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公开(公告)号：US10562983B2
公开(公告)日：2020-02-18
申请号：US15104561
申请日：2014-12-15
发明人： Sung Hwan Bang , Ju Hee Shin , Jin Ryul Son , Kyung Yeol Park , Jeong Hee Chun , Ji Seon Jeong , Sang Youb Lee
摘要： Disclosed are a method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains and HPMCAS grains. The disclosed method for preparing HPMCAS grains comprises: a step of esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride, and succinic anhydride in a reaction medium in the presence of a catalyst so as to obtain a reaction solution containing HPMCAS (esterification step); and a step of continuously or intermittently putting the reaction solution into water so as to form grains (granulating step).
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2.发明申请AQUEOUS COMPOSITION FOR HARD CAPSULE, AND HARD CAPSULE PRODUCED USING SAME 审中-公开用于硬胶囊的水性组合物和使用其制造的硬胶囊公开(公告)号：US20160317450A1
公开(公告)日：2016-11-03
申请号：US15108860
申请日：2014-07-30
发明人： Jin Ryul Son , Jeong Hee Chun , Ji Seon Jeong
IPC分类号： A61K9/48 , A61K31/155
CPC分类号： A61K9/485 , A61K9/4816 , A61K9/4858 , A61K9/4866 , A61K31/155
摘要： The present invention relates to an aqueous composition for a hard capsule, a method for producing same, and a hard capsule produced using the aqueous composition. More specifically, the present invention relates to an aqueous composition for a hard capsule, the amount of a gelation agent and a gelation auxiliary agent included in the composition having been reduced to appropriate amounts thereby improving the dissolution rate of a hard capsule, and to a hard capsule produced using the aqueous composition.
摘要翻译： 本发明涉及一种硬胶囊用水性组合物及其制造方法以及使用该水性组合物制造的硬胶囊。 更具体地说，本发明涉及用于硬胶囊的水性组合物，包含在组合物中的凝胶化剂和凝胶化助剂的量已经被还原成适当的量，从而提高了硬胶囊的溶解速率， 使用水性组合物制备的硬胶囊。
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3.发明申请AQUEOUS COMPOSITION FOR HARD CAPSULE, AND HARD CAPSULE PRODUCED USING SAME 审中-公开用于硬胶囊的水性组合物和使用其制造的硬胶囊公开(公告)号：US20160317451A1
公开(公告)日：2016-11-03
申请号：US15108874
申请日：2014-07-30
发明人： Jin Ryul Son , Jeong Hee Chun
IPC分类号： A61K9/48 , C09D101/28
CPC分类号： A61K9/4816 , C09D101/284
摘要： The present invention relates to an aqueous composition for a hard capsule, a method for producing same, and a hard capsule produced using the aqueous composition. More specifically, the present invention relates to an aqueous composition for a hard capsule which comprises a small amount of alcohol and thus has guaranteed stability and excellent capsule moldability, and to a hard capsule produced using the aqueous composition.
摘要翻译： 本发明涉及一种硬胶囊用水性组合物及其制造方法以及使用该水性组合物制造的硬胶囊。 更具体地说，本发明涉及一种含有少量醇的硬胶囊用水性组合物，由此具有保证稳定性和优异的胶囊成型性，以及使用该水性组合物制造的硬胶囊。
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4.发明申请AQUEOUS COMPOSITION FOR HARD CAPSULE, AND HARD CAPSULE PRODUCED USING SAME 审中-公开用于硬胶囊的水性组合物和使用其制造的硬胶囊公开(公告)号：US20160324790A1
公开(公告)日：2016-11-10
申请号：US15108847
申请日：2014-07-30
发明人： Jin Ryul Son , Jeong Hee Chun
CPC分类号： A61K9/4816 , C08L1/284
摘要： The present invention relates to an aqueous composition for a hard capsule, the composition having an improved degree of gelation, and to a hard capsule produced using the aqueous composition. The present invention enables the production of an aqueous composition for a hard capsule, the composition having an excellent degree of gelation due to comprising a gelation agent and a gelation auxiliary agent along with water-soluble cellulose ether, alcohol and water, and as a result a high quality hard capsule having improved hard capsule moldability can be produced. Furthermore, the alcohol improves the solubility of the water-soluble cellulose ether, and thus a stable gel power can be maintained by only a small amount of gelation agent, thereby resolving the problem of the gelation agent causing a drop in solubility time.
摘要翻译： 本发明涉及用于硬胶囊的水性组合物，该组合物具有改善的凝胶化程度，以及使用该水性组合物制备的硬胶囊。 本发明能够制备用于硬胶囊的水性组合物，该组合物由于包含凝胶剂和凝胶化助剂以及水溶性纤维素醚，醇和水而具有优异的凝胶化程度，结果 可以制造具有改进的硬胶囊成型性的高品质硬胶囊。 此外，醇改善了水溶性纤维素醚的溶解性，因此仅通过少量的凝胶剂可以维持稳定的凝胶力，从而解决了凝胶化剂引起溶解时间下降的问题。
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