公开(公告)号：US10168339B2

公开(公告)日：2019-01-01

申请号：US14371655

申请日：2012-12-27

申请人： LION CORPORATION

发明人： Chiyoko Uchiyama ,  Kei Kurita ,  Eriko Fukushima ,  Riichi Maki

IPC分类号： C07K14/575 ,  C07K14/705 ,  C07K16/26 ,  C07K16/28 ,  C12M1/34 ,  G01N27/62 ,  G01N37/00 ,  G01N33/68 ,  C07K14/72 ,  C07K14/47 ,  G01N33/543 ,  C07K14/435

摘要： It is an object of the present invention to provide a marker substance capable of accurately determining a risk of developing metabolic syndrome in vivo. That is, the present invention provides the followings: a marker peptide for determining the risk of developing the metabolic syndrome; an antibody or an aptamer bound to the marker peptide for determining the risk of developing the metabolic syndrome; a microarray in which the antibody or the aptamer bound to the marker peptide for determining the risk of developing the metabolic syndrome has been immobilized on a carrier; a method for determining the risk of developing the metabolic syndrome, comprising measuring an amount or the presence or absence of the marker peptide for determining the risk of developing the metabolic syndrome in a biological sample collected from a subject; and a kit for determining the risk of developing the metabolic syndrome, comprising the antibody or the aptamer or comprising the microarray.

公开(公告)号：US20150160239A1

公开(公告)日：2015-06-11

申请号：US14371655

申请日：2012-12-27

申请人： LION CORPORATION

发明人： Chiyoko Uchiyama ,  Kei Kurita ,  Eriko Fukushima ,  Riichi Maki

IPC分类号： G01N33/68 ,  C07K14/435

CPC分类号： G01N33/6893 ,  C07K14/435 ,  C07K14/47 ,  C07K14/723 ,  G01N33/54366 ,  G01N2333/435 ,  G01N2800/04 ,  G01N2800/50

摘要： It is an object of the present invention to provide a marker substance capable of accurately determining a risk of developing metabolic syndrome in vivo. That is, the present invention provides the followings: a marker peptide for determining the risk of developing the metabolic syndrome; an antibody or an aptamer bound to the marker peptide for determining the risk of developing the metabolic syndrome; a microarray in which the antibody or the aptamer bound to the marker peptide for determining the risk of developing the metabolic syndrome has been immobilized on a carrier; a method for determining the risk of developing the metabolic syndrome, comprising measuring an amount or the presence or absence of the marker peptide for determining the risk of developing the metabolic syndrome in a biological sample collected from a subject; and a kit for determining the risk of developing the metabolic syndrome, comprising the antibody or the aptamer or comprising the microarray.

摘要翻译： 本发明的目的是提供一种能够准确地确定体内发生代谢综合征风险的标记物质。 也就是说，本发明提供以下内容：用于确定发生代谢综合征的风险的标记肽; 与标记肽结合的抗体或适配体，用于确定发生代谢综合征的风险; 其中与标记肽结合的抗体或适配体用于确定发展代谢综合征的风险的微阵列已经固定在载体上; 用于确定发生代谢综合征的风险的方法，包括测量用于确定从受试者收集的生物样品中发生代谢综合征的风险的标记肽的量或存在或不存在; 以及用于确定发展代谢综合征的风险的试剂盒，其包含抗体或适体或包含微阵列。