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1.发明申请公开(公告)号：US20170114321A1
公开(公告)日：2017-04-27
申请号：US15354241
申请日：2016-11-17
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Ronald BERENSON , Mark BONYHADI , Dale KALAMASZ
IPC: C12N5/00 , A61K35/17 , C12N5/0783
CPC classification number: C12N5/0087 , A61K35/17 , C12N5/0636 , C12N2501/48 , C12N2502/1114 , Y02A50/475
Abstract: The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g., autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.
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2.发明申请公开(公告)号：US20200071663A1
公开(公告)日：2020-03-05
申请号：US16534658
申请日：2019-08-07
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Ronald BERENSON , Mark BONYHADI , Dale KALAMASZ
IPC: C12N5/00 , A61K35/17 , C12N5/0783
Abstract: The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g., autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.
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3.发明申请METHODS FOR ELIMINATING AT LEAST A SUBSTANTIAL PORTION OF A CLONAL ANTIGEN-SPECIFIC MEMORY T CELL SUBPOPULATION 有权至少消除克隆抗原特异性记忆细胞SUBPOPULATION的重要部分的方法公开(公告)号：US20140234281A1
公开(公告)日：2014-08-21
申请号：US14086841
申请日：2013-11-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Ronald BERENSON , Mark BONYHADI , Dale KALAMASZ
IPC: C12N5/0783 , A61K35/14
CPC classification number: C12N5/0087 , A61K35/17 , C12N5/0636 , C12N2501/48 , C12N2502/1114 , Y02A50/475
Abstract: The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g., autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.
Abstract translation: 本发明一般涉及用于刺激T细胞的方法，更具体地，涉及从T细胞的混合群体中消除T细胞的不希望的（例如，自身反应，同种异体反应，致病）亚群的方法，从而恢复所述T细胞的正常免疫谱 T细胞。 本发明还涉及细胞的组合物，包括具有恢复的免疫谱的刺激的T细胞及其用途。
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