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公开(公告)号：US20180094231A1
公开(公告)日：2018-04-05
申请号：US15285656
申请日：2016-10-05
申请人： Lonza Ltd.
发明人： Michael Mietzner , Jim Heimbach , Andrew Harris
IPC分类号： C12M1/12
摘要： Improved biopharmaceutical processing equipment such as reactor vessels and stainless steel surfaces, and methods of determining the same are disclosed herein. In some embodiments, a biopharmaceutical processing equipment can include a vessel having a surface that is configured to contact proteinaceous processing material, wherein the surface has a pre-commissioning surface roughness of greater than about 20 Ra Max (μin).
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公开(公告)号：US20200003316A1
公开(公告)日：2020-01-02
申请号：US16558655
申请日：2019-09-03
申请人： Lonza Ltd
发明人： Michael Mietzner
摘要： A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. The rupture membrane is positioned within the body such that the rupture membrane does not extend beyond the first end of the body. A process system including the rupture disk is also provided. A method of maintaining a process system that includes the rupture disk is also provided.
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公开(公告)号：US20180163882A1
公开(公告)日：2018-06-14
申请号：US15836646
申请日：2017-12-08
申请人： LONZA LTD
发明人： Michael Mietzner
摘要： A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. The rupture membrane is positioned within the body such that the rupture membrane does not extend beyond the first end of the body. A process system including the rupture disk is also provided. A method of maintaining a process system that includes the rupture disk is also provided.
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公开(公告)号：US10808216B2
公开(公告)日：2020-10-20
申请号：US15285656
申请日：2016-10-05
申请人： Lonza Ltd.
发明人： Michael Mietzner , Jim Heimbach , Andrew Harris
摘要： Improved biopharmaceutical processing equipment such as reactor vessels and stainless steel surfaces, and methods of determining the same are disclosed herein. In some embodiments, a biopharmaceutical processing equipment can include a vessel having a surface that is configured to contact proteinaceous processing material, wherein the surface has a pre-commissioning surface roughness of greater than about 20 Ra Max (μin).
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5.发明申请公开(公告)号：US20200147556A1
公开(公告)日：2020-05-14
申请号：US16677786
申请日：2019-11-08
申请人： Lonza Ltd.
发明人： Michael Mietzner
摘要： A process and system for cleaning semipermeable membranes is described that is particularly well suited for cleaning membranes contained in a water purification system, such as a reverse osmosis process. In order to clean the filter membranes, the membranes are placed in a cleaning chamber capable of allowing a reduction in pressure. In one embodiment, for instance, the membranes are contained in a filter housing and the filter housing is converted into a cleaning chamber by sealing off at least one end. The membranes are then submerged in a cleaning fluid and the pressure within the cleaning chamber is reduced causing the cleaning fluid to form bubbles. The process and system of the present disclosure is well suited to cleaning filter membranes, particularly ceramic membranes, in-line without having to remove the membranes from the water purification system.
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公开(公告)号：US10436338B2
公开(公告)日：2019-10-08
申请号：US15836646
申请日：2017-12-08
申请人： LONZA LTD
发明人： Michael Mietzner
摘要： A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. The rupture membrane is positioned within the body such that the rupture membrane does not extend beyond the first end of the body. A process system including the rupture disk is also provided. A method of maintaining a process system that includes the rupture disk is also provided.
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公开(公告)号：US20230183623A1
公开(公告)日：2023-06-15
申请号：US18162774
申请日：2023-02-01
申请人： Lonza Ltd
发明人： Michael Mietzner , Rajesh Beri , Edward Gunderson
CPC分类号： C12M23/02 , C12M27/02 , C12M23/28 , C12M23/14 , C12P21/00 , C12M41/48 , C12M43/00 , C12P21/005
摘要： A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.
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公开(公告)号：US11519515B2
公开(公告)日：2022-12-06
申请号：US16558655
申请日：2019-09-03
申请人： Lonza Ltd
发明人： Michael Mietzner
摘要： A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. The rupture membrane is positioned within the body such that the rupture membrane does not extend beyond the first end of the body. A process system including the rupture disk is also provided. A method of maintaining a process system that includes the rupture disk is also provided.
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