公开(公告)号：US20200085976A1

公开(公告)日：2020-03-19

申请号：US16687450

申请日：2019-11-18

Applicant: LI-COR, INC.

Inventor： Daniel R. Draney ,  William M. Volcheck ,  Katie Schaepe ,  Vassil Elitzin ,  Joy Kovar

IPC: A61K49/00 ,  A61B5/20 ,  A61B5/00 ,  C09B23/10 ,  C09B23/08 ,  C09B23/01

Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

公开(公告)号：US20180339048A1

公开(公告)日：2018-11-29

申请号：US16046748

申请日：2018-07-26

Applicant: LI-COR, Inc.

Inventor： David L. Dilley ,  Joy Kovar

IPC: A61K41/00 ,  A61N5/06 ,  A61M1/36 ,  A61K51/08 ,  A61K51/04 ,  A61K49/00 ,  A61K47/68 ,  A61K47/64

Abstract: The present invention provides compositions and methods of use of nanoparticle-based probes for in vivo imaging and therapy. The probes can be used to track diseased target cells by non-invasive imaging in the near-infrared range. Additionally, the probes can induce cell death of the target cells via photodynamic treatment.

公开(公告)号：US11167046B2

公开(公告)日：2021-11-09

申请号：US16687450

申请日：2019-11-18

Applicant: LI-COR, INC.

Inventor： Daniel R. Draney ,  William M. Volcheck ,  Katie Schaepe ,  Vassil Elitzin ,  Joy Kovar

IPC: A61K49/00 ,  C09B23/10 ,  A61B5/00 ,  A61B5/20 ,  C09B23/01 ,  C09B23/08

Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

公开(公告)号：US10064943B2

公开(公告)日：2018-09-04

申请号：US14728247

申请日：2015-06-02

Applicant: LI-COR, INC.

Inventor： David L. Dilley ,  Joy Kovar

IPC: A61K41/00 ,  A61K49/00 ,  A61K51/08 ,  A61K47/48 ,  A61N5/06 ,  A61M1/36 ,  A61K51/04 ,  A61K47/64 ,  A61K47/68

Abstract: The present invention provides compositions and methods of use of nanoparticle-based probes for in vivo imaging and therapy. The probes can be used to track diseased target cells by non-invasive imaging in the near-infrared range. Additionally, the probes can induce cell death of the target cells via photodynamic treatment.