公开(公告)号：US20240428885A1

公开(公告)日：2024-12-26

申请号：US18748533

申请日：2024-06-20

Applicant: Life Technologies Corporation

Inventor： Fiona Hyland ,  Asha Kamat ,  Timothy Looney

IPC: G16B20/20 ,  G06F16/2457 ,  G06F16/248 ,  G06N3/126

Abstract: The method includes compressing numbers of reads data for targeted genes of a gene expression assay performed on a test sample. The targeted genes are organized into categories. Each category represents a functional context associated with the targeted genes in that category. The numbers of reads corresponding to targeted genes each category is compressed to form a compressed value for the category. The compressed value is compared to a baseline value for the category to determine an enrichment or a loss of a signature corresponding to the functional context of the category. The method may include analyzing information from multiple assays performed on the test sample, assigning a score value to each assay result and predicting a response to immune-oncology treatment based on the assigned scores.

公开(公告)号：US11610648B2

公开(公告)日：2023-03-21

申请号：US16851472

申请日：2020-04-17

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Fiona Hyland ,  Asha Kamat ,  Timothy Looney

IPC: G16B20/20 ,  G06F16/2457 ,  G06F16/248 ,  G06N3/126

Abstract: The method includes compressing numbers of reads data for targeted genes of a gene expression assay performed on a test sample. The targeted genes are organized into categories. Each category represents a functional context associated with the targeted genes in that category. The numbers of reads corresponding to targeted genes each category is compressed to form a compressed value for the category. The compressed value is compared to a baseline value for the category to determine an enrichment or a loss of a signature corresponding to the functional context of the category. The method may include analyzing information from multiple assays performed on the test sample, assigning a score value to each assay result and predicting a response to immune-oncology treatment based on the assigned scores.

公开(公告)号：US20230282306A1

公开(公告)日：2023-09-07

申请号：US18170797

申请日：2023-02-17

Applicant: Life Technologies Corporation

Inventor： Fiona Hyland ,  Asha Kamat ,  Timothy Looney

IPC: G16B20/20 ,  G06F16/2457 ,  G06F16/248 ,  G06N3/126

CPC classification number: G16B20/20 ,  G06F16/24575 ,  G06F16/248 ,  G06N3/126

Abstract: The method includes compressing numbers of reads data for targeted genes of a gene expression assay performed on a test sample. The targeted genes are organized into categories. Each category represents a functional context associated with the targeted genes in that category. The numbers of reads corresponding to targeted genes each category is compressed to form a compressed value for the category. The compressed value is compared to a baseline value for the category to determine an enrichment or a loss of a signature corresponding to the functional context of the category. The method may include analyzing information from multiple assays performed on the test sample, assigning a score value to each assay result and predicting a response to immune-oncology treatment based on the assigned scores.

公开(公告)号：US12040048B2

公开(公告)日：2024-07-16

申请号：US18170797

申请日：2023-02-17

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Fiona Hyland ,  Asha Kamat ,  Timothy Looney

IPC: G16B20/20 ,  G06F16/2457 ,  G06F16/248 ,  G06N3/126

CPC classification number: G16B20/20 ,  G06F16/24575 ,  G06F16/248 ,  G06N3/126

Abstract: The method includes compressing numbers of reads data for targeted genes of a gene expression assay performed on a test sample. The targeted genes are organized into categories. Each category represents a functional context associated with the targeted genes in that category. The numbers of reads corresponding to targeted genes each category is compressed to form a compressed value for the category. The compressed value is compared to a baseline value for the category to determine an enrichment or a loss of a signature corresponding to the functional context of the category. The method may include analyzing information from multiple assays performed on the test sample, assigning a score value to each assay result and predicting a response to immune-oncology treatment based on the assigned scores.