公开(公告)号：US20160265065A1

公开(公告)日：2016-09-15

申请号：US15068011

申请日：2016-03-11

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Santhoshi BANDLA ,  Douglas ROSS ,  Seth SADIS ,  Peter WYNGAARD

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The disclosure provides compositions, kits, and methods for detecting a plurality of genes and associated variants in a sample from a subject with lung cancer. The compositions, kits, and methods include a set of oligonucleotides, typically primers and/or probes that can hybridize to identify a gene variant. The methods disclosed herein provide for a mutation status of a tumor to be determined and subsequently associated with an actionable treatment recommendation.

Abstract translation: 本公开提供了用于检测来自患有肺癌的受试者的样品中的多种基因和相关变体的组合物，试剂盒和方法。 组合物，试剂盒和方法包括一组寡核苷酸，通常可以杂交以鉴定基因变体的引物和/或探针。 本文公开的方法提供待确定的肿瘤的突变状态，并随后与可行动治疗推荐相关联。

公开(公告)号：US20150315657A1

公开(公告)日：2015-11-05

申请号：US14672066

申请日：2015-03-27

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Daniel RHODES ,  Seth SADIS ,  Peter WYNGAARD ,  Nikolay KHAZANOV ,  Santhoshi BANDLA ,  Mark TOMILO ,  Sean EDDY ,  Emma BOWDEN ,  Jia LI

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24

Abstract: The disclosure provides gene fusions, gene variants, and novel associations with disease states, as well as kits, probes, and methods of using the same.

Abstract translation: 本公开提供了基因融合，基因变体和与疾病状态的新型关联，以及试剂盒，探针和使用它们的方法。

公开(公告)号：US20190040472A1

公开(公告)日：2019-02-07

申请号：US16103516

申请日：2018-08-14

Applicant: Life Technologies Corporation

Inventor： Daniel RHODES ,  Seth SADIS ,  Peter WYNGAARD ,  Nikolay KHAZANOV ,  Santhoshi BANDLA ,  Mark TOMILO ,  Sean EDDY ,  Emma BOWDEN ,  Jia LI

IPC: C12Q1/6886 ,  G06F19/24 ,  G06F19/22 ,  G06F19/18

Abstract: The disclosure provides gene fusions, gene variants, and novel associations with disease states, as well as kits, probes, and methods of using the same.

公开(公告)号：US20140288116A1

公开(公告)日：2014-09-25

申请号：US14212115

申请日：2014-03-14

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Santhoshi BANDLA ,  Douglas Ross ,  Seth Sadis ,  Peter Wyngaard

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The disclosure provides compositions, kits, and methods for detecting a plurality of genes and associated variants in a sample from a subject with lung cancer. The compositions, kits, and methods include a set of oligonucleotides, typically primers and/or probes that can hybridize to identify a gene variant. The methods disclosed herein provide for a mutation status of a tumor to be determined and subsequently associated with an actionable treatment recommendation.

Abstract translation: 本公开提供了用于检测来自患有肺癌的受试者的样品中的多种基因和相关变体的组合物，试剂盒和方法。 组合物，试剂盒和方法包括一组寡核苷酸，通常可以杂交以鉴定基因变体的引物和/或探针。 本文公开的方法提供待确定的肿瘤的突变状态，并随后与可行动治疗推荐相关联。