公开(公告)号：US20220002716A1

公开(公告)日：2022-01-06

申请号：US17364956

申请日：2021-07-01

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Anilkumar KORE ,  Senthilvelan ANNAMALAI ,  Shanmugasundaram MUTHIAN ,  Robert POTTER ,  Tyson VONDERFECHT

IPC: C12N15/11 ,  C07H21/00 ,  C12N9/12 ,  A61K31/7088 ,  A61K47/54 ,  A61K38/45

Abstract: This specification generally relates to trinucleotide RNA cap analogs, methods of use thereof, and kits comprising same. In particular, the trinucleotide cap analogs provided herein permit ready detection and/or isolation of capped RNA transcripts in vitro and translation of capped mRNAs in vivo.