公开(公告)号：US12295967B2

公开(公告)日：2025-05-13

申请号：US17051117

申请日：2019-04-24

Applicant: LEMONEX INC. ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Cheol Hee Won ,  Dal Hee Min

IPC: A61K31/7036 ,  A61K31/282 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/536 ,  A61K31/5415 ,  A61K31/546 ,  A61K31/661 ,  A61K31/7048 ,  A61K38/12 ,  A61K38/14 ,  A61P31/14

Abstract: A method for treating a flavivirus infection includes administering to a subject in need thereof a composition which includes at least one of gentamicin sulfate, netilmicin, tobramycin, paromomycin, amikacin, capreomycin, trifluoperazine, dihydrostreptomycin, hydroxychloroquine, thioridazine HCl, efavirenz, miltefosine, nystatin, micafungin, bleomycin, resminostat, montelukast, norfloxacin, nedaplatin and cephalothin, which can exhibit excellent growth inhibition or killing effects of various species of flavivirus genus.

公开(公告)号：US11701378B2

公开(公告)日：2023-07-18

申请号：US17533533

申请日：2021-11-23

Applicant: LEMONEX INC.

Inventor： Cheol Hee Won ,  Jun Kim

IPC: A61K31/7105 ,  A61K47/69 ,  A61K47/54 ,  A61P35/00 ,  A61K31/713 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61K47/549 ,  A61K47/6923 ,  A61P35/00 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C12N2310/351

Abstract: A nucleic acid carrier according to an embodiment of the present disclosure includes CpG-ODN-RNA conjugate and a porous silica particle carrying the conjugate inside pores thereof. In this regard, the nucleic acid carrier of the present invention can stably deliver loaded nucleic acid molecules to a body and release the same to a target, thereby increasing Type 1 interferon and exhibiting RNA-inherent functions.

公开(公告)号：US12234458B2

公开(公告)日：2025-02-25

申请号：US17162045

申请日：2021-01-29

Applicant: LEMONEX INC.

Inventor： Cheol Hee Won

IPC: C12N15/113 ,  A61K9/16 ,  A61P17/02 ,  C07K14/00

Abstract: A composition according to an embodiment of the present invention includes nucleic acid molecules which are capable of effectively inhibiting the expression level of connective tissue growth factor (CTGF) and collagen by RNA interference (RNAi), thereby preventing or treating a variety of fibroproliferative diseases due to overexpression of CTGF or collagen.

公开(公告)号：US11633447B2

公开(公告)日：2023-04-25

申请号：US17258312

申请日：2019-07-09

Applicant: LEMONEX INC.

Inventor： Cheol Hee Won ,  Jun Kim

IPC: A61K36/61 ,  A23L33/105 ,  A61P27/02 ,  A61K9/00

Abstract: A composition according to an embodiment of the present disclosure includes a banaba leaf extract, a guava leaf extract or a mixture thereof. The composition inhibits photooxidation of A2E due to blue light, inhibits a death of retinal pigment epithelial cells induced by blue light, and inhibits a damage to outer nuclear layers of visual cells in an animal model with blue light-induced macular degeneration, and thus can be beneficially used as a composition for preventing or treating macular degeneration and as a health functional food for preventing or alleviating macular degeneration.