for metastatic ovarian cancer, endometrial cancer or breast cancer.

公开(公告)号：US20180306718A1

公开(公告)日：2018-10-25

申请号：US15765409

申请日：2016-06-15

Applicant: LEMONEX INC.

Inventor： Cheolhee WON ,  Dal-Hee MIN

IPC: G01N21/64 ,  C12N15/115 ,  C12N1/20 ,  C08B37/08 ,  G01N33/574

Abstract: A quencher containing water-soluble polymer-conjugated nanomaterial effectively quenches the fluorescence of a fluorescent material-conjugated probe. In addition, a composition including the quencher and a fluorescent material-conjugated probe can detect a target material existing at a low concentration, and thus can be favorably used as a composition or kit for providing information necessary for the detection of a biomaterial or the diagnosis of a disease.

公开(公告)号：US20250032414A1

公开(公告)日：2025-01-30

申请号：US18910379

申请日：2024-10-09

Applicant: LEMONEX INC.

Inventor： Cheolhee WON

IPC: A61K9/16 ,  A61K31/203 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/711 ,  A61K31/713 ,  A61K38/17 ,  A61K38/46 ,  A61K39/395

Abstract: A bioactive substance delivery system includes a bioactive substance comprising nucleic acid, and a bioactive substance carrier comprising a porous silica particle having a plurality of pores with a diameter of 5 nm to 100 nm, and having not less than 24 hours at which a ratio of absorbance is ½. The porous silica particles may be positively charged inside the pore at neutral pH.