公开(公告)号：US20180087056A1

公开(公告)日：2018-03-29

申请号：US15724224

申请日：2017-10-03

Applicant: Life Technologies Corporation

Inventor： Tod WOOLF ,  Margaret TAYLOR

IPC: C12N15/113 ,  A61K31/713 ,  C12N15/11

CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

公开(公告)号：US20170321219A1

公开(公告)日：2017-11-09

申请号：US15652219

申请日：2017-07-17

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tod WOOLF ,  Margaret Taylor

IPC: C12N15/113 ,  A61K31/713 ,  C12N15/11

CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

公开(公告)号：US20190017051A1

公开(公告)日：2019-01-17

申请号：US16015009

申请日：2018-06-21

Applicant: Life Technologies Corporation

Inventor： Tod WOOLF ,  Margaret TAYLOR

IPC: C12N15/113 ,  C12N15/11 ,  A61K31/713

Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

公开(公告)号：US20170137816A1

公开(公告)日：2017-05-18

申请号：US15418653

申请日：2017-01-27

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tod WOOLF ,  Kristin Wiederholt

IPC: C12N15/113 ,  C12N13/00

CPC classification number: C12N15/113 ,  A61K31/713 ,  C12N13/00 ,  C12N15/111 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/33 ,  C12N2310/351 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2320/51 ,  C12Y207/11022 ,  C12Y301/03048

Abstract: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.

公开(公告)号：US20150099797A1

公开(公告)日：2015-04-09

申请号：US14571588

申请日：2014-12-16

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tod WOOLF ,  Margaret Taylor

IPC: C12N15/113

CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

Abstract translation: 本发明的寡核苷酸组合物利用寡核苷酸的组合。 一方面，本发明的特征在于包含靶向靶基因的至少2种不同寡核苷酸的寡核苷酸组合。 本发明还提供了抑制细胞中蛋白质合成的方法以及鉴定抑制细胞中蛋白质合成的寡核苷酸组合物的方法。