公开(公告)号：US20240050571A1

公开(公告)日：2024-02-15

申请号：US18175956

申请日：2023-02-28

Applicant: LOYOLA UNIVERSITY OF CHICAGO

Inventor： Daniel Paul Becker ,  Marlon Ray Lutz, JR.

IPC: A61K41/00 ,  A61K47/54 ,  C07F7/08

CPC classification number: A61K41/0095 ,  A61K47/545 ,  C07F7/0814

Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: Formula (I) wherein the substituents are as described.