公开(公告)号：US20160265065A1

公开(公告)日：2016-09-15

申请号：US15068011

申请日：2016-03-11

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Santhoshi BANDLA ,  Douglas ROSS ,  Seth SADIS ,  Peter WYNGAARD

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The disclosure provides compositions, kits, and methods for detecting a plurality of genes and associated variants in a sample from a subject with lung cancer. The compositions, kits, and methods include a set of oligonucleotides, typically primers and/or probes that can hybridize to identify a gene variant. The methods disclosed herein provide for a mutation status of a tumor to be determined and subsequently associated with an actionable treatment recommendation.

Abstract translation: 本公开提供了用于检测来自患有肺癌的受试者的样品中的多种基因和相关变体的组合物，试剂盒和方法。 组合物，试剂盒和方法包括一组寡核苷酸，通常可以杂交以鉴定基因变体的引物和/或探针。 本文公开的方法提供待确定的肿瘤的突变状态，并随后与可行动治疗推荐相关联。