公开(公告)号：US20240217935A1

公开(公告)日：2024-07-04

申请号：US18555021

申请日：2022-04-14

Applicant: LG CHEM, LTD.

Inventor： Sung Wook KIM ,  Ki Dae KIM ,  Soo Min LEE

IPC: C07D231/56 ,  C07C45/65

CPC classification number: C07D231/56 ,  C07C45/65

Abstract: The present invention relates to a novel method for preparing a compound of Formula 4 as described in the present description, which may be usefully used for the synthesis of a sphingosine-1-phoaphate receptor agonist.

公开(公告)号：US20240317685A1

公开(公告)日：2024-09-26

申请号：US18575630

申请日：2022-07-01

Applicant: LG CHEM, LTD.

Inventor： Seok Ju LEE ,  Ah Byeol PARK ,  Ju Yeol LEE ,  Ki Dae KIM ,  Hui Rak JEONG

IPC: C07D209/42 ,  C07D403/04

CPC classification number: C07D209/42 ,  C07D403/04

Abstract: The present invention relates to a method for preparing an intermediate for synthesis of a xanthine oxidase inhibitor and, more specifically, to a method for preparing compounds of chemical formulas 2 and 4 by using low-priced starting materials and ligands and employing chelating extraction and purification techniques.

公开(公告)号：US20240002322A1

公开(公告)日：2024-01-04

申请号：US18248721

申请日：2021-10-12

Applicant: LG CHEM, LTD.

Inventor： Sung Wook KIM ,  Ki Dae KIM ,  Soo Min LEE ,  Ho Yeon LEE ,  Jin Ok HAM

IPC: C07C45/67 ,  C07C67/29

CPC classification number: C07C45/676 ,  C07B2200/13 ,  C07C67/29

Abstract: The present invention relates to a novel method for producing an intermediate expressed by chemical formula 5 that can be effectively used in synthesis of sphingosine-1-phosphate receptor agonist.

公开(公告)号：US20240262809A1

公开(公告)日：2024-08-08

申请号：US18557775

申请日：2022-04-26

Applicant: LG CHEM, LTD.

Inventor： In Ae RYU ,  Ju Young LEE ,  Joo Yong YOON ,  Seok Ju LEE ,  Ah Byeol PARK ,  Ki Dae KIM ,  Hui Rak JEONG

IPC: C07D403/10

CPC classification number: C07D403/10

Abstract: The present invention relates to a novel method for preparing an intermediate of Chemical Formula 2, wherein the intermediate can be effectively used in the synthesis of a xanthine oxidase inhibitor.

公开(公告)号：US20240228461A1

公开(公告)日：2024-07-11

申请号：US18555233

申请日：2022-04-14

Applicant: LG CHEM, LTD.

Inventor： Sung Wook KIM ,  Ki Dae KIM ,  Soo Min LEE ,  Doo Sup SHIN

IPC: C07D401/12 ,  C07D231/56

CPC classification number: C07D401/12 ,  C07D231/56

Abstract: The present invention relates to a novel method for preparing a compound of chemical Formula 7, or a salt thereof, which is disclosed in the present specification and can be effectively used as a sphingosine-1-phosphate receptor agonist.

公开(公告)号：US20240208930A1

公开(公告)日：2024-06-27

申请号：US18555218

申请日：2022-04-13

Applicant: LG CHEM, LTD.

Inventor： Ji Yoon KIM ,  Seul Ah CHUN ,  Sung Wook KIM ,  Sung Won KIM ,  Ki Dae KIM ,  Soo Min LEE

IPC: C07D401/12 ,  A61K31/454

CPC classification number: C07D401/12 ,  A61K31/454

Abstract: The present invention relates to a crystalline form of a sphingosine-1-phosphate receptor agonist and, more particularly, to a crystalline form0- of 1-[1-chloro-6-(3-chloro-1-isopropyl-1H-indazol-5-ylmethoxy)-3,4-dihydro-naphthalen-2-ylmethyl]-piperidine-4-carboxylic acid of chemical formula 1 or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240352001A1

公开(公告)日：2024-10-24

申请号：US18557786

申请日：2022-04-26

Applicant: LG CHEM, LTD.

Inventor： In Ae RYU ,  Ju Young LEE ,  Joo Yong YOON ,  Seok Ju LEE ,  Ah Byeol PARK ,  Ki Dae KIM ,  Hui Rak JEONG

IPC: C07D403/04

CPC classification number: C07D403/04

Abstract: The present invention relates to a novel method for preparing an intermediate of Chemical Formula 3, wherein the intermediate can be effectively used in the synthesis of a xanthine oxidase inhibitor.

公开(公告)号：US20240239768A1

公开(公告)日：2024-07-18

申请号：US18557276

申请日：2022-04-26

Applicant: LG CHEM, LTD.

Inventor： In Ae RYU ,  Ju Young LEE ,  Joo Yong YOON ,  Seok Ju LEE ,  Ah Byeol PARK ,  Ki Dae KIM ,  Hui Rak JEONG

IPC: C07D403/04

CPC classification number: C07D403/04

Abstract: The present invention relates to a novel preparation method that can be advantageously utilized for the synthesis of a xanthine oxidase inhibitor of Chemical Formula 1.

公开(公告)号：US20240228441A1

公开(公告)日：2024-07-11

申请号：US18555025

申请日：2022-04-14

Applicant: LG CHEM, LTD.

Inventor： Sung Wook KIM ,  Ki Dae KIM ,  Soo Min LEE ,  In Hwan CHOI

IPC: C07D231/56

CPC classification number: C07D231/56

Abstract: The present invention relates to a novel method for preparing a compound of represented by Formula 4 set forth in the present specification, wherein the compound can be effectively used for the synthesis of a sphingosine-1-phosphate receptor agonist.