公开(公告)号：US20240262809A1

公开(公告)日：2024-08-08

申请号：US18557775

申请日：2022-04-26

Applicant: LG CHEM, LTD.

Inventor： In Ae RYU ,  Ju Young LEE ,  Joo Yong YOON ,  Seok Ju LEE ,  Ah Byeol PARK ,  Ki Dae KIM ,  Hui Rak JEONG

IPC: C07D403/10

CPC classification number: C07D403/10

Abstract: The present invention relates to a novel method for preparing an intermediate of Chemical Formula 2, wherein the intermediate can be effectively used in the synthesis of a xanthine oxidase inhibitor.

公开(公告)号：US20240317716A1

公开(公告)日：2024-09-26

申请号：US18575570

申请日：2022-07-01

Applicant: LG CHEM, LTD.

Inventor： Seok Ju LEE ,  Hui Rak JEONG ,  Jin Ok HAM ,  Doo Sup SHIN

IPC: C07D403/04

CPC classification number: C07D403/04

Abstract: The present invention relates to a method for preparing a xanthine oxidase inhibitor and, more specifically, to a method for preparing a compound of chemical formula 2 by using ester hydrolysis and a recrystallization method.

公开(公告)号：US20240317685A1

公开(公告)日：2024-09-26

申请号：US18575630

申请日：2022-07-01

Applicant: LG CHEM, LTD.

Inventor： Seok Ju LEE ,  Ah Byeol PARK ,  Ju Yeol LEE ,  Ki Dae KIM ,  Hui Rak JEONG

IPC: C07D209/42 ,  C07D403/04

CPC classification number: C07D209/42 ,  C07D403/04

Abstract: The present invention relates to a method for preparing an intermediate for synthesis of a xanthine oxidase inhibitor and, more specifically, to a method for preparing compounds of chemical formulas 2 and 4 by using low-priced starting materials and ligands and employing chelating extraction and purification techniques.

公开(公告)号：US20240352001A1

公开(公告)日：2024-10-24

申请号：US18557786

申请日：2022-04-26

Applicant: LG CHEM, LTD.

Inventor： In Ae RYU ,  Ju Young LEE ,  Joo Yong YOON ,  Seok Ju LEE ,  Ah Byeol PARK ,  Ki Dae KIM ,  Hui Rak JEONG

IPC: C07D403/04

CPC classification number: C07D403/04

Abstract: The present invention relates to a novel method for preparing an intermediate of Chemical Formula 3, wherein the intermediate can be effectively used in the synthesis of a xanthine oxidase inhibitor.

公开(公告)号：US20240239768A1

公开(公告)日：2024-07-18

申请号：US18557276

申请日：2022-04-26

Applicant: LG CHEM, LTD.

Inventor： In Ae RYU ,  Ju Young LEE ,  Joo Yong YOON ,  Seok Ju LEE ,  Ah Byeol PARK ,  Ki Dae KIM ,  Hui Rak JEONG

IPC: C07D403/04

CPC classification number: C07D403/04

Abstract: The present invention relates to a novel preparation method that can be advantageously utilized for the synthesis of a xanthine oxidase inhibitor of Chemical Formula 1.

公开(公告)号：US20240000750A1

公开(公告)日：2024-01-04

申请号：US18251646

申请日：2021-11-02

Applicant: LG CHEM, LTD.

Inventor： Seok Ju LEE ,  Ah Byeol PARK ,  Hui Rak JEONG ,  Jinok HAM ,  Doosup SHIN

IPC: A61K31/4155 ,  A61K9/20

CPC classification number: A61K31/4155 ,  A61K9/2077

Abstract: The present invention relates to a pharmaceutical composition comprising crystalline particles comprising the compound of Formula 1 or a pharmaceutically acceptable salt thereof comprising the compound of Formula 2 below in an amount of 0.2 wt. % or less.
The crystalline particles according to the present invention, have a size, shape and distribution that improve uniformity and flowability as well as being optimized for input into the preparation process of the finished drug product, thereby increasing the content uniformity in the preparation process of the finished product and minimizing breakage during compressing into tablets, and thus can be used as a raw material pharmaceutical product suitable for the preparation process of the finished drug product.