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公开(公告)号：US10562983B2
公开(公告)日：2020-02-18
申请号：US15104561
申请日：2014-12-15
发明人： Sung Hwan Bang , Ju Hee Shin , Jin Ryul Son , Kyung Yeol Park , Jeong Hee Chun , Ji Seon Jeong , Sang Youb Lee
摘要： Disclosed are a method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains and HPMCAS grains. The disclosed method for preparing HPMCAS grains comprises: a step of esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride, and succinic anhydride in a reaction medium in the presence of a catalyst so as to obtain a reaction solution containing HPMCAS (esterification step); and a step of continuously or intermittently putting the reaction solution into water so as to form grains (granulating step).
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公开(公告)号：US10765668B2
公开(公告)日：2020-09-08
申请号：US16464491
申请日：2017-05-10
发明人： Kwang Il Shin , Kyung Yeol Park , Sang Youb Lee
IPC分类号： A61K31/4439 , A61K9/00 , A61K9/28 , A61K9/20
摘要： The present invention relates to: an oral tablet composition comprising amorphous dexlansoprazole, mannitol having an average particle size of 100 to 400 μm, a disintegrating agent and a lubricant; an oral tablet comprising same; and a method for manufacturing same. The oral tablet composition, according to the present invention, exhibits excellent hardness, has a shortened disintegration time, and at the same time, may be used to provide an oral tablet having improved friability. In addition, according to the present invention, a dry direct compression method is used as the method for manufacturing the oral tablet, and thus an increase in production efficiency by simplifying the production process may be achieved.
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3.发明申请公开(公告)号：US20210076721A1
公开(公告)日：2021-03-18
申请号：US16956245
申请日：2018-03-23
发明人： Eun Ji Lim , Sang Youb Lee
IPC分类号： A23L29/262 , A23P10/28 , A23L29/212 , A23L29/30
摘要： Disclosed are a binder composition for bar-shaped solid foods, and a bar-shaped solid food including the binder composition for bar-shaped solid foods. The disclosed binder composition for bar-shaped solid foods includes cellulose ether and saccharides.
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公开(公告)号：US20200155457A1
公开(公告)日：2020-05-21
申请号：US16627662
申请日：2018-06-29
发明人： Kwang Il Shin , Sang Youb Lee
IPC分类号： A61K9/16 , A61K9/20 , A61K9/28 , A61K31/4439
摘要： Provided are an oral solid preparation composition, including a proton pump inhibitor or a pharmaceutically acceptable salt thereof; and a binding liquid including a basic additive, wherein a content of the basic additive is 2 to 13 parts by weight based on 100 parts by weight of the proton pump inhibitor or a pharmaceutically acceptable salt thereof; an oral solid preparation including the same; and a method of preparing the same. According to the present disclosure, an oral solid preparation exhibiting a significant reduction in the production of related substances and excellent stability against moisture and low pH is provided.
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5.发明申请公开(公告)号：US20190275023A1
公开(公告)日：2019-09-12
申请号：US16464491
申请日：2017-05-10
发明人： Kwang Il Shin , Kyung Yeol Park , Sang Youb Lee
IPC分类号： A61K31/4439 , A61K9/28 , A61K9/20
摘要： The present invention relates to: an oral tablet composition comprising amorphous dexlansoprazole, mannitol having an average particle size of 100 to 400 μm, a disintegrating agent and a lubricant; an oral tablet comprising same; and a method for manufacturing same. The oral tablet composition, according to the present invention, exhibits excellent hardness, has a shortened disintegration time, and at the same time, may be used to provide an oral tablet having improved friability. In addition, according to the present invention, a dry direct compression method is used as the method for manufacturing the oral tablet, and thus an increase in production efficiency by simplifying the production process may be achieved.
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