公开(公告)号：US20190060482A1

公开(公告)日：2019-02-28

申请号：US16038107

申请日：2018-07-17

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Shikha MISHRA ,  Xavier de MOLLERAT du JEU

IPC: A61K47/69 ,  A61K9/127 ,  C12N9/22 ,  A61K31/7105 ,  A61K47/54 ,  A61P11/00

Abstract: Provided herein are, inter alia, compositions and methods useful for the in vivo delivery of bioactive agents (e.g., therapeutic or diagnostic agents). The compositions provided herein include cationic lipids, helper lipids and a biostability enhancing agent, which together form a lipid aggregate with the bioactive agent and allow for the systemic delivery of the bioactive agent to, for example, lung tissue without the requirement for biomolecular targeting.

公开(公告)号：US20220001023A1

公开(公告)日：2022-01-06

申请号：US17378466

申请日：2021-07-16

Applicant: Life Technologies Corporation

Inventor： Shikha MISHRA ,  Xavier de MOLLERAT du JEU

IPC: A61K47/69 ,  A61K9/127 ,  A61P11/00 ,  A61K31/7105 ,  A61K47/54 ,  C12N9/22 ,  C12N15/88 ,  A61K31/713 ,  A61K9/00

Abstract: Provided herein are, inter alia, compositions and methods useful for the in vivo delivery of bioactive agents (e.g., therapeutic or diagnostic agents). The compositions provided herein include cationic lipids, helper lipids and a biostability enhancing agent, which together form a lipid aggregate with the bioactive agent and allow for the systemic delivery of the bioactive agent to, for example, lung tissue without the requirement for biomolecular targeting.